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Fernando Danilo González Nilo

Principal Investigator of Centro Interdisciplinario de Neurociencias de Valparaíso.
Principal Investigator of PMI UNAB for Bionanotechnology.
Principal Investigator of Fraunhofer Chile Research Fundation.
Professor (Senior Lecturer), Director of the Center for Bioinformatics and Integrative Biology.
Director of the School of Bioinformatics Engineering.
Chemistry PhD. (2000) Facultad de Química y Biología. Universidad de Santiago de Chile (USACH)

Curriculum Vitae

Contact information:

Phone: +56-2-770 3405
Postal Code: 8370146
Address: Center for Bioinformatics and Integrative Biology (CBIB)
Facultad de Ciencias Biológicas
Universidad Andres Bello
Av, Republica 217, Santiago, Chile

Dr. Fernando Danilo González Nilo, Ph.D. in Chemistry (43), is a full professor and Director of the Center for Bioinformatics and Integrative Biology (CBIB), at Universidad Andres Bello. The CBIB of the University Andres Bello houses a trans-disciplinary team whose main goal is to develop research strategies that bring together the benefits of computational and experimental validation methods. The CBIB highly integrated approach favors an iterative research cycle based on observation, modeling, simulation, and validation. This approach is supported by a high performance computing system (SGI ICE 8400 with 1.536 cores and 3TB of RAM memory), enabling the development and use of high-performance molecular simulation and bioinformatics tools in areas as diverse as Molecular Design, Protein Engineering, and Omics-Technologies. The computer system is tightly integrated to the Protein Engineering, Cell biology and Electron Microscopy laboratories. This arrangement in central to CBIB design for the development of multidisciplinary initiatives that allow exploring new questions in integrative biology.

CBIB team take part in multiple theoretical-experimental projects through collaborative efforts with national and international groups specialized in biophysics, enzymatic catalysis, computer based drug design, transmembrane proteins and bio- and nano-technology, among others. In the field of nanobiology, CBIB maintains a tight collaboration with the National Cancer Institute (NCI, USA) for the adaptation and development bioinformatics tools for nanoparticle characterization with the main objective to apply nanotechnology in medicine and biological systems. Other line that my group is focused, within the CBIB, in the development and implementation of advanced methods in Molecular Dynamics simulations for the analysis and characterization of the structural determinants that govern the activation and conductance of K channels (SHAKER, HSlo, TRPV1 and TRPM8).

  • Rodrigo Vasquez-Del Carpio, Fernando D. González-Nilo, Hariharan Jayaram, Eugenio Spencer, B. V. Venkataram Prasad, John T. Patton and Zenobia F. Taraporewala. (2004) Role of the HIT-Like Motif in Nucleotide Hydrolysis by the Rotavirus RNAPackaging Protein NSP2.  J. Biol. Chem., Vol. 279(11), 10624-10633, 2004. Cover Figure
  • María Isabel Niemeyer, Fernando D. González-Nilo, Leandro Zúñiga, Wendy González, L. Pablo Cid & Francisco V. Sepúlveda. (2007) Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel.  Proceeding of the National Academy of Sciences,  104 (2): 666-671.
  • Brauchi S., Orta G., Mascayano C., Salazar M., Raddatz N., Urbina H., Rossenmann E., Gonzalez-Nilo F., Latorre R (2007) Dissection of the Components for PIP2 activation and Thermosensation in TRP Channels. . Proceeding of the National Academy of Sciences,  104(24):10246-10251.
  • Carvacho I, Gonzalez W, Torres YP, Brauchi S, Alvarez O, Gonzalez-Nilo FDLatorre R (2008) Intrinsic electrostatic potential in the BK channel pore: role in determining single channel conductance and block. . J. Gen. Physiol. Feb;131(2):147-61. Figure Cover
  • Fernando Gonzalez-Nilo, Tomas Perez-Acle, Sergio Guinez-Molinos, Daniela Geraldo, Claudia Sandoval, Alejandro Yevenes, Leonardo S. Santos, V. Felipe Laurie, Hegaly Mendoza And Raul E. Cachau. (2011) Nanoinformatics: an emerging area of information technology at the intersection of bioinformatics, computational chemistry and nanobiotechnology.  Biological Research.  Accepted. Review
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