Tomás Pérez-Acle

Associated Researcher – Professor at Centro Interdisciplinario de Neurociencias de Valparaíso (CINV), Universidad de Valparaíso, Valparaíso.
Head Researcher at Computational Biology Lab (DLab), Fundación Ciencia & Vida, Santiago, Chile.
Executive Director at National Laboratory for High Performance Computing (NLHPC), Center for Mathematical Modeling, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile.
Biologist, Faculty of Natural Sciences, Universidad de Concepción, Chile.
Master of Sciences in Biomedical Physics, Faculty of Medicine and Faculty of Sciences, Universidad de Chile.
Ph. D. in Biotechnology, Faculty of Biological Sciences, Universidad Andrés Bello, Chile.

Curriculum Vitae

Contact information:

E-mail: tomas@dlab.cl
Pasaje Harrington 287, Playa Ancha. Valparaíso
Teléfono: (56)-(32)-2508040

The main objective of DLab is to produce multiscale computational models to explain complex biological phenomena. To do so, we use tools coming from mathematical modeling and high performance computing (HPC). At the microscale (atomic), we use molecular modeling and molecular simulations to understand the fundamental properties that govern biological processes such as intercellular communication, membrane transport and molecular recognition. At the meso and macroscale, we use rule-based modeling and network topology to produce  and characterize stochastic simulations of cell signaling, gene regulation and infectious diseases.

  • González A, Perez-Acle T, Pardo L, Deupi X. (2011) Molecular basis of ligand dissociation in B-adrenergic receptors.
  • González-Nilo F, Pérez-Acle T, Guínez-Molinos S, Geraldo DA, Sandoval C, Yévenes A, Santos LS, Laurie VF, Mendoza H, Cachau RE. (2011) Nanoinformatics: an emerging area of information technology at the intersection of bioinformatics, computational chemistry and nanobiotechnology.
  • Lizama C, Lagos CF, Lagos-Cabré R, Cantuarias L, Rivera F, Huenchuñir P, Pérez-Acle T, Carrión F, Moreno RD. (2009) Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes.
  • Gonzalez A, Duran LS, Araya-Secchi R, Garate JA, Pessoa-Mahana CD, Lagos CF, Perez-Acle T. Computational modeling study of functional microdomains in cannabinoid receptor type 1. Bioorg Med Chem. 2008 Apr 15;16(8):4378-89. Epub 2008 Feb 26.
  • Hantavirus Gc glycoprotein: evidence for a class II fusion protein. (2005)  Tischler ND, Gonzalez A, Perez-Acle T, Rosemblatt M, Valenzuela PD. J Gen Virol. 2005 Nov;86(Pt 11):2937-47.
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