Carlos González
Estructura y función de sensores moleculares

Full Professor Universidad de Valparaíso
Adjunct Professor of Texas Tech University, Texas, USA
Bsc & MSc in Biophysics: State University of Moscow, Russia
PhD in Mol. and Cell Biology & Neur. (in Biophysics), Universidad de Chile
Postdoctoral fellows: NIH, University of Virginia & University of Miami
Researcher: Centro Interdisciplinario de Neurociencia de Valparaíso
Editor Board Member of JBC
Deputy Director of Biophysics and Computational Biology PhD Program at University of Valparaíso

Research Statement:

Our research aims to understand the molecular mechanisms underlying the way that different ion channels operate, using the combination of molecular biology, classic electrophysiology, fluorometry, kinetic modeling, molecular modeling, quantum mechanics and mathematical modeling, and  their association with some disseases like cancer, asthma and deafness.

Research Lines:

  1. Ion channel biophysics
  2. Channelopathies (Cancer, deafness, asthma)
  3. Physiology (Secretion)
  4. Computational modeling (Molecular modeling, kinetic modeling, molecular dynamics and quantum mechanics)
  5. Mathematical modeling (associated to the ion channel behaviour)

Selected publications:

  • Qiu F, et al (2016) Molecular mechanism of Zn2+ inhibition of a voltage-gated proton channel. PNAS. USA. 113(40):E5962-E5971. IF: 9,423
  • Latorre R, et al (2016). Molecular determinants of BK channel functional diversity and functioning. Physiol Rev, 97(1):39-87. Review. IF: 30,924
  • Diaz-Franulic I, et al (2016) Allosterism and Structure in Thermally Activated Transient Receptor Potential Channels Ann. Rev. Biophys. Jul 5;45:371-98 IF: 11,325
  • Castillo K, et al (2015) Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels..  PNAS USA. 112(15):4809-14 IF: 9,423
  • Pupo A & Gonzalez C. In pursuit of an inhibitory drug for the proton channel (Hv1). (2014) PNAS. USA. 11:27, 9673-74. IF: 9,423

Curriculum Vitae

Contact information:

E-mail: carlos.gonzalezl at uv.cl
Phone: (56)-(32)-299 5522
Fax: (56)-(32)-250 8047
Address: Centro Interdisciplinario de Neurociencia de Valparaíso.
Facultad de Ciencias, Universidad de Valparaíso.
Pasaje Harrington 269, Playa Ancha, Valparaíso. Chile.

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