Evandro Ferrada
Profesor Adjunto, Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valparaíso, Chile.
Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Universidad de Valparaíso, Chile.
Instituto de Sistemas Complejos de Valparaíso (ISCV), Valparaíso, Chile.
PhD in Biology, University of Zurich, Zurich, Switzerland.
BSc in Biochemistry, Pontificia Universidad Católica de Chile, Santiago, Chile.
Contact information:
E-mail: evandro.ferrada@uv.cl
Pasaje Harrington 269 Playa Ancha. Valparaíso, Chile.
Phone: (56)-(32)-2508040
In my research, I investigate how evolutionary forces —ranging from cellular processes to the ecology and lifestyles of organisms— impact the evolution of genes, genomes, and phenotypes. My primary questions focus on the forces that shape the evolution of macromolecular structures, functions, and interactions at a genome-wide level, as well as their consequences for organismal adaptation. To explore these questions, I employ techniques from bioinformatics and computational biology, quantitative descriptions of the evolutionary process, statistical analysis of empirical data, computer simulations, and mathematical modeling.
- Ferrada, E. ”Quantifying the mutational robustness of protein-coding genes from large-scale mutagenesis data”. Journal of Molecular Evolution, 89, 357-369 (2021).
- Ferrada, E. ”The site-specific amino acid preferences of homologous proteins depend on sequence divergence” Genome biology and evolution, 11(1), 121-135 (2019).
- Ferrada, E. ”The amino acid alphabet and the architecture of the protein sequence-structure map. I. Binary alphabets.” PLoS Computational Biology , 10.12: e1003946, (2014).
- Ferrada, E. and Wagner, A. ”A comparison of the genotype-phenotype maps for RNA and proteins”. Biophysical J. 102:1916-1925, (2012).
- Ferrada, E. and Wagner, A. ”Protein robustness promotes evolutionary innovations on large evolutionary time scales”. Proc. R. Soc. B 275(1643):1595-1602, (2008).
