and The Molecular Basis of Excitability
![]() Interactive solution of the Hodgkin-Huxley equations: voltage clamp, membrane action potential, propagated action potential. Includes circuit with all the currents in the cable model of the axon during propagation. User can change stimulus parameters,ion concentrations, maximum conductances, temperature, add blockers and display all the variables such as conductance or currents. NEW: myelinated nerve. |
![]() The circuit of a patch of membrane with capacitance, conductances and equilibrium potentials showing currents. 1.Conductances can be interactive. 2. Simulation of passive membrane under current clamp showing currents. 3. Simulation of active membrane showing currents and conductances (membrane action potential). |
![]() A voltage-gate potassium channel. Basic structure that gives origin to the function. Stochastic simulation of single channel gating currents and single channel ionic currents and the ensemble average of macroscopic gating and ionic currents. User can modify the voltage pattern . |
![]() An eukaryotic voltage dependent Sodium channel. Basic structure indicating how different domains give origin to the function of the channel. Stochastic simulation of single gating and ionic currents including activation and inactivation and how the macroscopic current is build up from the ensemble average of the single events. User can modify the voltage pattern. |
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This program shows the squid giant axon passive properties and
how a current stimulus generate a distribution of membrane potential
along the axon. The concepts of time constant and space constant are
presented. The user can modify the electrical parameters of the axon and
observe the results in the voltage and currents as a function of distance
and time. |
>![]() Program computes I-V curves for single ionic species as well as a membrane containing Na, K and Cl selective ion pathways.User can change ion valence for the single ion species, internal and external ionic concentrations, temperature, as well as permeabilties for the multiple pathway case. The output is the I-V plot and the reversal potential. |
Contact me for comments or questions: fbezanilla@uchicago.edu or Francisco.Bezanilla@uv.cl
Thank you for using these programs.
F. Bezanilla
(C) F. Bezanilla, 1998- 2024. Last updated 5/24