1. Acarón Ledesma H, Li X, Carvalho-de-Souza JL, Wei W, Bezanilla F, Tian B (2019) An atlas of nano-enabled neural interfaces. Nat Nanotechnol. 14(7):645-657. doi: 10.1038/s41565-019-0487-x
  2. Alvarez O, Castillo K, Carmona E, Gonzalez C y Latorre R. (2019) Methods for Investigating TRP Channel Gating. In: Ferrer-Montiel A., Hucho T. (eds) TRP Channels. Methods in Molecular Biology, vol 1987. Humana, New York, NY
  3. Asencio-Barría C, Defamie N, Sáez JC, Mesnil M, Godoy AS. (2019) Direct Intercellular Communications and Cancer: A Snapshot of the Biological Roles of Connexins in Prostate Cancer. Cancers (Basel). 11(9). pii: E1370. doi: 10.3390/cancers11091370
  4. Bernardi M, Marracino P, Liberti M, Gárate JA, Burnham CJ, Apollonio F, English NJ (2019) Controlling ionic conductivity through transprotein electropores in human aquaporin 4: a non-equilibrium molecular-dynamics study. Phys Chem Chem Phys. 21(6):3339-3346. doi: 10.1039/c8cp06643d
  5. Caneo M, Julian V, Byrne AB, Alkema MJ, Calixto A. (2019) Diapause induces functional axonal regeneration after necrotic insult in C. elegans. PLoS Genet. 15(1):e1007863. doi: 10.1371/journal.pgen.1007863
  6. Carvalho-de-Souza JL, Bezanilla F. (2019) Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker. Nat Commun. 10(1):3584. doi: 10.1038/s41467-019-11545-7.
  7. Cavieres A, Campos-Estrada C, Moya Y, Maldonado R, González-Vargas R, Bustamante ML, Moya PR. (2019) Lack Of Association Between The IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, And Treatment Resistance In Chilean Schizophrenic Patients Treated With Clozapine. Schizophr Res Treatment. 2019:5601249. Doi: 10.1155/2019/5601249
  8. Cea LA, Balboa E, Vargas AA, Puebla C, Brañes MC, Escamilla R, Regueira T, Sáez JC. (2019) De novo expression of functional connexins 43 and 45 hemichannels increases sarcolemmal permeability of skeletal myofibers during endotoxemia. Biochim Biophys Acta Mol Basis Dis. 1865(10):2765-2773. doi: 10.1016/j.bbadis.2019.06.014
  9. Chávez FP, Calixto A. (2019) Use Of C. Elegans Diapause To Study Transgenerational Responses To Pathogen Infection. In: Bridier A. (eds) Foodborne Bacterial Pathogens: Methods And Protocols, Methods In Molecular Biology, Vol 1918. 191-197. Humana Press, New York, NY. Doi: 10.1007/978-1-4939-9000-9_16.
  10. Chiu CQ, Barberis A, Higley MJ. (2019) Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity. Nat Rev Neurosci. 20(5):272-281. doi: 10.1038/s41583-019-0141-5
  11. Delgado, S.E., González-Arancibia, C. (2019) ”Polizones aéreos: vida microbiana sobre, bajo y atráves de las olas” Anales del Museo de Historia Natural de Valparaíso vol. 31
  12. Duarte Y, Márquez-Miranda V, Miossec MJ, Gonzalez-Nilo F (2019) Integration of target discovery, drug discovery and drug delivery: A review on computational strategies. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 11(4):e1554. doi: 10.1002/wnan.1554
  13. Escobar MJ, Alexandre F, Viéville T, Palacios AG. (2019). Rapid Prototyping for Bio–Inspired Robots. In Rapid Roboting: Recent Advances on 3D Printers and Robotics, Intelligent Systems, Control and Automation: Science and Engineering. Auat FA,Prieto PA, Fantoni G. editors. Springer International Publishing. Chapter 1. 82: 1-34.
  14. Eugenin EA, Valdebenito S, Gorska AM, Martínez AD, Bitran M, Sáez JC (2019) Gap junctions coordinate the propagation of glycogenolysis induced by norepinephrine in the pineal gland. J Neurochem. 2019 Aug 5. doi: 10.1111/jnc.14846. [Epub ahead of print]
  15. Gárate JA, Bernardin A, Escalona Y, Yanez C, English NJ, Pérez-Acle T. (2019) Orientational and Folding Thermodynamics via Electric Dipole Moment Restraining. J Phys Chem B. 123(12):2599-2608 doi: 10.1021/acs.jpcb.8b09374.
  16. Gómez GI, Velarde V, Sáez JC. (2019) Role of a RhoA/ROCK-Dependent Pathway on Renal Connexin43 Regulation in the Angiotensin II-Induced Renal Damage. Int J Mol Sci. 20(18). pii: E4408. doi: 10.3390/ijms20184408.
  17. Granados ST, Castillo K, Bravo-Moraga F, Sepúlveda RV, Carrasquel-Ursulaez W, Rojas M, Carmona E, Lorenzo-Ceballos Y, Gonzalez-Nilo F, Gonzalez C, Latorre R, Torres YP (2019) The molecular nature of the 17β-Estradiol binding site in the voltage- and Ca2+-activated K+ (BK) channel β1 subunit. Scientific Reports. 9(1): 9965 doi: 10.1038/s41598-019-45942-1
  18. Guerra MJ, González-Jamett AM, Báez-Matus X, Navarro-Quezada N, Martínez ADNeely ACárdenas AM. (2019) The Ca2+ channel subunit CaV β2a down-regulates voltage-activated ion current densities by disrupting actin-dependent traffic in chromaffin cells. J Neurochem. 2019 Aug 16. doi: 10.1111/jnc.14851. [Epub ahead of print]
  19. Holder MJ, Wright HJ, Couve E, Milward MR, Cooper PR. (2019) Neutrophil Extracellular Traps Exert Potential Cytotoxic and Proinflammatory Effects in the Dental Pulp. J Endod. 45(5):513-520. doi: 10.1016/j.joen.2019.02.014.
  20. Jiang Y, Parameswaran R, Li X, Carvalho-de-Souza JL, Gao X, Meng L, Bezanilla F, Shepherd GMG, Tian B (2019) Nongenetic optical neuromodulation with silicon-based materials. Nat Protoc. 14(5):1339-1376. doi: 10.1038/s41596-019-0135-9
  21. Lee EEL, Bezanilla F . (2019) Methodological improvements for fluorescence recordings in Xenopus laevis oocytes. J Gen Physiol. 151(2):264-272. doi: 10.1085/jgp.20181218
  22. Legue M and Calixto A. (2019) RNA language in Caenorhabditis elegans and bacteria interspecies communication and memory. Current Opinion in Systems Biology. 13: 16-22
  23. Lima TI, Guimarães DSPSF, Oliveira AG, Araujo H, Sponton CHG, Souza-Pinto NC, Saito Â, Figueira ACM, Palameta S, Bajgelman MC, Calixto A, Pinto S, Mori MA, Orofino J, Perissi V, Mottis A, Auwerx J, Silveira LR. (2019) Opposing action of NCoR1 and PGC-1α in mitochondrial redox homeostasis. Free Radic Biol Med. 143:203-208. doi: 10.1016/j.freeradbiomed.2019.08.006.
  24. Lorenzo-Ceballos Y, Carrasquel-Ursulaez W, Castillo K, Alvarez O, Latorre R. (2019) Calcium-driven regulation of voltage-sensing domains in BK channels. Elife. 8. pii: e44934. doi: 10.7554/eLife.44934.
  25. Manríquez R, Peterson SD, Prado P, Orio P, Galindo GE, Zañartu M (2019) Neurophysiological Muscle Activation Scheme for Controlling Vocal Fold Models. IEEE Trans Neural Syst Rehabil Eng. 27(5):1043-1052. doi: 10.1109/TNSRE.2019.2906030
  26. Olivares J and Schmachtenberg O (2019) An update on anatomy and function of the teleost olfactory system. PeerJ, 7:e7808 doi: 10.7717/peerj.7808
  27. Osorio MI, Cabrera MA, Gonzalez-Nilo F, Pérez-Donoso JM. (2019) Odd Loop Regions of XenA and XenB Enzymes Modulate Their Interaction with Nitro-explosives Compounds and Provide Structural Support for Their Regioselectivity. J Chem Inf Model. 59(9):3860-3870. doi: 10.1021/acs.jcim.9b00357
  28. Pérez MÁ, Morales C, Santander O, García F, Gómez I, Peñaloza-Sancho V, Fuentealba P, Dagnino-Subiabre A, Moya PR., Fuenzalida M. (2019) Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats. Front Cell Neurosci. 13:372. doi: 10.3389/fncel.2019.00372
  29. Pinto C, Medinas DB, Fuentes-Villalobos F, Maripillán J, Castro AF, Martínez AD, Osses N, Hetz C, Henríquez JP. (2019) β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation. Neurobiol Dis. 130:104497. doi: 10.1016/j.nbd.2019.104497
  30. Piña R, Ugarte G, Campos M, Íñigo-Portugués A, Olivares E, Orio P,, Belmonte C, Bacigalupo J, Madrid R. (2019) Role of TRPM8 channels in altered cold sensitivity of corneal primary sensory neurons induced by axonal damage. J Neurosci. 239(41):8177-8192. doi: 10.1523/JNEUROSCI.0654-19.2019
  31. Poch A, Villanelo F, Henriquez S, Kohen P, Muñoz A, Strauss JF 3rd, Devoto L. (2019) Molecular modelling predicts that 2-methoxyestradiol disrupts HIF function by binding to the PAS-B domain. Steroids. 144:21-29. doi: 10.1016/j.steroids.2019.02.004.
  32. Ravello CR, Perrinet LU , Escobar MJ , Palacios AG (2018) Speed-Selectivity in Retinal Ganglion Cells is Sharpened by Broad Spatial Frequency, Naturalistic Stimuli. Scientific Report. 9(1):456. doi: 10.1038/s41598-018-36861-8
  33. Scala R, Maqoud F, Angelelli M, Latorre R, Perrone MG, Scilimati A, Tricarico D. (2019)  Zoledronic Acid Modulation of TRPV1 Channel Currents in Osteoblast Cell Line and Native Rat and Mouse Bone Marrow-Derived Osteoblasts: Cell Proliferation and Mineralization Effect. Cancers (Basel). 11(2). pii: E206. doi: 10.3390/cancers11020206.
  34. Whitlock KE, Postlethwait J, Ewer J. (2019) Neuroendocrinology of reproduction: Is Gonadotropin-Releasing Hormone (GnRH) dispensable? Front Neuroendocrinol. 53:100738 doi: 10.1016/j.yfrne.2019.02.002. Review


  1. Acevedo W, Capitaine C, Rodríguez R, Araya‐Durán I, Gonzalez-Nilo F, Pérez‐Correa JR, Agosin E (2018) Selecting optimal mixtures of natural sweeteners for carbonated soft drinks through multi‐objective decision modeling and sensory validation. Journal of Sensory Studies. 33(6): e12466. doi: 10.1111/joss.12466
  2. Alvarez O, Carmona E, Latorre R & Gonzalez C. (2018) A Glimpse into the Permeation Pathway of the Voltage-Dependent Proton Channel (Hv1). Comments on CrossTalk 33: Proton permeation through HV1 requires/does not require transient protonation of a conserved aspartate in the S1 transmembrane helix. Journal of Physiology. doi: 10.1113/JP275101
  3. Balboa E, Saavedra F, Cea LA, Vargas AA, Ramírez V, Escamilla R, Sáez JC, Regueira T. (2018) Sepsis-Induced Channelopathy in Skeletal Muscles is Associated with Expression of Non-Selective Channels. Shock. 49(2):221-228. doi: 10.1097/SHK.0000000000000916
  4. Barría I, Güiza J, Cifuentes F, Zamorano P, Sáez JC, González J, Vega JL. (2018) Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes. Am J Trop Med Hyg. 1860(1):91-95. doi: 10.1016/j.bbamem.2017.10.006
  5. Bernardi M, Marracino P, Ghaani MR, Liberti M, Del Signore F, Burnham CJ, Gárate JA, Apollonio F, English NJ. (2018) Human aquaporin 4 gating dynamics under axially oriented electric-field impulses: A non-equilibrium molecular-dynamics study. J Chem Phys. 149(24):245102. doi: 10.1063/1.5044665.
  6. Bezanilla F (2018) Influences: The Cell Physiology Laboratory in Montemar, Chile. J Gen Physiol. 150(11):1464-1468. doi: 10.1085/jgp.201812157.
  7. Bonansco C, Martínez-Pinto J, Silva RA, Velásquez VB, Martorell A, Selva MV, Espinosa P, Moya PR, Cruz G, Andrés ME, Sotomayor-Zárate R. (2018) Neonatal exposure to estradiol increases dopaminergic transmission in Nucleus Accumbens and morphine-induced conditioned place preference in adult female rats. J Neuroendocrinol. 230(7):e12574. Doi: 10.1111/jne.1257
  8. Borio A, Holgado A, Garate JA, Beyaert R, Heine H, Zamyatina A. (2018) Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation. ChemMedChem. 13(21):2317-2331 doi: 10.1002/cmdc.201800505.
  9. Bustos Á, Fuenzalida I, Santibáñez R, Pérez-Acle T, Martin AJM. (2018) Rule-Based Models and Applications in Biology. Chapter in: Computational Cell Biology: Methods and Protocols, Methods in Molecular Biology, Louise von Stechow and Alberto Santos Delgado (eds.), Methods Mol Biol. 1819:3-32. doi: 10.1007/978-1-4939-8618-7_1
  10. Camarada MB, Comer J, Poblete H, Azhagiya Singam ER, Marquez-Miranda V, Morales-Verdejo C, Gonzalez-Nilo FD (2018) Experimental and Computational Characterization of the Interaction between Gold Nanoparticles and Polyamidoamine Dendrimers. Langmuir. 34(34):10063-10072. doi: 10.1021/acs.langmuir.8b01809
  11. Carmona EM, Larsson HP, Neely A, Alvarez O, Latorre R, Gonzalez C. (2018) Gating charge displacement in a monomeric voltage-gated proton (Hv1) channel.  Proc Natl Acad Sci USA. 115(37):9240-9245. doi: 10.1073/pnas.1809705115
  12. Carrasquel-Ursulaez W, Alvarez O, Bezanilla F, Latorre R (2018) Determination of the Stoichiometry between α- and γ1 Subunits of the BK Channel Using LRET. Biophys J. 114(11):2493-2497. doi: 10.1016/j.bpj.2018.04.008
  13. Carrasquel-Ursulaez W, Lorenzo Y, Echeverria F and Latorre R 2018. Large conductance potassium channels in the nervous system.  In: The Oxford Handbook of Neuronal Ion Channels, Oxford Handbooks Online, UK. Online publication date: April 2018. DOI: 10.1093/oxfordhb/9780190669164.013.11.
  14. Carvalho-de-Souza JL, Pinto BI, Pepperberg DR, Bezanilla F. (2018) Optocapacitive Generation of Action Potentials by Microsecond Laser Pulses of Nanojoule Energy. Biophys J. 114(2):283-288. doi: 10.1016/j.bpj.2017.11.018
  15. Chiu CQ, Martenson JS, Yamazaki M, Natsume R, Sakimura K, Tomita S, Tavalin SJ, Higley MJ. (2018) Input-Specific NMDAR-Dependent Potentiation of Dendritic GABAergic Inhibition. Neuron. 97(2):368-377.e3. doi: 10.1016/j.neuron.2017.12.032.
  16. Contreras-Riquelme S, Garate JA, Pérez-Acle T, Martin AJM. (2018) RIP-MD: a tool to study residue interaction networks in protein molecular dynamics. PeerJ. 6:e5998. doi: 10.7717/peerj.5998.
  17. Couve E and Schmachtenberg O (2018) Schwann Cell Responses and Plasticity in Different Dental Pulp Scenarios. Front Cell Neurosci. 12:299. doi: 10.3389/fncel.2018.00299
  18. Díaz-Franulic I, González-Pérez V, Moldenhauer H, Navarro-Quezada N, Naranjo D. (2018) Gating-induced large aqueous volumetric remodeling and aspartate tolerance in the voltage sensor domain of Shaker K+ channels. Proc Natl Acad Sci U S A. 115(32):8203-8208. doi: 10.1073/pnas.1806578115
  19. Delgado-Acevedo C, Estay SF, Radke A, Sengupta A, Escobar AP, Henríquez-Belmar F, Reyes C, Haro V, Utreras E, Sotomayor-Zárate R, Cho A, Wendland JR, Kulkarni AB, Holmes A, Murphy DL, Chávez AE, Moya PR (2018) Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression. Neuropsychopharmacology. 44(6):1163-1173. doi: 10.1038/s41386-018-0302-7
  20. Elgueta C, Leroy F, Vielma AH, Schmachtenberg O, Palacios AG (2018) Electrical coupling between A17 cells enhances reciprocal inhibitory feedback to rod bipolar cells. Sci Rep. 8(1):3123. doi: 10.1038/s41598-018-21119-0
  21. Elizondo-García ME, Márquez-Miranda V, Araya-Durán I, Valencia-Gallegos JA, González-Nilo FD (2018) Self-Assembly Behavior Of Amphiphilic Janus Dendrimers In Water: A Combined Experimental And Coarse-Grained Molecular Dynamics Simulation Approach.Molecules. 23(4). Pii: E969. doi: 10.3390/molecules23040969
  22. Escobar MJ, Reyes C, Herzog R, Araya J, Otero M, Ibaceta C, Palacios AG (2018) Characterization of Retinal Functionality at different Eccentricities in a Diurnal Rodent. Front Cell Neurosci (12) 444. Doi:10.3389/fncel.2018.00444
  23. Gajardo I, Salazar CS, Lopez-Espíndola D, Estay C, Flores-Muñoz C, Elgueta C, Gonzalez-Jamett AM, Martínez AD, Muñoz P, Ardiles ÁO (2018) Lack of Pannexin 1 Alters Synaptic GluN2 Subunit Composition and Spatial Reversal Learning in Mice. Front Mol Neurosci. 11:114. doi: 10.3389/fnmol.2018.00114.
  24. García IE, Sánchez HA, Martínez AD, Retamal MA. (2018) Redox-mediated regulation of connexin proteins; focus on nitric oxide. Biochim Biophys Acta. 1860(1):91-95. doi: 10.1016/j.bbamem.2017.10.006
  25. García IE, Villanelo F, Contreras GF, Pupo A, Pinto BI, Contreras JE, Pérez-Acle T, Alvarez OLatorre R, Martínez AD, González C. (2018) The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels. J Gen Physiol. 150(5):697-711. doi: 10.1085/jgp.201711782
  26. Gómez GI, Fernández P, Velarde V, Sáez JC (20218) Angiotensin II-Induced Mesangial Cell Damaged Is Preceded by Cell Membrane Permeabilization Due to Upregulation of Non-Selective Channels. Int J Mol Sci.  19(4). pii: E957. doi: 10.3390/ijms19040957
  27. González-Jamett AM, Bevilacqua JA and Cárdenas AM (2018) “Hereditary Myopathies”. In Muscle Cell and Tissue. Edited by Kunihiro Sakuma; Ed. InTechOpen, Chapter 6, pages 81-114. DOI: 10.5772/intechopen.76076
  28. Guerrero-Beltran C, Rodriguez-Izquierdo I, Serramia MJ, Araya-Durán I, Márquez-Miranda V, Gomez R, de la Mata FJ, Leal M, González-Nilo F, Muñoz-Fernández MA (2018) Anionic Carbosilane Dendrimers Destabilize the GP120-CD4 Complex Blocking HIV-1 Entry and Cell to Cell Fusion. Bioconjug Chem. 29(5):1584-1594. Doi: 10.1021/acs.bioconjchem.8b00106
  29. Güiza J, Barría I, Sáez JC, Vega JL. (2018) Innexins: Expression, Regulation, and Functions. Front Physiol. 9:1414. doi: 10.3389/fphys.2018.01414.
  30. Horng TL, Eisenberg RS, Liu C, Bezanilla F. (2018) Continuum Gating Current Models Computed with Consistent Interactions. Biophys J. 116(2):270-282. doi: 10.1016/j.bpj.2018.11.3140
  31. Juritz EI, Bascur JP, Almonacid DE, González-Nilo FD. (2018) Novel Insights for Inhibiting Mutant Heterodimer IDH1wt-R132H in Cancer: An In-Silico Approach. Mol Diagn Ther. 22(3):369-380. Doi: 10.1007/s40291-018-0331-2
  32. Latorre R, Castillo K, and Díaz-Franulic I (2018) Sensing Pain and Temperature. In: The Proceedings of the Workshop on Cell Biology and Genetics. Edward M. De Robertis (editor). Libreria Editrice Vaticana. Vatican City. Chapter. pag 44-63
  33. López-Jury L, Meza RC, Brown MTC, Henny P, Canavier CC. (2018) Morphological and biophysical determinants of the intracellular and extracellular waveforms in nigral dopaminergic neurons: A computational study. J Neurosci. 38(38):8295-8310. doi: 10.1523/JNEUROSCI.0651-18.201
  34. Marengo FD, Cárdenas AM. (2018) How does the stimulus define exocytosis in adrenal chromaffin cells? Pflugers Arch.470(1):155-167. doi: 10.1007/s00424-017-2052-5
  35. Marracino P, Bernardi M, Liberti M, Del Signore F, Trapani E, Gárate JA, Burnham CJ, Apollonio F, English NJ. (2018) Transprotein-Electropore Characterization: A Molecular Dynamics Investigation on Human AQP4. ACS Omega. 3(11):15361-15369. doi: 10.1021/acsomega.8b02230.
  36. Mathur C, Johnson KR, Tong BA, Miranda P, Srikumar D, Basilio D, Latorre R, Bezanilla F, Holmgren M. (2018) Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation. Sci Rep. 8(1):2207. doi: 10.1038/s41598-018-20684-8
  37. Miramontes-Sequeiros LC, Palanca-Castán N, Caamaño-Chinchilla L, Palanca-Soler A. (2018) The phenotypic variability in Rana temporaria decreases in response to drying habitats. Sci Total Environ. 612:538-543. doi: 10.1016/j.scitotenv.2017.08.261
  38. Moreno M, Zacarias A, Porzel A, Velasquez L, Gonzalez G, Alegría-Arcos M, Gonzalez-Nilo F, Gross EKU (2018) IR and NMR spectroscopic correlation of enterobactin by DFT. Spectrochim Acta A Mol Biomol Spectrosc. 198:264-277. doi: 10.1016/j.saa.2018.02.060.
  39. Moreno M, Zacarias A, Velasquez L, Gonzalez G, Alegría-Arcos M, Gonzalez-Nilo F, Gross EKU. (2018) Experimental and theoretical structural/spectroscopical correlation of enterobactin and catecholamide Data Brief. 20:2054-2064. doi: 10.1016/j.dib.2018.08.114.
  40. Núñez-Vivanco G, Fierro A, Moya P, Iturriaga-Vásquez P, Reyes-Parada M (2018) 3D similarities between the binding sites of monoaminergic target proteins. PLoS One. 13(7):e0200637. doi: 10.1371/journal.pone.0200637.
  41. Orio P ,  Gatica M, Herzog R, Maidana JP, Castro S, and Xu K (2018) Chaos versus noise as drivers of multistability in neural networks. CHAOS. 28(10), 106321, doi: 10.1063/1.5043447
  42. Palacios-Muñoz A, Ewer J (2018) Calcium and cAMP directly modulate the speed of the Drosophila circadian clock. PLoS Genet. 14(6):e1007433. doi: 10.1371/journal.pgen.1007433
  43. Richard A, Orio P, Tanré E (2018) An Integrate-and-fire Model To Generate Spike Trains With Long-range Dependence. Journal Of Computational Neuroscience 44(3):297-312. Doi: 10.1007/s10827-018-0680-1
  44. Rimkute L, Kraujalis T, Snipas M, Palacios-Prado N, Jotautis V, Skeberdis VA and Bukauskas FF. (2018)Modulation of Connexin-36 Gap Junction Channels by Intracellular pH and Magnesium Ions. Front. Physiol. 9:362. doi: 10.3389/fphys.2018.00362
  45. Rovegno M, Sáez JC. (2018)Role of astrocyte connexin hemichannels in cortical spreading depression. Biochim Biophys Acta. 1860(1):216-223. doi: 10.1016/j.bbamem.2017.08.014
  46. Sáez J, Green C. (2018) Involvement of Connexin Hemichannels in the Inflammatory Response of Chronic Diseases. Int J Mol Sci. 19(9). pii: E2469. doi: 10.3390/ijms19092469.
  47. Sáez JC. (2018) Does Inflammatory Response Cause Tissue Dysfunction in Chronic Diseases?. In: The Proceedings of the Workshop on Cell Biology and Genetics. Edward M. De Robertis (editor). Libreria Editrice Vaticana. Vatican City. Chapter. pag 64-72
  48. Sáez JC, Contreras-Duarte S, Gómez GI, Labra VC, Santibañez CA, Gajardo-Gómez R, Avendaño BC, Díaz EF, Montero TD, Velarde V, Orellana JA. (2018) Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function. Front Immunol. 9:1899 doi: 10.3389/fimmu.2018.01899
  49. Sáez PJ, Sáez JC, Lennon-Duménil AM, Vargas (2018) Role of calcium permeable channels in dendritic cell migration. Curr Opin Immunol. 52:74-80. doi: 10.1016/j.coi.2018.04.005
  50. Schnoor B, Elhendawy A, Joseph S, Putman M, Chacón-Cerdas R, Flores-Mora D, Bravo-Moraga F, Gonzalez-Nilo F, Salvador-Morales C (2018) Engineering Atrazine Loaded Poly (lactic- co-glycolic Acid) Nanoparticles to Ameliorate Environmental Challenges. J Agric Food Chem. 66(30):7889-7898. doi: 10.1021/acs.jafc.8b01911
  51. Valdez Capuccino JM, Chatterjee P, García IE, Botello-Smith WM, Zhang H, Harris AL, Luo Y, Contreras JE. (2018) The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening. J Gen Physiol. 151(3):328-341. doi: 10.1085/jgp.201812219
  52. Vásquez-Navarrete J, Martínez AD, Ory S, Baéz-Matus X, González-Jamett AM, Brauchi S, Caviedes P, Cárdenas AM (2018) RCAN1 Knockdown Reverts Defects In The Number Of Calcium-Induced Exocytotic Events In A Cellular Model Of Down Syndrome. Front Cell Neurosci. 12:189. Doi: 10.3389/fncel.2018.00189
  53. Vilches F, Ravanal MC, Bravo-Moraga F, Gonzalez-Nilo D, Eyzaguirre J. (2018) Penicillium purpurogenum produces a novel endo-1,5-arabinanase, active on debranched arabinan, short arabinooligosaccharides and on the artificial substrate p-nitrophenyl arabinofuranoside. Carbohydr Res. 455:106-113. doi: 10.1016/j.carres.2017.11.014.
  54. Wellmann M, Álvarez-Ferradas C, Maturana CJ, Sáez JC, Bonansco C. (2018)  Astroglial Ca2+-Dependent Hyperexcitability Requires P2Y1 Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy. Front Cell Neurosci. 12:446. doi: 10.3389/fncel.2018.00446
  55. Xu K, Maidana JP, Castro S and Orio P (2018) Synchronization transition in neuronal networks composed of chaotic or non-chaotic oscillators. Scientific Reports. 8(1):8370. doi: 10.1038/s41598-018-26730-9


  1. Agurto A, Vielma AH, Cadiz B, Couve E, Schmachtenberg O. (2017) NO signaling in retinal bipolar cells. Exp Eye Res. 161:30-35. doi: 10.1016/j.exer.2017.05.013
  2. Ahumada C, Bahamondes C, Cerda CA, Silva RA, Cruz G, Moya PR, Sotomayor-Zárate R, Renard GM. (2017) Amphetamine treatment affects the extra-hypothalamic vasopressinergic system in a sex- and nucleus-dependent manner. J Neuroendocrinol. 29(4). doi: 10.1111/jne.12465
  3. Alvarez O, Carmona E, Latorre R & Gonzalez C. (2018) A Glimpse into the Permeation Pathway of the Voltage-Dependent Proton Channel (Hv1). Comments on CrossTalk 33: Proton permeation through HV1 requires/does not require transient protonation of a conserved aspartate in the S1 transmembrane helix. Journal of Physiology.
  4. Alvarez O and Latorre R. (2017)  The enduring legacy of the “constant-field equation” in membrane ion transport J Gen Physiol. 149(10):911-920. doi: 10.1085/jgp.201711839
  5. Ardiles AO, Grabrucker AM, Scholl FG, Rudenko G, Borsello T. (2017). Molecular and Cellular Mechanisms of Synaptopathies.  Neural Plast. 2017:2643943. doi: 10.1155/2017/2643943
  6. Asuaje A, Smaldini P, Martín P, Enrique N, Orlowski A, Aiello EA, Gonzalez León C, Docena G, Milesi V. (2017) The inhibition of voltage-gated H+ channel (HVCN1) induces acidification of leukemic Jurkat T cells promoting cell death by apoptosis. Pflugers Arch. 469(2):251-261. doi: 10.1007/s00424-016-1928-
  7. Berna-Erro A, Izquierdo-Serra M, Sepúlveda RV, Rubio-Moscardo F, Doñate-Macián P, Serra SA, Carrillo-Garcia J, Perálvarez-Marín A, González-Nilo F, Fernández-Fernández JM, Valverde MA (2017) Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel. Sci Rep. 7(1):10522. doi: 10.1038/s41598-017-11274-1
  8. Calbiague VM, Olivares J, Olivares E, Schmachtenberg O (2017) The Chilean Recluse Spider (Araneae: Sicariidae) Displays Behavioral Responses to Conspecific Odors, but Not to Several General Odorants. J Med Entomol. 54(5):1435-1439. doi: 10.1093/jme/tjx101
  9. Cárdenas AM, Fernández-Olivares P, Díaz-Franulic I, González-Jamett AM, Shimahara T, Segura-Aguilar J, Caviedes R, Caviedes P. (2017) Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome). Neurotox Res. 32(4):614-623. doi: 10.1007/s12640-017-9775-0
  10. Castillo K, Diaz-Franulic I, Canan J, Gonzalez-Nilo F and Latorre R. (2017) Thermally-activated TRP channels: Molecular sensors for temperature detection. Physical Biology. 15(2):021001. doi: 10.1088/1478-3975/aa9a6f.
  11. Castillo K, Valenzuela V, Oñate M and Hetz C. 2016. A molecular reporter for monitoring autophagic flux in nervous system in vivo. Methods in Enzymology 588:109-131. doi: 10.1016/bs.mie.2016.09.077
  12. Castro-Severyn J, Remonsellez F, Valenzuela SL, Salinas C, Fortt J, Aguilar P, Pardo-Esté C, Dorador C, Quatrini R, Molina F, Aguayo D, Castro-Nallar E, Saavedra CP. (2017) Comparative Genomics Analysis of a New Exiguobacterium Strain from Salar de Huasco Reveals a Repertoire of Stress-Related Genes and Arsenic Resistance. Front Microbiol. 8:456. doi: 10.3389/fmicb.2017.00456.
  13. Charvériat M, Naus CC, Leybaert L, Sáez JC, Giaume C. (2017) Connexin-Dependent Neuroglial Networking as a New Therapeutic Target. Front Cell Neurosci. 11:174. doi: 10.3389/fncel.2017.00174. eCollection 2017. Review.
  14. Couve E, Lovera M, Suzuki K, Schmachtenberg O. (2017) Schwann cell phenotypes in the aging human dental pulp. J Dental Res. 97(3):347-355. doi: 10.1177/002203451773396
  15. Duran-Aniotz C, Cornejo V, Espinoza S, Ardiles AO, Medinas D, Salazar C, Foley A, Gajardo I, Thielen P, Iwawaki T, Scheper W, Soto C, Palacios AG, Hoozemans J, Hetz C. (2017) IRE1 Signaling exacerbates Alzheimer’s disease pathogenesis. Acta Neuropathologica. doi: 10.1007/s00401-017-1694-x
  16. Escobar AP (2017) The Role of Kappa Opioid Receptors in Glutamate Input Selection in the Ventral Striatum. J Neurosci. 2017 Nov 15;37(46):11072-11073 Doi: 10.1523/JNEUROSCI.2381-17.2017
  17. Espinosa N, Alonso A, Morales C, Espinosa P, Chávez AE, Fuentealba P. (2017) Basal Forebrain Gating by Somatostatin Neurons Drives Prefrontal Cortical Activity. Cereb cortex. 29(1):42-53. doi: 10.1093/cercor/bhx302
  18. Gajardo-Gómez R, Labra VC, Maturana CJ, Shoji KF, Santibañez CA, Sáez JC, Giaume C, Orellana JA. (2016)  Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels: A neuroprotective mechanism. Glia. 65(1):122-137. doi: 10.1002/glia.23080.
  19. Giaume C, Sáez JC, Song W, Leybaert L, Naus CC. (2017) Connexins and pannexins in Alzheimer’s disease. Neurosci Lett. 695:100-105 doi: 10.1016/j.neulet.2017.09.006
  20. González A, Herrera G, Ugarte G, Restrepo C, Piña R, Pertusa M, Orio P, Madrid R. (2017) IKD Current in Cold Transduction and Damage-Triggered Cold Hypersensitivity. Adv Exp Med Biol. 2017;1015:265-277. doi: 10.1007/978-3-319-62817-2_14.
  21. González A, Ugarte G, Restrepo C, Herrera G, Piña R, Gómez-Sánchez JA, Pertusa M, Orio P, Madrid R. (2017) Role of the excitability brake potassium current IKD in cold allodynia induced by chronic peripheral nerve injury. J Neurosci. 37 (12) 3109-3126; doi: 10.1523/JNEUROSCI.3553-16.2017.
  22. González LF, Henríquez-Belmar F, Delgado-Acevedo C, Cisternas-Olmedo M, Arriagada G, Sotomayor-Zárate R, Murphy DL, Moya PR. (2017) Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice. Biol Res. 50(1):29. doi: 10.1186/s40659-017-0138-3.
  23. González-Jamett AM, Baez-Matus X, Olivares MJ, Hinostroza F, Guerra-Fernández MJ, Vasquez-Navarrete J, Thao Bui M, Guicheney P, Romero NB, Bevilacqua JA, Bitoun M, Caviedes P, Cárdenas AM. (2017).  Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells. Scientific Reports. 7(1):4580 doi: 10.1038/s41598-017-04418-w
  24. González-Jamett AM , Guerra MJ , Olivares MJ , Haro-Acuña V , Baéz-Matus X , Vásquez-Navarrete J, Momboisse F , Martinez-Quiles N, Cárdenas AM. (2017). The F-Actin Binding Protein Cortactin Regulates the Dynamics of the Exocytotic Fusion Pore through its SH3 Domain. Front. Cell. Neurosci., doi: 10.3389 /fnc el.2017.00130
  25. Gutierrez-Maldonado SE, Garate JA, Retamal MJ, Cisternas MA, Volkmann UG, Pérez-Acle T (2017) Accessing the structural and thermodynamic properties of ultra-thin layers of C32 adsorbed on a SiO2 surface. Chemical Physics Letters. 674: 64–70. doi: 10.1016/j.cplett.2017.01.065
  26. Hashimotodani Y, Nasrallah K, Jensen KR, Chávez AE, Carrera D, Castillo PE. (2017) LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron. 95(4):928-943.e3. doi: 10.1016/j.neuron.2017.07.028.
  27. Latorre R, Castillo K, Carrasquel-Ursulaez W, Sepulveda RV, Gonzalez-Nilo FGonzalez C and Alvarez O. 2016. Molecular determinants of BK channel functional diversity and functioning. Physiological Reviews, 97(1):39-87 doi:10.1152/physrev.00001.2016
  28. Manzanares D, Araya-Durán I, Gallego-Yerga L, Játiva P, Márquez-Miranda V, Canan J, Jiménez Blanco JL, Mellet CO, González-Nilo FD, García Fernández JM, Ceña V. (2017) Molecular determinants for cyclo-oligosaccharide-based nanoparticle-mediated effective siRNA transfection. Nanomedicine (Lond). 12(13):1607-1621. doi: 10.2217/nnm-2017-0123.
  29. Márquez-Miranda V, Abrigo J, Rivera JC, Araya-Durán I, Aravena J, Simon F, Pacheco N, González-Nilo FD, Cabello-Verrugio C.  (2017) The complex of PAMAM-OH dendrimer with Angiotensin (1-7) prevented the disuse-induced skeletal muscle atrophy in mice. Int J Nanomedicine. 12:1985-1999. doi: 10.2147/IJN.S125521.
  30. Márquez-Miranda V, Araya-Durán I, Gonzalez-Nilo FD. (2017). Multiescale molecular simulations applied to nucleic acid- dendrimer interactions studies. Curr Pharm Des. 23(21):3062-3075. doi: 10.2174/1381612823666170306093224.
  31. Martin AJ, Contreras-Riquelme S, Dominguez C, Perez-Acle T. (2017) LoTo: a graphlet based method for the comparison of local topology between gene regulatory networks. PeerJ. 5:e3052. doi: 10.7717/peerj.3052.
  32. Maturana CJ, Aguirre A, Sáez JC. (2016) High glucocorticoid levels during gestation activate the inflammasome in hippocampal oligodendrocytes of the offspring. Dev Neurobiol. 77(5):625-642. doi: 10.1002/dneu.22409
  33. Muñoz PA, Márquez SL, Gonzalez-Nilo FD, Márquez-Miranda V, Blamey JM. (2017) Structure and application of antifreeze proteins from Antarctic bacteria. Microb Cell Fact. 16(1):138. doi: 10.1186/s12934-017-0737-2
  34. Palacios AG, Escobar M J. and Céspedes E. (2017) Missing colors: The enactivist approach to perception. Constructivist Foundations. 13(1): 117–125.
  35. Palacios AG, Escobar MJ, Céspedes E (2017). Authors’ Response: Is a Weak Notion of Representation not Compatible with a Contextualist and Enactivist Account of Perception?. Constructivist Foundations, 13 (1): 135-140
  36. Palominos MF, Verdugo L, Gabaldon C, Pollak B, Ortíz-Severín J, Varas MA, Chávez FP, Calixto A. (2017) Transgenerational Diapause as an Avoidance Strategy against Bacterial Pathogens in Caenorhabditis elegans. MBio. 2017 Oct 10;8(5). pii: e01234-17. doi: 10.1128/mBio.01234-17.
  37. Peñaloza JP, Márquez-Miranda V, Cabaña-Brunod M, Reyes-Ramírez R, Llancalahuen FM, Vilos C, Maldonado-Biermann F, Velásquez LA, Fuentes JA, González-Nilo FD, Rodríguez-Díaz M, Otero C. (2017) Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines. J Nanobiotechnology. 15(1):1. doi: 10.1186/s12951-016-0241-6.
  38. Pérez-Acle T, Fuenzalida I, Martin AJM, Santibañez R, Avaria R, Bernardin A, Bustos AM, Garrido D, Jonathan Dushoff, Liu JH. (2017) Stochastic simulation of multiscale complex systems with PISKaS: A rule-based approach. Biochem Biophys Res Commun. 498(2):342-351. doi: 10.1016/j.bbrc.2017.11.138
  39. Pinto BI, Pupo A, García IE, Mena-Ulecia K, Martínez ADLatorre RGonzalez C. (2017) Calcium binding and voltage gating in Cx46 hemichannels. Sci Rep. 7(1):15851. doi: 10.1038/s41598-017-15975-5
  40. Plotkin LI, Davis HM, Cisterna BA, Sáez JC. (2017) Connexins and Pannexins in Bone and Skeletal Muscle. Curr Osteoporos Rep. 15(4):326-334. doi: 10.1007/s11914-017-0374-z. Review
  41. Puebla C, Retamal MA, Acuña R, Sáez JC. (2017) Regulation of Connexin-Based Channels by Fatty Acids. Front Physiol. 8:11. doi: 10.3389/fphys.2017.00011. Review.
  42. Rubat S, Varas I, Sepúlveda R, Almonacid D, Gonzalez-Nilo F, Agosin E (2017) Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase. FEMS Yeast Res. 17(4). doi: 10.1093/femsyr/fox032.
  43. Sáez JC. (2017) Unravelling a novel mechanism for the up-regulation of connexin43 gap junctions between cells derived from the blood-brain barrier. J Physiol. 595(8):2411-2412. doi: 10.1113/JP274027
  44. Sáez PJ, Vargas P, Shoji KF, Harcha PA, Lennon-Duménil AM, Sáez JC (2017) ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X7 receptors. Sci Signal. 10(506). pii: eaah7107. doi: 10.1126/scisignal.aah710
  45. Salazar J, Alarcón M, Huerta J, Navarro B, Aguayo D. (2017) Phosphoethanolamine addition to the Heptose I of the Lipopolysaccharide modifies the inner core structure and has an impact on the binding of Polymyxin B to the Escherichia coli outer membrane. Arch Biochem Biophys. 620:28-34. doi: 10.1016/
  46. Sampogna-Mireles D, Araya-Durán ID, Márquez-Miranda V, Valencia-Gallegos JA, Gonzalez-Nilo FD (2017) Structural analysis of binding functionality of folic acid-PEG dendrimers against folate receptor. J Mol Graph Model. 72:201-208. doi:10.1016/j.jmgm.2017.01.004.
  47. Selcho M, Millán C, Palacios-Muñoz A, Ruf F, Ubillo L, Chen J, Bergmann G, Ito C, Silva V, Wegener C, Ewer J. (2017) Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila. Nat Commun. 8:15563. doi: 10.1038/ncomms15563.
  48. Vargas AA, Cisterna BA, Saavedra-Leiva F, Urrutia C, Cea LA, Vielma AH, Gutierrez-Maldonado SE, Martin AJ, Pareja-Barrueto C, Escalona Y, Schmachtenberg O, Lagos CF, Perez-Acle T, Sáez JC. (2017) On Biophysical Properties and Sensitivity to Gap Junction Blockers of Connexin 39 Hemichannels Expressed in HeLa Cells. Front Physiol. 8:38. doi: 10.3389/fphys.2017.00038.
  49. Vega-Zuniga T, Medina FS, Marín G, Letelier JC, Palacios AG, Němec P, Schleich CE, Mpodozis J. (2017) Selective binocular vision loss in two subterranean caviomorph rodents: Spalacopus cyanus and Ctenomys talarum. Sci Rep. 7:41704. doi: 10.1038/srep41704.
  50. Villanelo F, Escalona Y, Pareja-Barrueto C, Garate JA, Skerrett IM, Perez-Acle T (2017) Accessing gap-junction channel structure-function relationships through molecular modeling and simulations. .BMC Cell Biol. 18(Suppl 1):5. doi: 10.1186/s12860-016-0121-9. Review.
  51. Wongsamitkul N, Maldifassi MC, Simeone X, Baur R, Ernst M, Sigel E (2017) α subunits in GABAA receptors are dispensable for GABA and diazepam action. Sci Rep. 7(1):15498. doi: 10.1038/s41598-017-15628-7.
  52. Xu K., Maidana JP, Caviedes M, Quero D, Aguirre P and Orio P. (2017). Hyperpolarization-activated current induces period-doubling cascades and chaos in a cold thermoreceptor model. Front Comp Neurosci. 11:12. doi: 10.3389/fncom.2017.00012. eCollection 2017
  53. Yi C, Ezan P, Fernández P, Schmitt J, Sáez JC, Giaume C, Koulakoff A. (2017) Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer’s disease. Glia. 65(10):1607-1625. doi: 10.1002/glia.23182
  54. Zhong G, Akoum N, Appadurai DA, Hayrapetyan V, Ahmed O, Martinez AD, Beyer EC, Moreno AP. (2017) Mono-Heteromeric Configurations of Gap Junction Channels Formed by Connexin43 and Connexin45 Reduce Unitary Conductance and Determine both Voltage Gating and Metabolic Flux Asymmetry. Front Physiol. 8:346. doi: 10.3389/fphys.2017.00346.


  1. Acevedo W, González-Nilo F, Agosin E. (2016) Docking and Molecular Dynamics of Steviol Glycoside-Human Bitter Receptor Interactions. J Agric Food Chem. 64(40):7585-7596
  2. Aliaga C, Bravo-Moraga F, Gonzalez-Nilo D, Márquez S, Lühr S, Mena G, Rezende MC. (2016) Location of TEMPO derivatives in micelles: subtle effect of the probe orientation. Food Chem. 192:395-401
  3. Aspé-Sánchez M, Moreno M, Rivera MI, Rossi A and Ewer J. (2016) Oxytocin and vasopressin receptor gene polymorphisms: role in social and psychiatric traits Frontiers in Neuroscience 28;9:510. doi: 10.3389/fnins.2015.00510
  4. Boetsch C, Aguayo-Villegas DR, Gonzalez-Nilo FD, Lisa ÁT, Beassoni PR. (2016) Putative binding mode of Escherichia coli exopolyphosphatase and polyphosphates based on a hybrid in silico/biochemical approach. Arch Biochem Biophys. 606:64-72. doi: 10.1016/
  5. Bousquet F, Chauvel I, Flaven-Pouchon J, Farine JP, Ferveur JF. (2016) Dietary rescue of altered metabolism gene reveals unexpected Drosophila mating cues. J Lipid Res. 57(3):443-50. doi: 10.1194/jlr.M064683.
  6. Calfún C, Domínguez C, Pérez-Acle TWhitlock KE. (2016) Changes in Olfactory Receptor Expression Are Correlated With Odor Exposure During Early Development in the zebrafish (Danio rerio). Chem Senses. 1861(5):439-48
  7. Cárdenas AM, González-Jamett AM, Cea LA, Bevilacqua JA, Caviedes P. (2016) Dysferlin function in skeletal muscle: Possible pathological mechanisms and therapeutical targets in dysferlinopathies. Exp Neurol. Exp Neurol. 283(Pt A):246-254. doi: 10.1016/j.expneurol.2016.06.026
  8. Cárdenas AM, Marengo F. (2016) How the stimulus defines the dynamics of vesicle pool recruitment, fusion mode and vesicle recycling in neuroendocrine cells. J Neurochem. 137(6):867-79. doi: 10.1111/jnc.13565
  9. Castillo JP, Sánchez-Rodríguez JE, Clark Hyde H, Zaelzer CA, Aguayo D, Sepúlveda R, Luk LYP, Kent S, Gonzalez-Nilo F, Bezanilla F, and Latorre R. (2016) β1 Subunit-Induced Structural Rearrangements of the Ca2+- and Voltage-Activated (BK) Channel.  Proc. Natl Acad Sci (USA). 113(23):E3231-9
  10. Cea LA, Balboa E, Puebla C, Vargas AA, Cisterna BA, Escamilla R, Regueira T, Sáez JC. (2016) Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels. Biochim Biophys Acta. 1862(10):1891-9. doi: 10.1016/j.bbadis.2016.07.003
  11. Cea LA, Bevilacqua JA, Arriagada C, Cárdenas AM, Bigot A, Mouly VSáez JC, Caviedes P. (2016) The absence of dysferlin induces the expression of functional connexin-based hemichannels in human myotubes. BMC Cell Biol. 17 Suppl 1:15. doi: 10.1186/s12860-016-0096-6.
  12. Cea LA, Puebla C, Cisterna BA, Escamilla R, Vargas AA, Frank M, Martínez-Montero P, Prior C, Molano J, Esteban-Rodríguez I, Pascual I, Gallano P, Lorenzo G, Pian H, Barrio LC, Willecke K, Sáez JC. (2016) Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis. Cell Mol Life Sci. 73(13):2583-99. doi: 10.1007/s00018-016-2132-2
  13. Chávez Andrés E. (2016) ¿Cómo afecta el color al comportamiento?: Una mirada a la visón ultravioleta en mamíferos. Anales Museo de Historia Natural de Valparaíso. Volumen 29, páginas 21-24.
  14. Chetty S, Bhakat S, Martin AJ, Soliman ME. (2016) Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights. J Biomol Struct Dyn. 34(1):135-51.
  15. Cisterna BA, Vargas AA, Puebla C, Sáez JC. (2016) Connexin hemichannels explain the ionic imbalance and lead to atrophy in denervated skeletal muscles. Biochim Biophys Acta. 1862(11):2168-2176. doi: 10.1016/j.bbadis.2016.08.020
  16. Diao F, Mena W, Shi J, Park D, Diao F, Taghert P, Ewer J, and White BH. The splice Isoforms of the Drosophila Ecdysis Triggering Hormone receptor have developmentally distinct roles. Genetics, 202(1):175-89
  17. Díaz J, Woudt L, Suazo L, Garrido C, Caviedes P, Cárdenas AM, Castiglioni C, Bevilacqua JA. (2016) Broadening The Imaging Phenotype of Dysferlinopathy at Different Disease Stages. Muscle Nerve. 54(2):203-10. doi: 10.1002/mus.25045
  18. Diaz-Franulic I, Caceres-Molina J, Sepúlveda RV, Gonzalez-Nilo F, and Latorre R  (2016) Structurally driven pharmacology pf transient receptor potential vanilloid1 (TRPV1) channel. Mol Pharm. 90(3):300-8
  19. Diaz-Franulic I, Poblete H, Miño G, González C, and Latorre R (2016) Allosterism and Structure in Thermally Activated Transient Receptor Potential Channels Ann. Rev. Biophys. 45:371-98
  20. English NJ and Garate JA (2016) Near-microsecond human aquaporin 4 gating dynamics in static and alternating external electric elds: Non-equilibrium molecular dynamics. J Chem Phys. 145(8):085102. doi: 10.1063/1.4961072
  21. Escalona Y, Garate JA, Araya-Secchi R, Huynh T, Zhou R, Perez-Acle T. (2016) Exploring the Membrane Potential of Simple Dual-Membrane Systems as Models for Gap-Junction Channels. Biophys J. 110(12):2678-88. doi: 10.1016/j.bpj.2016.05.005.
  22. Ewer J. (2016) Como elegir un horario para Chile. Anales Museo de Historia Natural de Valparaíso. Volumen 29, páginas 9-13.
  23. Fernández A, Pupo A, Mena-Ulecia K and Gonzalez C (2016) Pharmacological modulation of proton channel Hv1 in cancer therapy: Future perspectives Mol Pharmacol 90(3):385-402
  24. Flaven-Pouchon J, Farine JP, Ewer J, Ferveur JF.(2016) Regulation of cuticular hydrocarbon profile maturation by Drosophila tanning hormone, bursicon, and its interaction with desaturase activity. Insect Biochem Mol Biol. 79:87-96. doi: 10.1016/j.ibmb.2016.10.007
  25. Garate JAPérez-Acle T. (2016) From dimers to collective dipoles: Structure and dynamics of methanol/ethanol partition by narrow carbon nanotubes. J Chem Phys. 144(6):064105
  26. García IE, Bosen F, Mujica P, Pupo A, Flores-Muñoz C, Jara O, Gonzalez C, Willecke K and Martinez AD (2016) From Hyperactive Connexin26 Hemichannels to Impairments in Epidermal Calcium Gradient and Permeability Barrier in the Keratitis-Ichthyosis-Deafness Syndrome J Invest Dermatol.  136(3):574-83
  27. García IE, Prado P, Pupo A, Jara O, Rojas-Gómez D, Mujica P, Flores-Muñoz C, González-Casanova J, Soto-Riveros C, Pinto BI, Retamal MA, Gonzalez C and Martinez AD (2016) Connexinopathies: a structural and functional glimpse. BMC Cell Biology. 17 Suppl 1:17. Doi: 10.1186/s12860-016-0092-x
  28. Graham Z, Collier L, QinW, Peng Y, Sáez JC , Bauman WA and Christopher Cardozo. (2015) J A soluble activin receptor IIB fails to prevent muscle atrophy in a mouse model of spinal cord injury. J Neurotrauma 33(12):1128-35. doi: 10.1089/neu.2015.405
  29. Johnson RG, Le HC, Evenson K, Loberg SW, Myslajek TM, Prabhu A, Manley AM, O’Shea C, Grunenwald H, Haddican M, Fitzgerald PM, Robinson T, Cisterna BA, Sáez JC, Liu TF, Laird DW, Sheridan JD. (2016) Connexin Hemichannels: Methods for Dye Uptake and Leakage. J Membr Biol.249(6):713-741
  30. Krick S, Wang J, St-Pierre M, Gonzalez C, Dahl G, Salathe M. (2016) Duox2 Regulates Pannexin1-mediated ATP Release in Primary Human Airway Epithelial Cells via changes in intracellular pH and not H2O2 production. J Biol Chem. 291(12):6423-32. doi: 10.1074/jbc.M115.664854.
  31. Lions S and Peña M Reading Comprehension in Latin America: Difficulties and Possible Interventions New Dir Child Adolesc Dev. 2016(152):71-84. doi: 10.1002/cad.20158.
  32. Márquez-Miranda V, Araya-Durán I, Camarada MB, Comer J, Valencia-Gallegos JA, Gonzalez-Nilo F. (2016) Self-Assembly of Amphiphilic Dendrimers: The Role of Generation and Alkyl Chain Length in siRNA Interaction. Sci Rep. 2016 Jul 5;6:29436. doi: 10.1038/srep29436.
  33. Márquez-Miranda V, Peñaloza JP, Araya-Durán I, Reyes R, Vidaurre S, Romero V, Fuentes J, Céric F, Velásquez L, Gonzalez-Nilo F, Otero C. (2016) Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake. Nanoscale Res Lett. 2016 Dec;11(1):66.
  34. Marracino P, Liberti M, Trapani E, Burnham CJ, Avena M, Garate JA, Apollonio F, English NJ. (2016) Human Aquaporin 4 Gating Dynamics under Perpendicularly-Oriented Electric-Field Impulses: A Molecular Dynamics Study. Int J Mol Sci. 17(7). pii: E1133. doi: 10.3390/ijms17071133.
  35. Martin AJ, Dominguez C, Contreras-Riquelme S, Holmes DS, Perez-Acle T. (2016) Graphlet Based Metrics for the Comparison of Gene Regulatory Networks. PLoS One. 2016 Oct 3;11(10):e0163497. doi: 10.1371/journal.pone.0163497.
  36. Martínez AD, Jara O, Ceriani R, Maripillán J, Mujica P, García IE (2016) Methods to determinate formation of heteromeric hemichannels. Book title: Gap Junction and Pannexin Channels “A Volume in the Methods in Signal Transduction Series”. Chapter 11.
  37. Martínez G, Vidal RL, Mardones P, Serrano FG, Ardiles AO, Wirth C, Valdés P, Thielen P, Schneider BK, Kerr B, Valdés JL, Palacios AG, Inestrosa NC, Glimcher LH, Hetz C. Regulation of memory formation by the transcription factor XBP1. (2015). Cell-Report.14(6):1382-9
  38. Mena W, Diegelmann S, Wegener C, Ewer J. (2016) Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulators. Elife. 2016 Dec 15;5. pii: e19686. doi: 10.7554/eLife.19686.
  39. Moldenhauer H, Díaz-Franulic I , Gonzalez-Nilo F, Naranjo D (2016). Effective pore size and radius of capture for K+ ions in K-channels. Scientific Reports. 6:1989
  40. Moya-Díaz J, Álvarez JD, Montenegro M, Bayonés L, Belingheri AV, González-Jamett AM, Cárdenas AM, Marengo FD (2016) Sustained exocytosis after action potential-like stimulation at low frequencies in mouse chromaffin cells depends on a dynamin-dependent fast endocytotic process. Front Cell Neurosci. 10:184. doi: 10.3389/fncel.2016.00184
  41. Moya Vera PR. (2016) Interacciones genético-ambientales en el comportamiento. Anales Museo de Historia Natural de Valparaíso. Volumen 29, páginas 28-32.
  42. Muñoz P, Estay C, Díaz P, Elgueta C, Ardiles ÁO, Lizana PA (2016)Inhibition of DNA Methylation Impairs Synaptic Plasticity during an Early Time Window in Rats. Neural Plast. 2016:4783836. doi: 10.1155/2016/4783836.
  43. Naranjo D, Moldenhauer H, Pincuntureo M. and Díaz-Franulic I (2016) Pore size matters for potassium channel conductance. J Gen Physiol 148(4):277-91. doi: 10.1085/jgp.201611625.
  44. Olivares, J. (2016) Reseña bibliográfica sobre la araña de rincón (Loxosceles Laeta, Fam. Sicariirae): Que sabemos y que necesitamos saber. Anales Museo de Historia Natural de Valparaíso. Volumen 29, páginas 53-56.
  45. Park J, Chávez AE, Mineur YS, Morimoto-Tomita M, Lutzu S, Kim KS, Picciotto MR, Castillo PE, Tomita S. (2016) CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory. Neuron. 92(1):75-83. doi: 10.1016/j.neuron.2016.09.002
  46. Pérez-Núñez R, Barraza N, Gonzalez-Jamett A, Cárdenas AM, Barnier JV, Caviedes P. (2016) Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension. Neurotox Res. 30(1):76-87. doi: 10.1007/s12640-016-9613-
  47. Pinto BI, García IE, Pupo A, Retamal MA, Martinez AD, Latorre R and Gonzalez C (2016) Charged residues at the first transmembrane region contribute to the voltage dependence of connexins slow gate. J Biol Chem 291(30):15740-52. doi: 10.1074/jbc.M115.709402
  48. Puebla C, Cisterna BA, Salas DP, Delgado-López F, Lampe PD, Sáez JC. (2016) Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism. Biochim Biophys Acta. 1861(5):439-48
  49. Qiu F, Chamberlin A, Watkins BM, Ionescu A, Perez ME, Barro-Soria R, González C, Noskov SY and Larsson HP (2016) Molecular mechanism of Zn2+ inhibition of a voltage-gated proton channel. Proc Natl Acad Sci U S A 113(40):E5962-E5971
  50. Retamal MA, García IE, Pinto B, Pupo A, Baez-Nieto D, Stehberg J, Del Rio R, Gonzalez C. (2016) Extracellular cysteine in connexins: role as redox sensors. Front in Physiol 7:1
  51. Sáez JC. (2016) Proceedings of the International Gap Junction Conference 2015. BMC Cell Biol. 17 Suppl 1:18. doi: 10.1186/s12860-016-0097-5
  52. Salazar C, Valdivia G, Ardiles AO, Ewer J, Palacios AG. (2016). Genetic variants associated with neurodegenerative Alzheimer disease in natural model. Biological Research. Special Issue. 26;49(1):14
  53. Salvador-Morales C, Brahmbhatt B, Márquez-Miranda V, Araya-Duran I, Canan J, Gonzalez-Nilo F, Vilos C, Cebral J, Mut F, Lohner R, Leong B, Sundaresan G, Zweit J. (2016) Mechanistic Studies on the Self-Assembly of PLGA Patchy Particles and Their Potential Applications in Biomedical Imaging. Langmuir. 32(31):7929-42. doi: 10.1021/acs.langmuir.6b02177
  54. Savalli N, Pantazis A,Sigg D, Weiss JN, Neely A and Olcese R (2016) The α2δ-1 subunit remodels CaV1.2 voltage sensors and allows Ca2+ influx at physiological membrane potentials J Gen Physiol. 148(2):147-59. doi: 10.1085/jgp.201611586
  55. Sepúlveda-Crespo D, Vacas-Córdoba E, Márquez-Miranda V, Araya-Durán I, Gómez R, Mata FJ, González-Nilo FD, Muñoz-Fernández MÁ. (2016) Effect of Several HIV Antigens Simultaneously Loaded with G2-NN16 Carbosilane Dendrimer in the Cell Uptake and Functionality of Human Dendritic Cells. Dec 21;27(12):2844-2849. doi: 10.1021/acs.bioconjchem.6b00623.
  56. Valdés J, Trachsel-Moncho L, Sahaboglu A, Trifunovic D, Miranda M, Ueffing M, Paquet-Durand F, Schmachtenberg O (2016). Organotypic retinal explant cultures as in vitro alternative for diabetic retinopathy studies. ALTEX,33(4):459-464
  57. Vielma, A.H. and Schmachtenberg, O. Electrophysiological fingerprints of OFF bipolar cells in rat retina. Sci. Rep.,6:30259 doi: 10.1038/srep30259
  58. Wang H, Ardiles A, Yang S, Valdivia G, Baek M, Tran T, Posada-Duque R, Chuang YA, Palacios AG, Gallagher M, Worley P, Kirkwood A. (2016). Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the hippocampus. Journal of Neuroscience 36(5):1723-9


  1. Aguayo D, Pacheco N, Morales EH, Collao B, Luraschi R, Cabezas C, Calderón P, Gonzalez-Nilo F, Gil F, Calderón IL, Saavedra CP (2015) Hydrogen peroxide and hypochlorous acid influx through the major S. Typhimurium porin OmpD is affected by substitution of key residues of the channel.  Arch Biochem Biophys. 568:38-45 Doi: 10.1016/
  2. Arias-Darraz L, Cabezas D, Colenso CK, Alegría-Arcos M, Bravo-Moraga F, Varas-Concha I, Almonacid DE, Madrid R, Brauchi S. (2015) A transient receptor potential ion channel in Chlamydomonas shares key features with sensory transduction-associated TRP channels in mammals. Plant Cell. 27(1):177-88. Doi: 10.1105/tpc.114.131862.
  3. Brennan MJ, Karcz J, Vaughn NR, Woolwine-Cunningham Y, DePriest AD, Escalona Y, Pérez-Acle T, Skerrett IM (2015) Tryptophan Scanning Reveals Dense Packing of Connexin Transmembrane Domains in Gap Junction Channels Composed of Connexin32. J Biol Chem. 290(28):17074-84 Doi: 10.1074/jbc.M115.650747
  4. Camarada MB, Márquez-Miranda V, Araya-Durán I, Yévenes A, Gonzalez-Nilo F. (2015) PAMAM G4 dendrimers as inhibitors of the iron storage properties of human L-chain ferritin. Phys Chem Chem Phys. 17(29):19001-11. Doi: 10.1039/c5cp02594j
  5. Carrasquel-Ursulaez W, Contreras GF, Sepúlveda R, Aguayo D, Gonzalez-Nilo FGonzalez C and Latorre R. (2015) Hydrophobic interaction between contiguous residues in the S6 transmembrane segment acts as a stimuli integration node in the BK channel.  J Gen Physiol. 145(1):61-74. Doi: 10.1085/jgp.201411194
  6. Carrasquel-Ursulaez W, Moldenhauer H, Castillo JP, Latorre R & Alvarez O. (2015) Biophysical analysis of thermosensitive TRP channels with a special focus on the cold receptor TRPM8.  Temperature. 145(1):61-74. oi: 10.1080/23328940.2015.1047558
  7. Castillo, JP, Rui, H, Basilio, D, Das, A, Roux, B, Latorre R, Bezanilla, F, Holmgren, M. (2015). Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase. Nature Comm. 6:7622. oi: 10.1038/ncomms8622
  8. Castillo K, Contreras GF, Pupo A, Torres Y, Neely A, Gonzalez C and Latorre R. (2015) Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels. Proc Natl Acad Sci U S A. 112(15):4809-14. Doi: 10.1073/pnas.1504378112
  9. Castillo K, Pupo A, Baez-Nieto D, Contreras G; Morera FJ, Neely ALatorre R, Gonzalez C. (2015) Voltage-Gated Proton (Hv1) Channels, a Singular Voltage Sensing Domain. FEBS Letters . 589(22):3471-8 Doi: 10.1016/j.febslet.2015.08.003.
  10. Cerquera A, Muñoz J, Araya J, Gómez O (2015) Registro de actividad eléctrica en la retina de una rata albina empleando una matriz de microelectrodos. Acta biológica colombiana 20(3):37-46. Doi: 10.15446/abc.v20n3.46216
  11. Cortés-Campos C, Letelier J, Ceriani R, Whitlock KE. (2015). Zebrafish adult-derived hypothalamic neurospheres generate gonadotropin-releasing hormone (GnRH) neurons. Biol Open 4(9):1077-86. oi: 10.1242/bio.010447
  12. Diao F, Ironfield H, Diao F, Luan H, Shropshire W, Ewer J,  Marr E, Potter CJ, Landgraf M and White BH (2015) Plug-and-Play Genetic Access to Drosophila Cell Types Using Exchangeable Exon Cassettes. Cell Reports. 10(8):1410-21. Doi: 10.1016/j.celrep.2015.01.059
  13. Díaz-Franulic, I., Sepúlveda R, Navarro-Quezada N, F. Gonzalez-Nilo FD and Naranjo D. (2015).  Pore dimensions and the role of occupancy in unitary conductance of Shaker K-channels. The Journal of General Physiology.146:133-146. Doi: 10.1085/jgp.201411353.
  14. Du LY, Chang LY, Ardiles AO, Tapia-Rojas C, Araya J, Inestrosa NC, Palacios AG, Acosta ML. (2015) Alzheimer’s disease-related protein expression in the retina of Octodon degus. PLoS One. 2015 Aug 12;10(8):e0135499. oi: 10.1371/journal.pone.0135499
  15. Duran-Lara EF, Avila-Salas F, Galaz S, John A, Marican A, Gutierrez M, Nachtigall FM, Gonzalez-Nilo FD, Santos LS. (2015) Nano-Detoxification Of Organophosphate Agents By PAMAM Derivatives. J Braz Chem Soc 26(3): 580-91. Doi: 10.5935/0103-5053.20150013
  16. Durán-Lara EF, López-Cortés XA, Castro RI, Avila-Salas F, Gonzalez-Nilo FD, Laurie VF, Santos LS. (2015) Experimental and theoretical binding affinity between polyvinylpolypyrrolidone and selected phenolic compounds from food matrices.  Food Chem. 168:464-70. oi: 10.1016/j.foodchem.2014.07.048
  17. Elgueta C, Vielma AH, Palacios AG and Schmachtenberg O. (2015) Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Front. Cell. Neurosci. 9:6 Doi: 10.3389/fncel.2015.00006
  18. Ferreira G, Raddatz N, Lorenzo Y, Gonzalez C and Latorre R (2015) Biophysical and Molecular Features of Thermosensitive TRP Channels Involved in Sensory Transduction . Cahpter in: TRP Channels in Sensory Transduction, R. Madrid, J. Bacigalupo (eds.). Springer International Publishing Switzerland
  19. García IE, Maripillán J, Jara O, Ceriani R, Palacios-Muñoz A, Ramachandran J, Olivero P, Pérez-Acle T, Gonzalez C, Sáez JC, Contreras JE, Martinez AD. (2015)Keratitis-ichthyosis-deafness syndrome-associated Cx26 mutants produce nonfunctional gap junctions but hyperactive hemichannels when co-expressed with wild type Cx43. J Invest Dermatol. 135(5):1338-47. oi: 10.1038/jid.2015.20
  20. Garcia-Elias A, Berna-Erro A, Rubio-Moscardo F, Pardo-Pastor C, Mrkonjić S, Sepúlveda RV, Vicente R, Gonzalez-Nilo F, Valverde MA. (2015) Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels. Structure. 23(8):1404-13. Doi: 10.1016/j.str.2015.05.018
  21. García-Puente Y, Prado-Gutiérrez P, Martínez-Montes E (2015) Time-frequency methods for studying non-stationary auditory responses. IFMBE Proceedings.  49: 540-543.
  22. García-Puente Y, Prado-Gutiérrez P, Martínez-Montes (2015) Evaluación de métodos para la estimación de la respuestaauditiva de seguimiento de la modulación. CENIC Ciencias Biologicas.
  23. Harcha PA, Vargas A, Yi C, Koulakoff AA, Giaume C, Sáez JC . (2015) Hemichannels Are Required for Amyloid β-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice. J Neurosci. 35(25):9526-38. Doi: 10.1523/JNEUROSCI.3686-14.2015
  24. Inestrosa NC, Rios JA, Cisternas P, Tapia-Rojas C, Rivera D, Braidy N, Zolezzi JM, Godoy JA, Carvajal FJ, Ardiles AO, Bozinovic F, Palacios AG, Sachdev PS. (2015). Age progression of neuropathological markers in the brain of the Chilean rodent Octodon degus, a natural model of Alzheimer’s disease. Brain Pathology. 25(6):679-91. Doi: 10.1111/bpa.1222
  25. Kalinowska M, Chávez AE, Lutzu S, Castillo PE, Bukauskas FF, Francesconi A. Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their Remodeling by Metabotropic Glutamate Receptors. J Biol Chem. 290(26):15909-20. Doi: 10.1074/jbc.M115.640136
  26. Krüger E. Mena W, Lahr EC, Johnson EC and Ewer J. (2015). Genetic analysis of Eclosion Hormone action during Drosophila larval ecdysis. Development, 142(24):4279-4287. Doi: 10.1242/dev.126995
  27. Langenhan T, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, Monk KR (2015) Model Organisms in GPCR Research. Mol Pharmacol. 88(3):596-603. Doi: 10.1124/mol.115.098764
  28. Leiva V, Tejo M, Guiraud P, Schmachtenberg OOrio P and Marmolejo-Ramos F.  Modeling neural activity with cumulative damage distributions. Biological Cybernetics. 109(4-5):421-33. Doi: 10.1007/s00422-015-0651-9
  29. López-Cabaña ZE, Valdés O, Vergara CE, Camarada MB, Nachtigall FM, Gonzalez-Nilo FD, Santos LS (2015) Photophysical Studies Of The Interactions Of Poly(amidoamine) Generation Zero (PAMAM G0) With Copper And Zinc Ions. Journal Of Luminescence 164:23-30. Doi: 10.1016/j.jlumin.2015.03.019
  30. Márquez-Miranda V, Camarada MB, Araya-Durán I, Varas-Concha I, Almonacid DE, Gonzalez-Nilo F. (2015) Biomimetics: From Bioinformatics to Rational Design of Dendrimers as Gene Carriers. PLoS One. 10(9):e0138392. Doi: 10.1371/journal.pone.013839
  31. Miño-Galaz GA.  (2015)  Allosteric Communication Pathways and Thermal Rectification in PDZ‑2 Protein: A Computational Study  J. Phys Chem B . 119(20):6179-89. Doi: 10.1021/acs.jpcb.5b02228
  32. Miño-Galaz GA, Gutierrez G (2015) Hydrogen bonds and asymmetrical heat diffusion in alpha helices. A computational analysis Chemical Physics Letters 635:16-2. Doi: 10.1021/acs.jpcb.5b02228
  33. Morales-Camilo N, Salas CO, Sanhueza C, Espinosa-Bustos C, Sepúlveda-Boza S, Reyes-Parada M, Gonzalez-Nilo F, Caroli Rezende M, Fierro A. (2014) Synthesis, biological evaluation and molecular simulation of chalcones and aurones as selective MAO-B inhibitors. Chem Biol Drug Des. 85(6):685-95 Doi: 10.1111/cbdd.12458
  34. Morera FJ, Baez-Nieto D, Lorenzo Y, Castillo K, Pupo A, Vargas-Chacoff L and Gonzalez C (2015) Role of ion channels in salt secretion by atlantic salmon gills during acclimation to seawater.  Physiological Mini Reviews, 8(1)
  35. Morera FJ, Saravia J, Pontigo JP, Vargas-Chacoff L, Contreras GF, Pupo A, Lorenzo Y, Castillo K, Tilegenova C, Cuello LG, Gonzalez C. (2015) Voltage-dependent BK and Hv1 channels expressed in non-excitable tissues: new therapeutics opportunities as targets in human diseases. Pharmacol Res. 101:56-64 Doi: 10.1016/j.phrs.2015.08.011
  36. Naranjo D, Wen H and Brehm P (2015). Zebrafish CaV2.1 Calcium Channels Are Tailored for Fast Synchronous Neuromuscular Transmission. Biophysical Journal 108(3):578-84. Doi: 10.1016/j.bpj.2014.11.3484
  37. Olivares E, Orio P. (2015) Mathematical Modeling of TRPM8 and the Cold Thermoreceptors. In: TRP Channels in Sensory Transduction. Madrid, R.; Bacigalupo, J.,editors. Springer International Publishing
  38. Olivares E, Salgado S, Maidana JP, Herrera G, Campos M, Madrid R and Orio P (2015). TRPM8-dependent dynamic response in a mathematical model of cold thermoreceptor. PLOS One 588(Pt 17):3141-8 Doi: 10.1371/journal.pone.0139314
  39. Orellana JA, Moraga-Amaro R, Díaz-Galarce R, Rojas S, Maturana CJ, Stehberg J, Sáez JC . (2015) Restraint stress increases hemichannel activity in hippocampal glial cells and neurons. Front Cell Neurosci. 9:102. Doi: 10.3389/fncel.2015.00102.
  40. Poblete H, Oyarzún I, Olivero P, Comer J, Zuñiga M, Sepulveda RV, Báez-Nieto D, Gonzalez Leon CGonzalez-Nilo FLatorre R. (2015) Molecular Determinants of Phosphatidylinositol 4,5Bisphosphate (PI(4,5)P2) Binding to Transient Receptor Potential V1 (TRPV1) Channels. J Biol Chem. 290(4):2086-98. Doi: 10.1074/jbc.M114.613620
  41. Prado-Gutierrez P, Castro-Fariñas A, Morgado-Rodriguez L, Velarde-Reyes E, Martinez AD, Martínez-Montes E.  (2015) Habituation of auditory steady state responses evoked by amplitude-modulated acoustic signals in rats. Audiology Research 5(113):21-28. Doi: 10.4081/audiores.2015.113
  42. Retamal MA, Leon-Paravic CG, Ezquer M, Ezquer F, Del Rio R, Pupo A, Martinez ADGonzalez C (2015) Carbon Monoxide: A New Player in the Redox Regulation of Connexin Hemichannels. IUBMB Life 67(6):428-37. Doi: 10.1002/iub.1388
  43. Retamal MA, Reyes EP, García IE, Pinto B, Martínez AD, González C (2015) Diseases associated with leaky hemichannels. Frontiers in Cellular Neuroscience. 9:267. Doi: 10.3389/fncel.2015.00267
  44. Riquelme MA, Cea LA, Vega JL, Puebla C, Vargas AA, Shoji KF, Subiabre M, Sáez JC. (2015) Pannexin channels mediate the acquisition of myogenic commitment in C2C12 reserve cells promoted by P2 receptor activation. Front Cell Dev Biol. 3:25. Doi: 10.3389/fcell.2015.00025
  45. Rivas-Aravena A, Fuentes Y, Cartagena J, Brito T, Poggio V, La Torre J, Mendoza H, Gonzalez-Nilo F, Sandino AM, Spencer E. (2015) Development of a nanoparticle-based oral vaccine for Atlantic salmon against ISAV using an alphavirus replicon as adjuvant. Fish Shellfish Immunol. 45(1): 157-166. Doi: 10.1016/j.fsi.2015.03.033
  46. Rovegno M, Soto PA, Sáez PJ, Naus CC, Sáez JC and von Bernhardi R. (2015)  Connexin43 hemichannels mediate secondary cellular damage spread from the trauma zone to distal zones in astrocyte monolayers. Glia 63(7):1185-99. Doi: 10.1002/glia.22808
  47. Sáez JC, Cisterna BA, Vargas A, Cardozo CP. (2015) Regulation of pannexin and connexin channels and their functional role in skeletal muscles. Cell Mol Life Sci. 72(15):2929-35. Doi: 10.1007/s00018-015-1968-1
  48. Salas D, Puebla C, Lampe PD, Lavandero S, Sáez JC. (2015) Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition. Biochim Biophys Acta. 1852(7):1268-1277. Doi: 10.1016/j.bbadis.2015.03.004
  49. Suzuki K, Lovera M, Schmachtenberg O and Couve E. (2015) Axonal Degeneration in Dental Pulp precedes Primary Teeth Exfoliation. J Dental Res. 94(10):1446-53. Doi: 10.1177/0022034515593055
  50. Talaverón R, Fernández P, Escamilla R, Pastor AM, Matarredona ER, Sáez JC (2015)  Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells. Front Cell Neurosci. 9:411. Doi: 10.3389/fncel.2015.00411
  51. Tindi JO, Chávez AE, Cvejic S, Calvo-Ochoa E, Castillo PE, Jordan BA. (2015) ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization. J Neurosci. 35(24):8986-96. Doi: 10.1523/JNEUROSCI.4029-14.2015.
  52. Valdés, J, Olivares J, Ponce D, and Schmachtenberg O (2015) Analysis of olfactory sensitivity in rainbow trout (Oncorhynchus mykiss) reveals their ability to detect lactic acid, pyruvic acid and four B-vitamins. Fish Physiol. Biochem., 41(4):879-85. Doi: 10.1007/s10695-015-0054-9
  53. Valdés O, Vergara CE, Camarada MB, Carrasco-Sánchez V, Nachtigall FM, Tapia J, Fischer R, González-Nilo FD, Santos LS. (2014) Synthesis and characterization of an insoluble polymer based on polyamidoamine: Applications for the decontamination of metals in aqueous systems. J Environ Manage. 147:321-9. Doi: 10.1016/j.jenvman.2014.09.021
  54. Whitlock KE. (2015) The loss of scents: Do defects in olfactory sensory neuron development underlie human disease? Birth Defects Res C Embryo Today. 105(2):114-25. Doi: 10.1002/bdrc.21094


  1. Abarca F, Gutierrez-Maldonado SE, Parada P, Martinez P, Maass A and Pérez-Acle T (2014) Insights on the structure and stability of Licanantase: a trimeric acid-stable coiled-coil lipoprotein from Acidithiobacillus thiooxidans. Peer J. 2:e457. Doi: 10.7717/peerj.457.
  2. Araya-Secchi R, Pérez-Acle T , Seung-gu Kang, Huynh T, Bernardin A, Escalona Y, Garate JAMartinez AD, García IE, Sáez JC and Zhou R (2014) Characterization of a Novel Water Pocket Inside the Human Cx26 Hemichannel Structure. Biophysical Journal, 107:599-612. Doi: 10.1016/j.bpj.2014.05.037
  3. Ardiles AO, Flores-Muñoz C, Toro-Ayala G, Cárdenas AM, Palacios AG, Muñoz P, Fuenzalida M, Sáez JCMartinez AD. (2014). Pannexin 1 regulates the bidirectional hippocampal synaptic plasticity in the adult mice. Front Cell Neurosci. 8:326. Doi: 10.3389/fncel.2014.00326.
  4. Arenas-Salinas M, Ortega-Salazar S, Gonzalez-Nilo FD, Pohl E, Holmes DS, Quatrini R. (2014) AFAL: a web service for profiling amino acids surrounding ligands in proteins. J Comput Aided Mol Des. 28(11):1069-76. Doi: 10.1007/s10822-014-9783-6.
  5. Arenas-Salinas M, Townsend PD, Brito C, Marquez V, Marabolli V, Gonzalez-Nilo F, Matias C, Watt RK, López-Castro JD, Domínguez-Vera J, Pohl E, Yévenes A. (2014) The crystal structure of ferritin from Chlorobium tepidum reveals a new conformation of the 4-fold channel for this protein family. Biochimie. 106:39-47 Doi: 10.1016/j.biochi.2014.07.019.
  6. Baez D, Raddatz N, Ferreira G, Gonzalez C, Latorre R.(2014) Gating of Thermally Activated Channels. In: Thermal Sensors. L. Islas and F. Qin. Eds. Current Topics in Membranes.  74:51-87. Doi: 10.1016/B978-0-12-800181-3.00003-8.
  7. Bhakat S, Martin AJ, Soliman ME. (2014) An integrated molecular dynamics, principal component analysis and residue interaction network approach reveals the impact of M184V mutation on HIV reverse transcriptase resistance to lamivudine. Mol Biosyst. 10(8):2215-28. Doi: 10.1039/c4mb00253a.
  8. Brito C, Matias C, Gonzalez-Nilo FD, Watt RK, Yévenes A. (2014) The C-Terminal Regions Have an Important Role in the Activity of the Ferroxidase Center and the Stability of Chlorobium tepidum Ferritin. Protein J. 33(3):211-20 Doi: 10.1007/s10930-014-9552-3.
  9. Cárdenas JP, Olivares G, Cabrera F, Alfaro R, Goya D, Samaniego H, Gibert J, Palacios AG. Redes complejas: un caso de estudio sobre la colaboración científica. En: Las Rutas de la complejidad. Edmundo Bustos A, Pablo A. Marquet, Adrián G. Palacios Editores. Ediciones Instituto de Sistemas Complejos de Valparaíso, Valparaiso, Chile, 211p
  10. Cea LA, Riquelme MA, Vargas AA, Urrutia C, Sáez JC,. (2014) Pannexin 1 channels in skeletal muscles.  Front Physiol. 5:139. Doi: 10.3389/fphys.2014.00139.
  11. Chang LYL, Lowe J, Ardiles A, Lim J, Grey AC, Robertson K, Danesh-Meyer H, Palacios AG, Acosta ML (2014). Alzheimer’s disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers. Alzheimer’s & Dementia. 10(2):251-261. Doi: 10.1016/j.jalz.2013.06.004.
  12. Cisterna BA, Cardozo C and Sáez JC (2014) Neuronal involvement in muscular atrophy. Front. Cell. Neurosci. 8:405. Doi: 10.3389/fncel.2014.00405
  13. Cornejo I, Andrini O, Niemeyer MI, Marabolí V, González-Nilo FD, Teulon J, Sepúlveda FV, Cid LP. (2014) Identification and Functional Expression of a Glutamate- and Avermectin-Gated Chloride Channel from Caligus rogercresseyi, a Southern Hemisphere Sea Louse Affecting Farmed Fish. PLoS Pathog. 10(9):e1004402. Doi: 10.1371/journal.ppat.1004402.
  14. Couve E, Osorio R, Schmachtenberg O (2014) Reactionary Dentinogenesis and Neuroimmune Response in Dental Caries. J Dent Res. 93(8):788-793. Doi: 10.1177/0022034514539507.
    Ewer J, Jindra M (2014). Development and regulation: Departing from paradigms.  Editorial overview: Curr. Op. Insect Sci. 1: vii-ix. Doi: 10.1016/j.cois.2014.05.006
  15. Figueroa VA, Retamal MA, Cea LA, Salas JD, Vargas AA, Verdugo CA, Jara O, Martinez AD and Sáez JC  (2014) Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells. Front. Cell. Neurosci. 8:265. Doi: 10.3389/fncel.2014.00265.
  16. Garate JAPérez-Acle T and Oostenbrink C (2014) On the thermodynamics of carbon nanotube single-file water loading: Free energy, Energy and Entropy calculations Phys. Chem. Chem. Phys. 16(11):5119-28. Doi: 10.1039/c3cp54554g.
  17. González-Jamett AM, Haro-Acuña V, Momboisse F, Caviedes P, Bevilacqua JA, Cárdenas AM. (2014) Dynamin-2 in nervous system disorders.  Journal of Neurochemistry. 128(2):210-23. Doi: 10.1111/jnc.12455.
  18. Gonzalo Hernández, Carlos Jaime Barrios Hernández, Gilberto Díaz, Carlos Garcia Garino, Sergio Nesmachnow, Tomas Perez-Acle, Mario Storti, Mariano Vasquez (Editors). High Performance Computing. Communications in Computer and Information Science. First HPCLATAM – CLCAR Latin American Conference CARLA 2014. Springer-Verlag Berlin Heidelberg 2014. ISBN 978-3-662-45482-4
  19. Jabba S, Goyal R, Sosa-Pagán JO, Moldenhauer H, Wu J, Kalmeta B, Bandell M, Latorre R, Patapoutian A, Grandl J. (2014)  Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six. Neuron. 82(5):1017-31. Doi: 10.1016/j.neuron.2014.04.016.
  20. Le HT, Sin WC, Lozinsky S, Bechberger J, Vega JL, Guo XQ, Sáez JC, Naus CC. (2014) Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress. J Biol Chem. 289(3):1345-54. Doi: 10.1074/jbc.M113.508390.
  21. Leiva A, Fuentes I, Bossel E, Urzua M, Mendez M, Pino M, Radic D, Márquez V, Gonzalez-Nilo FD (2014) Block Copolymers In The Synthesis Of Gold Nanoparticles. Two New Approaches: Copolymer Aggregates As Reductants And Stabilizers And Simultaneous Formation Of Copolymer Aggregates And Gold Nanoparticles. J Of Polymer Science, 2014. 52(21):3069–79. Doi:10.1002/pola.27354
  22. Martín P, Moncada M, Enrique N, Asuaje A, Valdez Capuccino JM, Gonzalez C, Milesi V.  (2014) Arachidonic acid activation of BKCa (Slo1) channels associated with the β 1 subunit in human vascular smooth muscle cells. Pflügers Archiv European Journal of Physiology 466(9):1779-92. Doi: 10.1007/s00424-013-1422-x.
  23. Miño G, Barriga R, Gutierrez G. (2014) Hydrogen Bonds And Heat Diffusion In Α-Helices: A Computational Study. The Journal Of Physical Chemistry B. 118(34):10025-34. Doi: 10.1021/jp503420e.
  24. Moldenhauer H, Latorre R Grandl J. (2014) The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-Methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole. PLoS One. 9(9):e106776. Doi: 10.1371/journal.pone.0106776.
  25. Momboisse F, Olivares MJ, Báez-Matus X, Guerra MJ, Flores-Muñoz C, Sáez JCMartinez AD , Cárdenas AM. (2014) Pannexin 1 channels: new actors in the regulation of catecholamine release from adrenal chromaffin cells. Front Cell Neurosci. 8:270. Doi: 10.3389/fncel.2014.00270.
  26. Monrás JP, Collao B, Molina-Quiroz RC, Pradenas GA, Saona LA, Durán-Toro V, Ordenes-Aenishanslins N, Venegas FA, Loyola DE, Bravo D, Calderón PF, Calderón IL, Vásquez CC, Chasteen TG, Lopez DA, Pérez-Donoso JM. (2014) Microarray analysis of the Escherichia coli response to CdTe-GSH Quantum Dots: understanding the bacterial toxicity of semiconductor nanoparticles. BMC Genomics, 15(1):1099. Doi: 10.1186/1471-2164-15-1099.
  27. Neely A, Hidalgo P. (2014) Structure-function Of Proteins Interacting With The Α1 Pore-forming Subunit Of High-voltage-activated Calcium Channels. Front Physiol. 5:209 Doi: 10.3389/fphys.2014.00209.
  28. Negrón-Oyarzo I, Pérez MA, Terreros G, Munoz P, Dagnino-Subiabre A. (2014) Effects of Chronic Stress in Adolescence on Learned Fear, Anxiety, and Synaptic Transmission in the rat Prelimbic Cortex. Behav Brain Res. 259:342-53. Doi: 10.1016/j.bbr.2013.11.001.
  29. Olivares MJ, González-Jamett AM, Guerra MJ, Baez-Matus X, Haro-Acuña V, Martínez-Quiles N, Cárdenas AM. (2014) Src Kinases Regulate De Novo Actin Polymerization during Exocytosis in Neuroendocrine Chromaffin Cells.  PLoS One. 2014 9(6):e99001. Doi: 10.1371/journal.pone.0099001.
  30. Orellana JA, Sáez JC, Bennett MV, Berman JW, Morgello S, Eugenin EA. (2014) HIV increased the release of dickkopf-1 (DKK1) protein from human astrocytes by a Cx43 hemichannel-dependent mechanism.  J Neurochem. 128(5):752-63 . Doi: 10.1111/jnc.12492.
  31. Palacios-Munoz A, Escobar MJ, Vielma A, Araya J, Astudillo A, Garcia I, Valdivia G, Hurtado J, Schmachtenberg OMartinez AD, Palacios AG (2014) Role Of Connexin Channels In The Retinal Light Response Of A Diurnal Rodent. Frontiers In Cellular Neuroscience. 8:249. Doi: 10.3389/fncel.2014.00249.
  32. Pantazis A, Savalli N, Sigg D, Neely A, Olcese R. (2014) Functional heterogeneity of the four voltage sensors of a human L-type calcium channel. Proc Natl Acad Sci U S A. 111(51):18381-6. Doi: 10.1073/pnas.1411127112
  33. Pezo D, Soudry D and Orio P (2014). Diffusion approximation-based simulation of stochastic ion channels: which method to use?. Front. Comput. Neurosci. 8:139. Doi: 10.3389/fncom.2014.00139.
  34. Pupo A, Báez-Nieto D, Martinez ALatorre R, Gonzalez C (2014) Proton Channel Models: Filling The Gap Between Experimental Data And The Structural Rationale. Channels (Austin). 8(3):180-192. Doi: 10.4161/chan.286658(3):180-192
  35. Pupo A, Gonzalez León C. (2014) In pursuit of an inhibitory drug for the proton channel. Proc Natl Acad Sci U S A. 111(27):9673-4. Doi: 10.1073/pnas.1408808111
  36. Raddatz N, Castillo JP, Gonzalez C , Alvarez O, Latorre R (2014) Temperature And Voltage Coupling To Channel Opening In Transient Receptor Potential Melastatin 8 (TRPM8). J Biol Chem. 289(51):35438-54 Doi: 10.1074/jbc.M114.612713.
  37. Retamal MA, Alcayaga J, Bultynck G, Leybaer L, Sáez PJ, Fernandez R, León LE and Sáez JC (2014) Opening of pannexin and connexin based-channels increases the excitability of nodose ganglion sensory neurons. Front. Cell. Neurosci. Front. Cell. Neurosci. 8:158. Doi: 10.3389/fncel.2014.00158.
  38. Retamal MA, Sáez JC . (2014) Hemichannels; from the molecule to the function. Front Physiol. 5:411. Doi: 10.3389/fphys.2014.00411.
  39. Retamal MJ, Cisternas MA, Gutierrez-Maldonado SE, Pérez-Acle T, Seifert B, Busch M, Huber P, Volkmann UG. (2014) Towards Bio-silicon Interfaces: Formation Of An Ultra-thin Self-hydrated Artificial Membrane Composed Of Dipalmitoylphosphatidylcholine (DPPC) And Chitosan Deposited In High Vacuum From The Gas-phase. J Chem Phys. 141(10):104201. Doi: 10.1063/1.4894224.
  40. Sáez JC, Leybaert L. (2014) Hunting for connexin hemichannels. FEBS Lett. 588(8):1205-1211. Doi: 10.1016/j.febslet.2014.03.004.
  41. Sáez PJ, Shoji KF, Aguirre A, Sáez JC. (2014) Regulation Of Hemichannels And Gap Junction Channels By Cytokines In Antigen-Presenting Cells. Mediators Inflamm. 2014:742734. Doi: 10.1155/2014/742734.
  42. Schramm OG, López-Cortés X, Santos LS, Laurie VF, Gonzalez-Nilo FD, Krolik M, Fischer R, Di Fiore S. (2014) pH-dependent nano-capturing of tartaric acid using dendrimers. Soft Matter. 10(4):600-8. Doi: 10.1039/c3sm52255e.
  43. Shoji KF, Sáez PJ, Harcha P, Aguila HL, Sáez JC. (2014) Pannexin1 channels act downstream of P2X 7 receptors in ATP-induced murine T-cell death.  Channels (Austin). 8(2):142-56.
  44. Torres-Paz J, Whitlock KE . (2014) The olfactory sensory system develops from coordinated movements within the neural plate. Dev Dyn. 243(12):1619-31. Doi: 10.1002/dvdy.24194.
  45. Torres YP, Granados ST, Latorre R (2014) . Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits. Frontier in Physiology. 5:383 Doi: 10.3389/fphys.2014.00383.
  46. Vielma AZ, Agurto A, Valdes J, Palacios AGSchmachtenberg O (2014) Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells. PLoS One, 9(12):e114330. Doi: 10.1371/journal.pone.0114330.
  47. White BH, Ewer J. (2014) Neural and Hormonal Control of Postecdysial Behaviors in Insects. Annu Rev Entomol. 59:363-81. Doi: 10.1146/annurev-ento-011613-162028
  48. Whitlock KE. (2014) Zebrafish Invade Valparaiso: Third Meeting and Symposium of the Latin American Zebrafish Network. Zebrafish. 11(6):580-582
  49. Whitlock, K.E. & Ciencia al Tiro, 2014, La alegria de la Ciencia, Andros Impresores, Santiago, Chile 118 p.


  1. Aguirre A, Maturana CJ, Harcha PA, Sáez JC. (2013) Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation. Mediators Inflamm. 2013:893521. Doi: 10.1155/2013/893521
  2. Aguirre A, Shoji KF, Saez JC, Henriquez M, Quest AFG. (2013) FasL-Triggered death of jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between fas and the purinergic receptor P2X7. Journal of Cellular Physiology 228 (2): 485–493. Doi: 10.1002/jcp.24159
  3. Almeyda Campos MV, Costa C, Gonzalez C, Latorre R, Milesi V, Ferreira G. 2013. New biomedical and physiological knowledge of the sport (with emphasis on ion channels in skeletal muscle). In “New Technologies and Innovation in Human Movement.” (Book VI REMH). Ed. Universidad de Chihuahua.
  4. Ardiles A, Ewer J, Acosta ML, Kirkwood A, Martinez A, Ebensperger  LA, Bozinovic  F,  Lee TM, Palacios AG. (2012). Octodon degus (Molina 1782): A model in comparative biology and biomedicine. Cold Spring Harbor Protocols. 2013(4): 312-18. Doi: 10.1101/pdb.emo071357
  5. Bazáes A, Olivares J, Schmachtenberg O. (2013) Properties, projections and tuning of teleost olfactory receptor neurons. Journal of Chemical Ecology. 39(4):451-64. Doi: 10.1007/s10886-013-0268-1
  6. Boric K, Orio P, Viéville T, Whitlock KE (2013). Quantitative analysis of cell migration using optical flow. PLOS One,8(7): e69574. Doi: 10.1371/journal.pone.0069574.
  7. Castillo K, Valenzuela V, Matus S, Nassif M, Oñate M, Fuentealba Y, Encina G, Irrazabal T, Parsons G, Court FA, Schneider BL, Armentano D, Hetz C. (2013) Measurement of autophagy flux in the nervous system in vivo. Cell Death Dis. 14;4:e917. Doi: 10.1038/cddis.2013.421
  8. Cea LA, Cisterna BA, Puebla C, Frank M, Figueroa XF, Cardozo C, Willecke K, Latorre R, Sáez JC. (2013) De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy. Proc Natl Acad Sci U S A. 110(40):16229-34. Doi: 10.1073/pnas.1312331110
  9. Cessac B and Palacios AG. (2013) Spike train statistics from empirical facts to theory: the case of the retina. In Mathematical Problems in Computational Biology and Biomedicine. Cazals F, Kornprobst P, Springer, pag. 261-302. Doi:10.1007/978-3-642-31208-3_8
  10. Contreras GF, Castillo K, Enrique N, Carrasquel-Ursulaez W, Castillo JP, Milesi V, Neely A, Alvarez O, Ferreira G, Gonzalez C, Latorre R. (2013) A BK (Slo1) channel journey from molecule to physiology. Channels (Austin). 7(6): 441-457. Doi: 10.4161/chan.26242
  11. Couve E, Osorio R and Schmachtenberg O. (2013) The Amazing Odontoblast: Activity, Autophagy and Aging. J Dental Res.92(9):765-72. Doi: 10.1177/0022034513495874
  12. Escobar MJ, Palacios AG. (2013). Beyond the retina neural coding: On Models and Neural Rehabilitation. Journal of Physiology Paris. 107(5):335-7. Doi: 10.1016/j.jphysparis.2013.08.002
  13. Escobar MJ, Pezo D, Orio P. (2013) Mathematical analysis and modeling of motion direction selectivity in the retina. Journal of Physiology Paris. 107(5):349-59. Doi: 10.1016/j.jphysparis.2013.08.003
  14. Figueroa XF, Lillo MA, Gaete PS, Riquelme M, Sáez JC. (2013) Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels. Neuropharmacology. 75: 471–478. Doi: 10.1016/j.neuropharm.2013.02.022
  15. Figueroa V, Sáez PJ, Salas JD, Salas D, Jara O, Martínez AD, Saez JC , Retamal MA. (2013) Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca(2+)-dependent pathway. Biochim Biophys Acta. 1828(3):1169-79 . Doi: 10.1016/j.bbamem.2012.12.006
  16. Giaume C, Froger N, Orellana JA, Retamal M and Sáez JC. (2013) Role of microglial activation in astroglial connexin expression and function leading to neurotoxicity”. Connexin cell communication channels: roles on the immune system and immunopathology (ed. Oviedo-Orta, Kwak and Evans). Taylor and Francis publisher. Pag 219-232.
  17. Giaume C, Leybaert L, C Naus C, Sáez JC. (2013) Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front Pharmacol. 2013;4:88. Doi: 10.3389/fphar.2013.00088
  18. Gonzalez, C, Rebolledo S, Perez M and Larsson HP. (2013) Molecular mechanism of voltage sensing in voltage-gated proton channels. Journal of General Physiology. 141(3):275-85. Doi: 10.1085/jgp.201210857
  19. Gonzalez-Jamett AM,  Momboisse F, Guerra MJ, Ory S, Baez-Matus X, Barraza N, Calco V, Houy S, Couve E, Neely A, Martínez A, Gasman S, Cárdenas AM (2013) Dynamin-2 regulates fusion pore expansion and quantal release through a mechanism that involves actin dynamics in neuroendocrine chromaffin cells. PLOS ONE, 8(8):70638.
  20. González-Jamett AM, Momboisse F, Haro-Acuña V, Bevilacqua JA, Caviedes P, Cárdenas AM. (2013) Dynamin-2 Function and Dysfunction Along the Secretory Pathway. Front Endocrinol (Lausanne). 2013 Sep 18;4:126. Doi: 10.3389/fendo.2013.00126.
  21. Gonzalez-Jamett AM,  Momboisse F, Guerra MJ, Ory S, Baez-Matus X, Barraza N, Calco V, Houy S, Couve E, Neely A, Martínez AD, Gasman S, Cárdenas AM (2013) Dynamin-2 regulates fusion pore expansion and quantal release through a mechanism that involves actin dynamics in neuroendocrine chromaffin cells. PLOS ONE, 8(8):70638. Doi: 10.1371/journal.pone.0070638
  22. Hernández-Salinas R, Vielma AZ, Arismendi MN, Boric MP, Sáez JC, Velarde V. (2013) Boldine Prevents Renal Alterations In Diabetic Rats. J Diabetes Res. 2013:593672. Doi: 10.1155/2013/593672
  23. Johnson RG, Sáez JC. (2013) We’ve Had Important Advances in the Connexin/Pannexin Field, Yet There Is Still Much to Do Neuropharmacology. 75: 467–470. Doi: 10.1016/j.neuropharm.2013.08.011
  24. Kozoriz MG, Lai S, Vega JL, Sáez JC, Sin WC, Bechberger JF, Naus CC. (2013) Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia. Neuropharmacology.75 (2013) 549-556. Doi: 10.1016/j.neuropharm.2013.05.003
  25. Latorre R. and Báez-Nieto, D. (2013) Ca2+ activation of K+ channels: RCK domains. In: Encyclopedia of Biophysics. Springer Verlag. Gordon C.K. Roberts, editor. DOI 10.1007/978-3-642-16712-6.
  26. Latorre R, Contreras G (2013) Keeping you healthy: BK channel activation by omega-3 fatty acids.  Journal of General Physiology. 142:347-350. Doi: 10.1085/jgp.201311100
  27. Latorre RGonzalez C, Rojas P. (2012) Signal-Transduction-Dependent Channels. Neuroscience in the 21st Century, Eugene Martin and Donald Pfaff, eds. Springer. 81-107. Doi: 10.1007/978-1-4614-1997-6_5
  28. Latorre R, Morera FJ, Zaelzer C.  (2013). Voltage-dependent K+ channels. In: Encyclopedia of Biological Chemistry. 2nd Edition. Lane, M.D and  W.J. Lennarz, editors. Elsevier. Vol 1, pp. 399-404.
    Ocampo-Garcés A, Hernandez F, Palacios AG. (2013). REM sleep phase preference in the crepuscular Octodon degus assessed by selective REM sleep deprivation. Sleep. 36(8):1247-56. Doi: 10.5665/sleep.2896
  29. Orellana JA, Martinez AD, Retamal MA. (2013) Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules. Neuropharmacology. 75: 567–582
  30. Orellana JA, Velasquez S, Williams DW, Sáez JC, Berman JW, Eugenin EA. (2013) Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes. J Leukoc Biol. 94(3):399-407. Doi: 10.1189/jlb.0512249
  31. Osorio R, Schmachtenberg O (2013) Calcium-activated chloride channels do not contribute to the odorant transduction current in the marine teleost Isacia conceptionis. Journal of Fish Biology. 83 (5):1468-73. Doi: 10.1111/jfb.12253.
  32. Palacios AG, Lee TM. (2012). Husbandry and Breeding in the Octodon degus (Molina 1782).  Cold Spring Harbor Protocols. 2013(4): 350-53. Doi: 10.1101/pdb.prot073577
    Pastor P, Cisternas P, Salazar K, Silva-Alvarez C, Oyarce K, Jara N, Espinoza F, Martínez AD and Nualart F (2013) SVCT2 vitamin C transporter expression in progenitor cells of the postnatal neurogenic niche. Frontiers in Cellular Neuroscience. 7:119. Doi: 10.3389/fncel.2013.00119
  33. Qiu F, Rebolledo S, Gonzalez C, Larsson HP. (2013) Subunit Interactions during Cooperative Opening of Voltage-Gated Proton Channels. Neuron. 77(2), 288–98. Doi: 10.1016/j.neuron.2012.12.021.
  34. Ravanal MC, Alegría-Arcos M, Gonzalez-Nilo FD, Eyzaguirre J. (2013) Penicillium purpurogenum produces two GH family 43 enzymes with ß-xylosidase activity, one monofunctional and the other bifunctional: biochemical and structural analyses explain the difference. Arch Biochem Biophys. 540(1-2):117-2. Doi: 10.1016/
  35. Riquelme MA, Cea LA, Vega JL, Boric MP, Monyer H, Bennett MV, Frank M, Willecke K, Sáez JC. (2013) The ATP Required for Potentiation of Skeletal Muscle Contraction is released via Pannexin Hemichannels. Neuropharmacology. 75:594–603. Doi: 10.1016/j.neuropharm.2013.03.022.
  36. Sáez PJ, Orellana JA, Vega-Riveros N, Figueroa VA, Hernández DE, Castro JF, Klein AD, Jiang JX, Zanlungo S, Sáez JC. (2013) Disruption in connexin-based communication is associated with intracellular ca(2+) signal alterations in astrocytes from niemann-pick type C mice. PLoS One. 8(8):e71361. Doi: 10.1371/journal.pone.0071361
  37. Sáez PJ, Shoji KF, Retamal MA, Harcha PA, Ramírez G, Jiang JX, von Bernhardi R, Sáez JC. (2013) ATP is required and advances cytokine-induced gap junction formation in microglia in vitro. Mediators Inflamm. 2013:216402. Doi: 10.1155/2013/216402
  38. Sáez PJ, Shoji KF, Sáez JC. (2013) Gap Junctions in Antigen-Presenting Cells. In Connexin cell communication channels: roles on the immune system and immunopathology (ed. Oviedo-Orta, Kwak and Evans). Taylor and Francis publisher. pag 61-88. DOI: 10.1201/b14166-14
  39. Soto-Liebe K, López-Cortés XA, Fuentes-Valdes JJ, Stucken K, Gonzalez-Nilo F, Vásquez M. (2013) In silico analysis of putative paralytic shellfish poisoning toxins export proteins in cyanobacteria. PLoS One. 8(2):e55664. Doi: 10.1371/journal.pone.0055664.
  40. Tricarico D, Mele A, Calzolaro S, Cannone G,  Camerino MG, Dinardo MM, Latorre R, Conte Camerino D. (2013) Emerging Role of Calcium-Activated Potassium Channel in the Regulation of Cell Viability Following  Potassium Ions Challenge in HEK293 Cells and Pharmacological Modulation. Plos One. 8(7). e69551. Doi: 10.1371/journal.pone.0069551
  41. Vega JL, Subiabre M, Figueroa F, Schalper KA, Osorio L, González J, Sáez JC. (2013) Role of Gap Junctions and Hemichannels in Parasitic Infections. Biomed Res Int. 2013:589130. Doi: 10.1155/2013/589130
  42. Vega-Zuniga T, Medina FS, Fredes F, Zuniga C, Severín D, Palacios AG, Karten HJ, Mpodozis J. (2013). Does nocturnality drive binocular vision? Octodontine rodents as a case study. PlosOne. 8(12):e84199. Doi: 10.1371/journal.pone.0084199
  43. Vergara-Jaque AP, Comer JR, Monsalve LF, Gonzalez-Nilo FD, Sandoval C. (2013) Computationally Efficient Methodology for Atomic-Level Characterization of Dendrimer-Drug Complexes: A Comparison of Amine- and Acetyl-Terminated PAMAM. Journal of Physical Chemistry B. 117(22):6801-13. Doi: 10.1021/jp4000363
  44. Vilos C, Morales FA, Solar PA, Herrera NS, Gonzalez-Nilo FD, Aguayo DA, Mendoza HL, Comer J, Bravo ML, Gonzalez PA, Kato S, Cuello MA, Alonso C, Bravo EJ, Bustamante EI, Owen GI, Velasquez LA. (2013) Paclitaxel-PHBV nanoparticles and their toxicity to endometrial and primary ovarian cancer cells. Biomaterials. 34(16):4098-108. Doi: 10.1016/j.biomaterials.2013.02.034
  45. Yang S, Megill A, Ardiles AO, Ransom S, Tran T, Koh MT, Lee HK, Gallagher M, Kirkwood A (2013) Integrity Of MGluR-LTD In The Associative/commissural Inputs To CA3 Correlates With Successful Aging In Rats. J Neurosci.33(31):12670-8. Doi: 10.1523/JNEUROSCI.1086-13.2013


  1. Acuña MA, Pérez-Nuñez R, Noriega J, Cárdenas AM, Bacigalupo J, Delgado R, Arriagada C, Segura-Aguilar J, Caviedes R, Caviedes P. (2012) Altered voltage dependent calcium currents in a neuronal cell line derived from the cerebral cortex of a trisomy 16 fetal mouse, an animal model of down syndrome. Neurotoxicity Research. 22(1):59-68.
  2. Aguayo D, Gonzalez-Nilo F, Chipot C. (2012) Insight into the properties of cardiolipin containing bilayers from molecular dynamics simulations, using a hybrid all-atom/united-atom force field. Journal of Chemical Theory and Computation. 8(5):1765-1773.
  3. Ardiles AO, Tapia-Rojas CC, Mandal M, Alexandre F, Kirkwood A, Inestrosa NC & Palacios AG. (2012) Post-synaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer’s disease. Proceedings of the National Academy of Science. 109(34):13835-40 .
  4. Avila-Salas, F ; Sandoval, C ; Caballero, J ; Guinez-Molinos, S ; Santos, LS ; Cachau, RE ; Gonzalez-Nilo, FD (2012) Study of Interaction Energies between the PAMAM Dendrimer and Nonsteroidal Anti-Inflammatory Drug Using a Distributed Computational Strategy and Experimental Analysis by ESI-MS/MS JOURNAL OF PHYSICAL CHEMISTRY B 116 (7):2031-2039 DOI: 10.1021/jp2069122 
  5. Bazáes A. and Schmachtenberg O. (2012) Odorant tuning of olfactory crypt cells from juvenile and adult rainbow trout. Journal of Experimental Biology. 215(Pt 10):1740-8.
    Bennett MV, Garré JM, Orellana JA, Bukauskas FF, Nedergaard M, Sáez JC. (2012) Connexin and pannexin hemichannels in inflammatory responses of glia and neurons. Brain Research. 1487:3-15.
  6. Braidy N, Munoz P, Palacios AG, Castellano-González G, Inestrosa NC, Chung RS, Sachdev P, Guillemin GJ. (2012) Recent animal models for Alzheimer’s diseases: Clinical implications and basic research. Journal of Neural Transmission. 119(2):173-195.
  7. Cárdenas AM, Ardiles AO, Barraza N, Baéz-Matus X, Caviedes P. (2013) Role of Tau Protein in Neuronal Damage in Alzheimer’s Disease and Down Syndrome. Archives of Medical Research.43(8):645-54.
  8. Cea LA, Riquelme MA, Cisterna BA, Puebla C, Vega JL, Rovegno M, Sáez JC. (2012) Connexin- and  annexin-based channels in normal skeletal muscles and their possible role in muscle atrophy. Journal of Membrane  Biology. 245(8):423-36. 
  9. Contreras GF, Neely A, Alvarez O, Gonzalez C, Latorre R. (2012) Modulation of BK channel voltage gating by different auxiliary β subunits. Proceedings of the National Academy of Sciences. 109(46):18991-6
  10. Cortés C, Eugenin E, Aliaga E, Carreño LJ, Bueno SM, Gonzalez PA, Gayol S, Naranjo D, Noches V, Marassi MP, Rosenthal D, Jadue C, Ibarra P, Keitel C, Wohllk N, Court F, Kalergis AM, Riedel CA. (2012) Hypothyroidism in the adult rat causes incremental changes in brain-derived neurotrophic factor, neuronal and astrocyte apoptosis, gliosis, and deterioration of postsynaptic density. Thyroid. 22(9):951-63.
  11. Couve, E., Osorio, O. and Schmachtenberg, O. (2012) Mitochondrial autophagy and lipofuscin accumulation in aging odontoblasts. Journal of Dental Research. 91(7): 1-6.
    Dinardo MM, Camerino G, Mele A, Latorre R., Conte Camerino D, Tricarico D. (2012) Splicing of the rSlo gene affects the molecular composition and drug response of Ca2+-activated K+ channels in skeletal muscle. Plos One, 7(7):e40235
  12. Eugenin EA, Basilio D, Sáez JC, Orellana JA, Raine CS, Bukauskas F, Bennett MV, Berman JW. (2012) The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. Journal of Neuroimmune Pharmacology. 7(3):499-518.
  13. Fiori MC, Figueroa V, Zoghbi ME, Saez JC, Reuss L, Altenberg GA.(2012) Permeation of calcium through purified connexin 26 hemichannels. Journal of  Biological Chemistry. 87(48): 40826-34
  14. Giaume C, Orellana JA, Abudara V, Sáez JC. (2012) Connexin-based channels in astrocytes: how to study their properties. Methods in Molecular Biology. 814:283-303.
  15. Gonzalez C, Báez-Nieto D, Valencia I, Oyarzún I, Rojas P, Naranjo D, and Latorre, R. (2012) K channels: function-structural overview. Comprehensive Physiology. 2: 2087-2149.
  16. Gonzalez C, Contreras G, Peysler A, Larsson P, Neely A, Latorre R. (2012) Voltage sensor of ion channels and enzymes. Biophysical Reviews. 4(1): 1-15.
  17. Gonzalez W, Riedelsberger J, Morales-Navarro SE, Caballero J, Alzate-Morales JH, González-Nilo FD, Dreyer I. (2012) The ph-sensor of the plant K+ uptake channel Kat1 is built of a sensory cloud rather than of single key amino acids. Biochemical Journal. 442(1):57-63. 
  18. Harden MV, Pereiro L, Ramialison M, Wittbrodt J, Prasad MK, McCallion AS, Whitlock KE. (2012) Close association of olfactory placode precursors and cranial neural crest cells does not predestine cell mixing. Developmental Dynamics. 241(7):1143-54.
  19. Huang S, Treviño M, He K, Ardiles A, Di Pasquale R, Guo Y, Palacios A, Huganir R, Kirkwood A. (2012) Pull-push neuromodulation of ltp and ltd enables bidirectional experience-induced synaptic scaling in visual cortex. Neuron. 73(3):497-510.
  20. Jara O, Acuña R, García IE, Maripillán J, Figueroa V, Sáez JC, Araya-Secchi R, Lagos CF, Pérez-Acle T, Berthoud VM, Beyer EC, Martínez AD. (2012) Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function. Molecular Biology of the Cell. 23(17):3299-3311.
  21. Koulakoff A, Mei X, Orellana JA, Sáez JC, Giaume C. (2012) Glial connexin expression and function in the context of Alzheimer’s disease. Biochimica et Biophysica Acta. 1818(8):2048-2057.
  22. Lagos CF, Araya-Secchi R, Thomas P, Pérez-Acle T, Tapia RA, Salas CO. (2012) Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione. Journal of Molecular Modeling. 18(5):2055-64. 
  23. Lahr EC, Dean D, Ewer J. (2012) Genetic analysis of ecdysis behavior in Drosophila reveals partially overlapping functions of two unrelated neuropeptides. Journal of Neuroscience. 32(20):6819-29.
  24. Maojo V, Fritts M, Martin-Sanchez F, De la Iglesia D, Cachau RE, Garcia-Remesal M, Crespo J, Mitchell JA, Anguita A, Baker N, Barreiro JM, Benitez SE, De la Calle G, Facelli JC, Ghazal P, Geissbuhler A, Gonzalez-Nilo F, Graf N, Grangeat P, Hermosilla I, Hussein R, Kern J, Koch S, Legre Y, Lopez-Alonso V, Lopez-Campos G, Milanesi L, Moustakis V, Munteanu C, Otero P, Pazos A, Perez-Rey D, Potamias G, Sanz F, Kulikowski C. (2012) Nanoinformatics: developing new computing applications for nanomedicine. Comput Sci Eng. 94(6):521-539. 
  25. Miranda-Laferte E, Schmidt S, Jara AC, Neely A, Hidalgo P. (2012) A short polybasic segment between the two conserved domains of the β2a-subunit modulates the rate of inactivation of R-type calcium channel. The Journal of Biological Chemistry.287(39):32588-97.
  26. Morera FJ, Alioua A, Kundu P, Salazar M, Gonzalez, C, Martinez AD, Stefani E, Toro L, Latorre R. (2012). The first transmembrane domain (TM1) of β2-subunit binds to the transmembrane domain S1 of α-subunit in BK potassium channels. FEBS Letters. 586(16):2287-93.
  27. Moscoso C, Vergara-Jaque A, Márquez-Miranda V, Sepúlveda R, Valencia I, Díaz-Franulic I, González-Nilo F, Naranjo D. (2012) K+ Conduction and Mg2+ Blockade in a Shaker Kv-Channel Single Point Mutant with an Unusually High Conductance.  Biophysical Journal, 103(6):1198-1207.
  28. Muñoz P (2012) Iron-mediated redox modulation in neural plasticity. Communicative & Integrative Biology 5:2,166–168.
  29. Muñoz P and Humeres A. (2012) Iron deficiency on neuronal function. Biometals 25:825–835.
  30. Nunez F, Ravello C, Urbina H, Perez-Acle T. (2012) A Rule-based Model of a Hypothetical Zombie Outbreak: Insights on the role of emotional factors during behavioral adaptation of an artificial population. arXiv:1210.4469v1 [q-bio.PE]
  31. Orellana JA, Sáez PJ, Cortés-Campos C, Elizondo RJ, Shoji KF, Contreras-Duarte S, Figueroa V, Velarde V, Jiang JX, Nualart F, Sáez JC, García MA. (2012) Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels. Glia. 60(1):53-68. 
  32. Orellana JA, Sánchez HA, Schalper KA, Figueroa V, Sáez JC. (2012) Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels. Advances in Experimental Medicine and Biology.740:777-794.
  33. Orellana JA, von Bernhardi R, Giaume C, and Sáez JC. (2012) Glial hemichannels and their involvement in aging and neurodegenerative diaseases. Reviews in Neuroscience. 23(2): 163–177.
  34. Orio P, Parra A, Madrid R, González O, Belmonte C, Viana F. (2012) Role Of Ih In The Firing Pattern Of Mammalian Cold Thermoreceptor Endings. J Neurophysiol. 108(11):3009-23. Doi: 10.1152/jn.01033.2011
  35. Orio P, Soudry D. (2012) Simple, fast and accurate implementation of the diffusion approximation algorithm for stochastic ion channels with multiple states. PLoS ONE. 7(5): e36670 
  36. Perez-Armendariz EM, Cruz-Miguel L, Coronel-Cruz C, Esparza-Aguilar M, Pinzon-Estrada E, Rancano-Camacho E, Zacarias-Climaco G, Olivares PF, Espinosa AM, Becke, I, Saez JC, Berumen J, Perez-Palacios G. (2012) Connexin 36 is expressed in beta and connexins 26 and 32 in acinar cells at the end of the secondary transition of mouse pancreatic development and increase during fetal and perinatal life. Anatomical Record-Advances In Integrative Anatomy And Evolutionary Biology. 295(6): 980-990 .
  37. Pertusa M, Moldenhauer H, Brauchi S, Latorre R, Madrid R, Orio P (2012). Mutagenesis and temperature-sensitive little machines. In: Mutagenesis, Mishra, R. Ed., InTech Open Access publisher. Chapter 11, pp 221-246.
  38. Rovegno M, Soto PA, Sáez JC, von Bernhardi R. (2012) Biological mechanisms involved in the spread of traumatic brain damage. Med Intensiva. 36(1):37-44.
  39. Schalper KA, Riquelme MA, Brañes MC, Martínez AD, Vega JL, Berthoud VM, Bennett MV, Sáez JC. (2012) Modulation of gap junction channels and hemichannels by growth factors. Molecular BioSystems. 8(3): 685-698.
  40. Stehberg J, Moraga-Amaro R, Salazar C, Becerra A, Echeverría C, Orellana JA, Bultynck G, Ponsaerts R, Leybaert L, Simon F, Sáez JC, Retamal MA. (2012) Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB Journal. 26(9):3649-57
  41. Stephenson JF, Partridge JC, Whitlock KE. (2012) Food and conspecific chemical cues modify visual behavior of zebrafish, danio rerio. Zebrafish. 9:68-73.
  42. Sundram V, Fanny S, Ng FS, Roberts MA, Millán C, Ewer J, Jackson FR. (2012) Requirements for LARK in the Drosophila circadian system. Journal of Biological Rhythms. 27(3):183-95.
  43. Vasquez JC, Palacios AG, Marre O, Berry II MJ, Cessac B (2012). Gibbs distribution analysis of temporal correlation structure on multicell spike trains from retina ganglions cells. Journal of Physiology Paris. 106(3-4):120-7 .
  44. Vergara-Jaque A, Poblete H, Lee EH, Schulten K, Gonzalez-Nilo FD, Chipot CJ. (2012) Molecular basis of drug resistance in A/H1N1 virus. Journal of Chemical Information and Modeling. 52(10):2650-6.
  45. Vielma AH, Retamal M, Schmachtenberg O. (2012) Nitric oxide signaling in the retina: What have we learned in two decades?. Brain Research. 430:112-25.


  1. Baez-Nieto, D., Castillo, JP., Dragicevic, C., Alvarez, O. and Latorre, R. (2011) Thermo-TRP channels: Biophysics of polymodal receptors. Adv. Exp. Med. Biol. 704:469-490
  2. Brauchi S., Orio P. (2011) Voltage Sensing in ThermoTRP Channels. Adv.Exp. Med. Biol. 704:517-530.
  3. Castillo JP, De Giorgis D, Basilio D, Gadsby DC, Rosenthal JJ, Latorre R, Holmgren M, Bezanilla F. (2011) Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid. Proc Natl Acad Sci U S A. 108:20556-20561
  4. Couve, E. and Schmachtenberg, O. (2011) Autophagic Activity and Aging in Human Odontoblasts. J Dental Res, 90(4): 523-8.
  5. Delgado, L.M. and Schmachtenberg, O. (2011) Neurogenesis in the adult goldfish cerebellum. Anat Rec 294: 11-15.
  6. Gonzalez C, Lopez Rogriguez A, Srikumar D, Rosenthal J & Holmgren M (2011) Editing of human KV1.1 channel mRNAs disrupts binding of the N-terminus tip at the intracellular cavity. Nature Commun. Aug 16;2:436. doi: 10.1038/ncomms1446 
  7. Gonzalez C*, Manzanares D*, Ivonnet P, Chen RS, Valencia-Gattas M, Conner G.E, Larsson HP, & Salathe M *Contributed equally.(2011) Functional apical BK channels are required for maintenance of airway surface liquid volume. J. Biol. Chem. 286(22):19830-9. 
  8. Grbic M, Van Leeuwen T, Clark RM, Rombauts S, Rouzé P, Grbic V, Osborne EJ, Dermauw W, Ngoc PC, Ortego F, Hernández-Crespo P, Diaz I, Martinez M, Navajas M, Sucena É, Magalhães S, Nagy L, Pace RM, Djuranovic S, Smagghe G, Iga M, Christiaens O, Veenstra JA, Ewer J, Mancilla R, Villalobos RM, Hutter JL, Hudson SD, Velez M, Yi SV, Zeng J, Pires-daSilva A, Roch F, Cazaux M, Navarro M, Zhurov V, Acevedo G, Bjelica A, Fawcett JA, Bonnet E, Martens C, Baele G, Wissler L, Sanchez-Rodriguez A, Tirry L, Blais C, Demeestere K, Henz SR, Gregory TR, Mathieu J, Verdon L, Farinelli L, Schmutz J, Lindquist E, Feyereisen R, Van de Peer Y. (2011) The genome of Tetranychus urticae reveals herbivorous pest adaptations. Nature. 479(7374):487-92. doi: 10.1038/nature10640.
  9. Latorre R, Brauchi S, Madrid R, Orio P. (2011) A cool channel in cold transduction. Physiology (Bethesda). Aug;26(4):273-85
  10. Martínez AD, Maripillán J, Acuña R, Minogue PJ, Berthoud VM, Beyer EC (2011) Different domains are critical for oligomerization compatibility of different connexins Biochemical Journal 436: 35-43
  11. Miranda-Laferte, E,Gonzalez-Gutierrez, G, Schmidt, S ,Zeug, A, Ponimaskin, EG, Neely, A, Hidalgo, P (2011) Homodimerization of the Src Homology 3 Domain of the Calcium Channel beta-Subunit Drives Dynamin-dependent Endocytosis JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 286(25): 22203-22210
  12. Muñoz P, Humeres A., Elgueta C., Kirkwood A., Hidalgo C. and Núñez M.T. (2011) Iron Mediates N-Methyl-D-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity. J. Biol. Chem. 286, (15): 13382-13392.
  13. Palacios AG, Cosmelli D, Cohen-Varela A. (2011). Un recorrido junto a Francisco Varela. Pag. 11-22. Edit. Adrian Palacios y Amy Cohen-Varela. La ciencia del ser: Las rutas de Francisco Varela. Editorial Universidad de Valparaiso. 320 p.
  14. Paul TA, Rovnak J, Quackenbush SL, Whitlock KE, Zhan H, Gong Z, Spitsbergen J, Paul R, Bowser PR, Casey JW. (2010). Transgenic expression of Walleye Dermal Sarcoma accessory genes in zebrafish does not result in tissue proliferation. Marine Biotechnology (NY). 13(2):142-50.
  15. Stephenson Jessica F.; Whitlock Kathleen E.; Partridge Julian C. (2011) Zebrafish Preference for Light or Dark Is Dependent on Ambient Light Levels and Olfactory Stimulation Zebrafish 8 (1): 17-22.
  16. Marcelo Salazar, Hans Moldenhauer and David Baez-Nieto. (2011) Could an Allosteric Gating Model Explain the Role of TRPA1 in Cold Hypersensitivity?. (Journal Club) The Journal of Neuroscience. 31(15):5554-5556 
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