Associate professor, Centro Interdisciplinario de Neurociencia de Valparaíso,
Facultad de Ciencias, Universidad de Valparaíso
Instructor, Department of Neuroscience, Albert Einstein College of Medicine, NY. USA (2013-2015).
MSc and Ph.D. in Biological Sciences, Neuroscience, Universidad de Valparaíso, Chile.
Pasaje Harrington 287, Playa Ancha. Valparaíso
All our behaviors and feelings, memories and thoughts rely on the interaction between neurons via synapses. Information transfer at the synapse, called synaptic transmission, is critical for proper brain function. Neuromodulatory systems play an important role in regulating synaptic function and plasticity, and dysregulation of these mechanisms underlies several neurological disorders and pathological conditions. While synaptic factors that tune excitatory and inhibitory synapses vary widely over neuronal circuitries, the relative importance of these factors in determining brain activity is not well understood.
The main interest of my lab is to understand the cellular and molecular events by which endogenous neuromodulators tune synaptic transmission and plasticity at excitatory and inhibitory synapses. To this end, we investigate how different neuromodulatory systems (e.g. endocannabinoids, opioids, serotonin, and dopamine) regulate synaptic function by studying the biophysical and physiological properties of individual synapses within different neuronal circuits. In particular, we focus on the retinal circuitry, where modulation of synaptic function will have profound influence on how we see the external world. In addition, we examine the hippocampus and prefrontal cortex, where modulation of synaptic transmission affects higher cognitive processes such as learning and memory. We use a combination of tools including electrophysiology, optogenetics, in vivo knock-down strategies, and cellular biology approaches to understand: (1) the functional role of endocannabinoid signaling in retinal synaptic function; and (2) how serotonin and opioid receptors modulate excitatory and inhibitory synapses to regulate behavior. By studying the mechanisms underlying neuronal communication and its regulation by neuromodulators, we expect to uncover important principles of nervous system function at the cellular level, allowing us to integrate this information into a larger framework from which to investigate aspects of retinal disorders as well as neuropsychiatric disorders.
- Delgado-Acevedo C, Estay SF, Radke AR, Sengupta A, Escobar AP, Henríquez-Belmar F, Reyes CA, Haro-Acuña V, Utreras E, Sotomayor-Zárate R, Cho A, Wendland JR, Kulkarni AB, Holmes A, Murphy DL, Chávez AE, Moya PR. 2018. Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression. Neuropsychopharmacology. 2018 Dec 26. doi: 10.1038/s41386-018-0302-7.
- Espinosa N, Alonso A, Morales C, Espinosa P, Chávez AE, Fuentealba P. 2019. Basal Forebrain Gating by Somatostatin Neurons Drives Prefrontal Cortical Activity. Cereb Cortex. 2019 Jan 1;29(1):42-53. doi: 10.1093/cercor/bhx302.
- Hashimotodani Y, Nasrallah K, Jensen KR, Chávez AE, Carrera D, Castillo PE. 2017. LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron. 2017 Aug 16;95(4):928-943.e3. doi: 10.1016/j.neuron.2017.07.028.
- Tindi JO, Chávez AE, Cvejic S, Calvo-Ochoa E, Castillo PE, Jordan BA. (2015) ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization. J Neurosci. 2015 Jun 17;35(24):8986-96.
- Chávez A.E*, Hernandez VM, Rodenas-Ruano A, Chan CS, Castillo PE* (2014). Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus. J. Neurosci. 10;34(50):16621-9 *Corresponding author
Our lab has close collaboration with the other members of the Circuits and Systems Neuroscience group at the CINV and with Drs. Pablo Moya (UV), Marco Fuenzalida (UV) and Gloria Arriagada (UNAB), with whom we aim to elucidate the mechanism underlying modulation of synaptic function in different neuronal circuits implicated in mood and anxiety disorders. Our lab also has strong collaboration with outstanding international scientists (e.g. Jeff Diamond, Pablo Castillo, and Yuki Hashimotodani).