[vc_row css=”.vc_custom_1517921741410{padding-right: 70px !important;padding-left: 70px !important;background-color: #ffffff !important;}”][vc_column 0=””][vc_single_image image=”22468″ img_size=”1240×300″ alignment=”center”][stm_title title_tag=”h4″ title=”Line 5: Computational biology and molecular simulation.”][\/stm_title][stm_btn_simple btn_style=”custom” btn_color=”blue” btn_alignment=”right” btn_link=”url:https%3A%2F%2Fcinv.uv.cl%2Fen%2Fresearchlines%2F|||” btn_link_text=”Back to Research Lines”][vc_column_text]<\/p>\n
[\/vc_column_text][vc_tta_tabs style=”flat” shape=”square” color=”blue” spacing=”” alignment=”center” active_section=”1″ no_fill_content_area=”true”][vc_tta_section title=”DESCRIPTION” tab_id=”description”][vc_column_text]<\/p>\n
Researchers working on Line 5 study intercellular communication processes, ion channel activation, neural dynamics, and neural networks through a combination of modeling and experimentation. Among other achievements, this has allowed them to determine the structure-function relationships for potassium channels and for other channels such as the pain and temperature sensors TRPV1, TRPM8 and TRPV4. Simulations of neuronal excitability allowed us to mathematically interpret the contribution of the TRPM8 channel to the sensation of cold. Using large-scale molecular simulations, the researchers have contributed to the understanding of how pore dimensions in the cell membrane determine ion transport in potassium channels. Large-scale brain dynamics simulations, using real data from the human connectome, have advanced the understanding of the effect of neuromodulators in the brain. Techniques used by these researchers include advanced mathematical and computational simulation methods..<\/p>\n
[\/vc_column_text][\/vc_tta_section][vc_tta_section title=”TEAM” tab_id=”team”][vc_toggle title=”Researchers.”]Danilo Gonz\u00e1lez \/ fono: (56) 2 2770 3606\u00a0\/ fernando.gonzalez@unab.cl
\nPatricio Orio\u00a0\/ fono:(56) 32 2995538 \/ patricio.orio@uv.cl
\nWael El-Deredy \/ fono: (56) 2508040 \/ wael.el-deredy@uv.cl[\/vc_toggle][vc_toggle title=”Associate Researchers.”]Yorley Duarte \/ CBIB-UNAB \/ yorley.duarte@unab.cl[\/vc_toggle][vc_toggle title=”Postdoctoral Researchers.”]Felipe Torres \/ felipe.torrese@sansano.usm.cl
\nGrace Whitaker \/ grace.whitaker@uv.cl[\/vc_toggle][vc_toggle title=”PhD Students.”]Andre G\u00f3mez \/ andre.gomez@uv.cl
\nDavid Araya \/ daraya78@gmail.com
\nDiego Becerra \/ diego.becerraq@postgrado.uv.cl
\nFernando Lehue \/ fernando.lehue@postgrado.uv.cl
\nGabriela Vargas \/ givargas@uc.cl
\nHern\u00e1n Hern\u00e1ndez \/ hernandezlarzabal@gmail.com
\nJavier Palma \/ javier.palma@cinv.cl
\nLiset Gonz\u00e1lez \/ llisetgr90@gmail.com
\nMelissa Alegria \u00a0\/ fono: (56) 2 27703405 \/ ibi.malegria@gmail.com
\nPamela Illescas \/ pamela.illescas@postgrado.uv.cl
\nRomina Sep\u00falveda \/ fono: (56) 2 27703405 \/ rosepulveda87@gmail.com
\nSebasti\u00e1n Espinoza \/ seabstian.espinoza@uv.cl
\nSebasti\u00e1n Orellana \/ sebastian.orellana@postgrado.uv.cl
\nYunier Prieur \/ yunier.prieur@postgrado.uv.cl[\/vc_toggle][\/vc_tta_section][vc_tta_section title=”FEATURED PUBLICATIONS” tab_id=”publications”][vc_row_inner 0=””][vc_column_inner 0=””][vc_column_text]<\/p>\n
[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][vc_tta_section title=”PROJECTS” tab_id=”projects”][vc_column_text]Ongoing projects.<\/strong><\/p>\n INSTITUTO MILENIO – CINV<\/strong><\/p>\n A\u00f1o: 2016-2021 REVEALING THE RELATIONSHIP BETWEEN HIGH-ORDER INTERDEPENDENCIES AND CRITICAL-LIKE BEHAVIOR IN BIOPHYSICAL NEURAL NETWORKS<\/strong><\/p>\n A\u00f1o: abril 2021 \u2013 marzo 2025 DESARROLLO DE UNA COBERTURA CUT\u00c1NEA COSTO EFECTIVA “PANEXPATCHTM” PARA EL TRATAMIENTO DE \u00daLCERAS VENOSAS<\/strong><\/p>\n A\u00f1o: enero 2022 \u2013 enero 2024 TEMPERATURE SENSING ON THE TRPM CHANNELS FAMILY: UNVEILING THE ROLE OF A FOLDING\/UNFOLDING REACTION AT THE C-TERMINUS DOMAIN<\/strong><\/p>\n A\u00f1o: abril 2022 \u2013 marzo 2026 EFFICIENT PRODUCTION OF PLANT-BASED PROTEINS FROM lemna sp.<\/em> (DUCKWEED) FOR HUMAN CONSUMPTION USING NANOBUBBLES<\/strong><\/p>\n A\u00f1o: octubre 2022 \u2013 septimbre 2025 SENSORY AND ELECTRIC BRAIN STIMULATION FOR NEUROREHABILITATION: FROM MECHANISMS TO CLINICAL PRACTICE<\/strong><\/p>\n A\u00f1o: diciembre 2021 \u2013 diciembre 2024 A GENERATIVE MODEL OF EEG DYNAMICAL FUNCTIONAL CONNECTIVITY TO PREDICT NEURODEGENERATIVE-DISEASE PROGRESSION: BRIDGING THE GAP BETWEEN BIOPHYSICAL AND MACHINE LEARNING MODELS<\/strong><\/p>\n A\u00f1o: abril 2020 \u2013 abril 2024 NOVEL EEG TOPOGRAPHY ANALISYS USING GRAPH SIGNAL PROCESSING AND NETWORK CONTROL THEORY<\/strong><\/p>\n A\u00f1o: marzo 2023 \u2013 marzo 2027 [vc_row css=”.vc_custom_1517921741410{padding-right: 70px !important;padding-left: 70px !important;background-color: #ffffff !important;}”][vc_column 0=””][vc_single_image image=”22468″ img_size=”1240×300″ alignment=”center”][stm_title title_tag=”h4″ title=”Line 5: Computational biology and molecular simulation.”][\/stm_title][stm_btn_simple btn_style=”custom” btn_color=”blue” btn_alignment=”right” btn_link=”url:https%3A%2F%2Fcinv.uv.cl%2Fen%2Fresearchlines%2F|||” btn_link_text=”Back to Research Lines”][vc_column_text] [\/vc_column_text][vc_tta_tabs style=”flat” shape=”square” color=”blue” spacing=”” alignment=”center” active_section=”1″ no_fill_content_area=”true”][vc_tta_section title=”DESCRIPTION” tab_id=”description”][vc_column_text] Researchers working on Line 5 study intercellular communication processes, ion channel activation, neural dynamics, and neural networks […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/pages\/23247"}],"collection":[{"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/comments?post=23247"}],"version-history":[{"count":17,"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/pages\/23247\/revisions"}],"predecessor-version":[{"id":46500,"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/pages\/23247\/revisions\/46500"}],"wp:attachment":[{"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/media?parent=23247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nConcurso:\u00a0Proyectos Institutos Milenio 2009 \u2013\u00a0ICM09-022-P
\nFinanciamiento: \u00a0Ministerio de Ciencia, Tecnolog\u00eda, Conocimiento e Innovaci\u00f3n
\nInvestigador Principal: Ram\u00f3n Latorre<\/a>
\nOtros Investigadores:\u00a0Juan Carlos S\u00e1ez<\/a>, Alan Neely<\/a>, Ana Mar\u00eda C\u00e1rdenas<\/a>, John Ewer<\/a>, Kathleen Whitlock<\/a>, Adri\u00e1n Palacios<\/a>, Tom\u00e1s P\u00e9rez-Acle<\/a>, Fernando Danilo Gonz\u00e1lez-Nilo<\/a>, Oliver Schmachtenberg<\/a>, Agust\u00edn Mart\u00ednez<\/a>, Patricio Orio<\/a>, Andr\u00e9s Ch\u00e1vez<\/a>, Pablo Moya<\/a>, Andrea Calixto<\/a>, Carlos Gonz\u00e1lez<\/a>
\nOtras Universidades o Instituciones: Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Pontificia Universidad Cat\u00f3lica, Universidad Andr\u00e9s Bello, Fundaci\u00f3n Ciencia y Vida<\/p>\n
\nConcurso: Fondecyt Regular 1211750
\nFinanciamiento: Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)
\nInvestigador Principal: Patricio Orio
\nOtros Investigadores:
\nOtras Universidades o Instituciones:<\/p>\n
\nConcurso: Fondef ID21I10153
\nFinanciamiento: Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)
\nInvestigador Principal: Danilo Gonzalez-Nilo
\nOtros Investigadores:
\nOtras Universidades o Instituciones:<\/p>\n
\nConcurso: Fondecyt Regular 1221498
\nFinanciamiento: Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)
\nInvestigador Principal: Danilo Gonzalez-Nilo
\nOtros Investigadores:
\nOtras Universidades o Instituciones:<\/p>\n
\nConcurso: Fondef ID22I10344
\nFinanciamiento: Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)
\nInvestigador Principal: Danilo Gonzalez-Nilo
\nOtros Investigadores:
\nOtras Universidades o Instituciones:<\/p>\n
\nConcurso: Anillo ACT210053
\nFinanciamiento: Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)
\nInvestigador Principal: Wael El-Deredy
\nOtros Investigadores: Ignacio Negr\u00f3n; Alejandro Weinstein
\nOtras Universidades o Instituciones:<\/p>\n
\nConcurso: Fondecyt Regular 1201822
\nFinanciamiento: Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica (CONICYT)
\nInvestigador Principal: Wael El-Deredy
\nOtros Investigadores:
\nOtras Universidades o Instituciones:<\/p>\n
\nConcurso: Fondecyt Regular 1231132
\nFinanciamiento: Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)
\nInvestigador Principal: Alejandro Weinstein
\nOtros Investigadores: Wael El-Deredy
\nOtras Universidades o Instituciones:[\/vc_column_text][\/vc_tta_section][\/vc_tta_tabs][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"