﻿{"id":23243,"date":"2017-07-27T04:33:11","date_gmt":"2017-07-27T04:33:11","guid":{"rendered":"http:\/\/www.cinv.edge.gaea.cl\/linea-3-genetica-y-desarrollo-del-sistema-nervioso\/"},"modified":"2023-05-08T21:52:43","modified_gmt":"2023-05-08T21:52:43","slug":"geneticsanddevelopment","status":"publish","type":"page","link":"https:\/\/cinv.uv.cl\/en\/geneticsanddevelopment\/","title":{"rendered":"L\u00ednea 3: Gen\u00e9tica y desarrollo del sistema nervioso"},"content":{"rendered":"<p>[vc_row css=&#8221;.vc_custom_1517921908437{padding-right: 70px !important;padding-left: 70px !important;background-color: #ffffff !important;}&#8221;][vc_column 0=&#8221;&#8221;][vc_single_image image=&#8221;22464&#8243; img_size=&#8221;1240&#215;300&#8243; alignment=&#8221;center&#8221;][stm_title title_tag=&#8221;h4&#8243; title=&#8221;Line 3: Genetics and development of the Nervous System.&#8221;][\/stm_title][stm_btn_simple btn_style=&#8221;custom&#8221; btn_color=&#8221;blue&#8221; btn_alignment=&#8221;right&#8221; btn_link=&#8221;url:https%3A%2F%2Fcinv.uv.cl%2Fen%2Fresearchlines%2F|||&#8221; btn_link_text=&#8221;Back to Research Lines&#8221;][vc_column_text]<\/p>\n<p>[\/vc_column_text][vc_tta_tabs style=&#8221;flat&#8221; shape=&#8221;square&#8221; color=&#8221;blue&#8221; spacing=&#8221;&#8221; alignment=&#8221;center&#8221; active_section=&#8221;1&#8243; no_fill_content_area=&#8221;true&#8221;][vc_tta_section title=&#8221;DESCRIPTION&#8221; tab_id=&#8221;description&#8221;][vc_row_inner 0=&#8221;&#8221;][vc_column_inner css=&#8221;.vc_custom_1472449168986{margin-bottom: 20px !important;}&#8221;][vc_column_text]<\/p>\n<p style=\"text-align: justify;\">Researchers in this line study the development and function of the nervous system using economically viable, genetically tractable, model systems in genetics (zebrafish, Drosophila, C. elegans) to investigate mechanisms that allow highly conserved neuropeptides and receptors to trigger different behaviors as well as the circadian control of neuroendocrine peptide networks; Mechanisms by which environment (inanition, nutrition, stress) and microbiota influence phenotype, behavior and their heritability; Mechanisms by which the neural immune interface in the olfactory epithelia regulate neurogenesis.<\/p>\n<p><a href=\"http:\/\/www.gaea.cl\/cinv\/wp-content\/uploads\/2017\/07\/LINEA-3.pdf\">Descarga PDF aqu\u00ed<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_separator 0=&#8221;&#8221;][\/vc_tta_section][vc_tta_section title=&#8221;TEAM&#8221; tab_id=&#8221;team&#8221;][vc_toggle title=&#8221;Researchers.&#8221;]<a href=\"https:\/\/cinv.uv.cl\/en\/members\/kwhitlock\/\" target=\"_blank\" rel=\"noopener noreferrer\">Kathleen Whitlock<\/a> \/ fono:(56) 32 2995510 \/ kathleen.whitlock@uv.cl<br \/>\n<a href=\"https:\/\/cinv.uv.cl\/en\/members\/acalixto\/\" target=\"_blank\" rel=\"noopener noreferrer\">Andrea Calixto<\/a> \/ fono: (56) 2 23289224 \/ tigonas@gmail.com, andrea.calixto@uv.cl<br \/>\n<a href=\"https:\/\/cinv.uv.cl\/en\/members\/angelina-palacios\/\">Angelina Palacios<\/a> \/ fono:(56) 32 2508191 \/ angelina.palacios@cinv.cl<br \/>\n<a href=\"https:\/\/cinv.uv.cl\/en\/members\/jewer\/\">John Ewer<\/a> \/ fono:(56) 32 2508187 \/ john.ewer@uv.cl[\/vc_toggle][vc_toggle title=&#8221;Associate Researchers.&#8221;][\/vc_toggle][vc_toggle title=&#8221;Postdoctoral Researchers.&#8221;][\/vc_toggle][vc_toggle title=&#8221;PhD Students.&#8221;]Blanca Aguila \/<br \/>\nEugene Mbar Tine \/\u00a0fono:(56) 32 2508103 \/\u00a0eugene.tine@cinv.cl<br \/>\nIlvanna Salas \/<br \/>\nJavier Cavieres \/\u00a0fono:(56) 32 2508103 \/\u00a0jicavier@gmail.com<br \/>\nSol Retamales \/ fono: (56) 32 2508203 \/ eretven at gmail.com<br \/>\nVictoria Collio \/ fono: (56) 32 2508203 \/ victoria.collio@gmail.com<br \/>\nValeria Silva \/\u00a0fono:(56) 32 2508103 \/ valeria.silva@cinv.cl[\/vc_toggle][\/vc_tta_section][vc_tta_section title=&#8221;FEATURED PUBLICATIONS&#8221; tab_id=&#8221;publications&#8221;][vc_row_inner 0=&#8221;&#8221;][vc_column_inner 0=&#8221;&#8221;][vc_column_text]<\/p>\n<ul>\n<li style=\"text-align: justify;\">Palominos, M. and <strong><a href=\"https:\/\/cinv.uv.cl\/members\/kwhitlock\/\">Whitlock, K.E.<\/a> <\/strong>(2021). The olfactory organ is populated by neutrophils and macrophages during early development. Front. Cell Dev. Biol., 18 January 2021 | https:\/\/doi.org\/10.3389\/fcell.2020.604030<\/li>\n<li style=\"text-align: justify;\">\n<p style=\"font-weight: 400;\">Ceriani, R., Calfun, C and\u00a0<a href=\"https:\/\/cinv.uv.cl\/members\/kwhitlock\/\"><strong>Whitlock, K.E.<\/strong>\u00a0<\/a>(2020).\u00a0<em>phoenixin<\/em>(<em>smim20<\/em>), a gene coding for a novel reproductive ligand, is expressed in the brain of developing and adult zebrafish. Gene Expression Patterns,\u00a0Gene Expr Patterns. Dec 29;39:119164. doi: 10.1016\/j.gep.2020.119164.<\/p>\n<\/li>\n<li style=\"text-align: justify;\">\n<p style=\"font-weight: 400;\">Torres-Paz, J., Tine, E. M., and\u00a0<a href=\"https:\/\/cinv.uv.cl\/members\/kwhitlock\/\"><strong>Whitlock, K.E.<\/strong>\u00a0<\/a>(2020). Dissecting the neural divide: A continuous neurectoderm gives rise to both the olfactory placode and olfactory bulb. International Journal of Developmental Biology,\u00a0Aug 25. doi: 10.1387\/ijdb.200097<\/p>\n<\/li>\n<li style=\"text-align: justify;\">\n<p style=\"font-weight: 400;\"><a href=\"https:\/\/cinv.uv.cl\/members\/kwhitlock\/\"><strong>Whitlock, K.E<\/strong><\/a>, Postlethwait, J., and Ewer, E. (2019) Neuroendocrinology of reproduction: Is gonadotropin-releasing hormone (GnRH) dispensable? Frontiers in Neuroendocrinology, Feb 22. pii: S0091-3022(19)30008-1. doi: 10.1016\/j.yfrne.2019.02.002.<\/p>\n<\/li>\n<li style=\"margin: 0px 0px 13px; text-align: justify; color: #333333;\">Palominos MF, Verdugo L, Gabaldon C, Pollak B, Ort\u00edz-Sever\u00edn J, Varas MA, Ch\u00e1vez FP,\u00a0<strong><a href=\"https:\/\/cinv.uv.cl\/members\/cgonzalez\/\">Calixto A.<\/a><\/strong> (2017). Transgenerational Diapause as an Avoidance Strategy against Bacterial Pathogens in\u00a0Caenorhabditis\u00a0elegans. MBio. 2017 Oct 10;8(5). pii: e01234-17. doi: 10.1128\/mBio.01234-17.<\/li>\n<li style=\"margin: 0px 0px 13px; text-align: justify; color: #333333;\">Selcho M, Mill\u00e1n C, Palacios-Mu\u00f1oz A, Ruf F, Ubillo L, Chen J, Bergmann G, Ito C, Silva V, Wegener C, <strong><a href=\"https:\/\/cinv.uv.cl\/members\/jewer\/\">Ewer J<\/a><\/strong>.(2017). Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila. Nat Commun. 8:15563. doi: 10.1038\/ncomms15563<\/li>\n<li style=\"margin: 0px 0px 13px; text-align: justify; color: #333333;\">Cortes-Campos C, Letelier J, Ceriani\u00a0R and<strong> <a href=\"https:\/\/cinv.uv.cl\/members\/kwhitlock\/\">Whitlock KE<\/a><\/strong> (2015). Zebrafish adult-derived\u00a0hypothalamic neurospheres generate gonadotropin-releasing\u00a0hormone (GnRH) neurons. Biol Open. 4(9):1077-86.<\/li>\n<li style=\"margin: 0px 0px 13px; text-align: justify; color: #333333;\">Torres-Paz J and <strong><a href=\"https:\/\/cinv.uv.cl\/members\/kwhitlock\/\">Whitlock KE<\/a> <\/strong>(2014). Olfactory sensory\u00a0system develops from coordinated movements within the\u00a0neural plate. Dev Dyn. 2014 Dec;243(12):1619-31.<\/li>\n<li style=\"margin: 0px 0px 13px; text-align: justify; color: #333333;\">Diao F, Mena W, Shi J, Park D, Diao F, Taghert P, <strong><a href=\"https:\/\/cinv.uv.cl\/members\/jewer\/\">Ewer J<\/a><\/strong> and White BH (2016). The Splice Isoforms of the\u00a0Drosophila Ecdysis Triggering Hormone Receptor have\u00a0developmentally distinct roles. Genetics. 202(1): 175-189.<\/li>\n<li style=\"margin: 0px 0px 13px; text-align: justify; color: #333333;\">Calf\u00fan C, Dom\u00ednguez C, <strong><a href=\"https:\/\/cinv.uv.cl\/members\/tperezacle\/\">P\u00e9rez-Acle T<\/a><\/strong>, <strong><a href=\"https:\/\/cinv.uv.cl\/members\/kwhitlock\/\">Whitlock KE<\/a>.<\/strong> (2016) Changes in Olfactory Receptor Expression Are Correlated With Odor Exposure During Early Development in the zebrafish (Danio rerio). Chem Senses. 1861(5):439-48.<\/li>\n<li style=\"margin: 0px 0px 13px; text-align: justify; color: #333333;\">Diao F, Ironfield H, Luan H, Diao F, Shropshire WC,<strong> <a href=\"https:\/\/cinv.uv.cl\/members\/jewer\/\">Ewer\u00a0J<\/a>,<\/strong> Marr E, Potter CJ, Landgraf M and White BH (2015).\u00a0Plug-and-Play Genetic Access to Drosophila Cell Types\u00a0using Exchangeable Exon Cassettes. Cell Rep. 10(8): 1410-\u00a01421.<\/li>\n<li style=\"margin: 0px 0px 13px; text-align: justify; color: #333333;\">Mena W, Diegelmann S, Wegener C, <strong><a href=\"https:\/\/cinv.uv.cl\/members\/jewer\/\">Ewer J<\/a>.<\/strong> (2016) Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulators. Elife. 2016 Dec 15;5. pii: e19686. doi: 10.7554\/eLife.19686.<\/li>\n<li style=\"margin: 0px 0px 13px; text-align: justify; color: #333333;\">Salazar C, Valdivia G, <strong><a href=\"https:\/\/cinv.uv.cl\/members\/alvaro-ardiles\/\">Ardiles AO<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/jewer\/\">Ewer J<\/a><\/strong>, <strong><a href=\"https:\/\/cinv.uv.cl\/members\/apalacios\/\">Palacios AG<\/a><\/strong>. (2016). Genetic variants associated with neurodegenerative Alzheimer disease in natural model. Biological Research. 49(1):14. Special Issue.<\/li>\n<li style=\"margin: 0px 0px 13px; text-align: justify; color: #333333;\"><strong><a href=\"https:\/\/cinv.uv.cl\/members\/acalixto\/\">Calixto A<\/a> <\/strong>(2015). Life without food and the implications for\u00a0neurodegeneration. Advances in Genetics, Volume 92. Kelley\u00a0M, Yochem J, Krieg M, Calixto A, Heiman MG, Kuzmanov A, Meli V, Chalfie M, Goodman MB, Shaham S, Frand A,\u00a0Fay DS (2015). FBN-1, a fibrillin-related protein, is required\u00a0for resistance of the epidermis to mechanical deformation\u00a0during C. elegans embryogenesis. eLife Mar 23;4.<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][vc_tta_section title=&#8221;PROJECTS&#8221; tab_id=&#8221;projects&#8221;][vc_column_text 0=&#8221;&#8221;]<strong>Ongoing projects.<\/strong><\/p>\n<p><strong>INSTITUTO MILENIO &#8211; CINV<\/strong><\/p>\n<p>A\u00f1o: 2016-2021<br \/>\nConcurso:\u00a0Proyectos Institutos Milenio 2009 \u2013 # ICM09-022-P<br \/>\nFinanciamiento: \u00a0Ministerio de Ciencia, Tecnolog\u00eda, Conocimiento e Innovaci\u00f3n<br \/>\nInvestigador Principal: <a href=\"https:\/\/cinv.uv.cl\/members\/rlatorre\/\">Ram\u00f3n Latorre<\/a><br \/>\nOtros Investigadores:\u00a0<a href=\"https:\/\/cinv.uv.cl\/members\/jsaez\/\">Juan Carlos S\u00e1ez<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/aneely\/\">Alan Neely<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/acardenas\/\">Ana Mar\u00eda C\u00e1rdenas<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/jewer\/\">John Ewer<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/kwhitlock\/\">Kathleen Whitlock<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/apalacios\/\">Adri\u00e1n Palacios<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/tperezacle\/\">Tom\u00e1s P\u00e9rez-Acle<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/fgonzalez\/\">Fernando Danilo Gonz\u00e1lez-Nilo<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/oschmachtenberg\/\">Oliver Schmachtenberg<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/amartinez\/\">c<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/porio\/\">Patricio Orio<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/achavez\/\">Andr\u00e9s Ch\u00e1vez<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/pmoya\/\">Pablo Moya<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/acalixto\/\">Andrea Calixto<\/a>, <a href=\"https:\/\/cinv.uv.cl\/members\/cgonzalez\/\">Carlos Gonz\u00e1lez<\/a><br \/>\nOtras Universidades o Instituciones: Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Pontificia Universidad Cat\u00f3lica, Universidad Andr\u00e9s Bello, Fundaci\u00f3n Ciencia y Vida<\/p>\n<p><strong>NODOS PARA EL DESARROLLO EN INVESTIGACI\u00d3N DE LABORATORIOS NATURALES EN CHILE<\/strong><\/p>\n<p>A\u00f1o: enero 2022 \u2013 diciembre 2023<br \/>\nConcurso: NODOSLN0006<br \/>\nFinanciamiento: Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)<br \/>\nInvestigador Principal: <a href=\"https:\/\/cinv.uv.cl\/members\/acalixto\/\">Andrea Calixto\u00a0<\/a><br \/>\nOtros Investigadores:<br \/>\nOtras Universidades o Instituciones: Universidad Cat\u00f3lica del Norte, Universidad de Atacama, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Centro de Estudios Avanzados en Zonas \u00c1ridas (CEAZA), Universidad de Playa Ancha, AQUA Pac\u00edfico, Confederaci\u00f3n Nacional de Pescadores Artesanales de Chile<\/p>\n<p><strong>INTERESPECIES EFFECTORS OF A TRANSGENERATIONAL MEMORY OF BACTERIAL INFECTION IN <em>C. elegans<\/em><\/strong><\/p>\n<p>A\u00f1o: abril 2022 \u2013 marzo 2026<br \/>\nConcurso: Fondecyt Regular 1220650<br \/>\nFinanciamiento: Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)<br \/>\nInvestigador Principal: <a href=\"https:\/\/cinv.uv.cl\/members\/acalixto\/\">Andrea Calixto\u00a0<\/a><br \/>\nOtros Investigadores:<br \/>\nOtras Universidades o Instituciones:<\/p>\n<p><strong>CIRCADIAN CONROL OF <em>Drosophila<\/em> BEHAVIOR<\/strong><\/p>\n<p>A\u00f1o: abril 2022 \u2013 marzo 2026<br \/>\nConcurso: Fondecyt Regular 1221270<br \/>\nFinanciamiento: Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)<br \/>\nInvestigador Principal: <a href=\"https:\/\/cinv.uv.cl\/members\/jewer\/\">John Ewer<\/a><br \/>\nOtros Investigadores:\u00a0 Co PI <a href=\"https:\/\/cinv.uv.cl\/members\/kwhitlock\/\">Kathleeen Whitlock<\/a><br \/>\nOtras Universidades o Instituciones:<\/p>\n<p><strong>VALIDACI\u00d3N DE UN PROTOCOLO DE MANEJO DE LUZ Y OSCURIDAD PARA MODIFICAR EL RELOJ BIOL\u00d3GICO DE CONDUCTORES DURANTE LOS TURNOS NOCTURNOS CON EL FIN DE MEJORAR SU DESEMPE\u00d1O Y SALUD<\/strong><\/p>\n<p>A\u00f1o: septiembre 2022 \u2013 septiembre 2024<br \/>\nConcurso: Fondef ID22I10053<br \/>\nFinanciamiento: Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)<br \/>\nInvestigador Principal: <a href=\"https:\/\/cinv.uv.cl\/members\/jewer\/\">John Ewer\u00a0<\/a><br \/>\nOtros Investigadores:<br \/>\nOtras Universidades o Instituciones:<\/p>\n<p><strong><span class=\"im\">LA ALEGR\u00cdA DE LOS SENTIDOS<\/span><\/strong><\/p>\n<p>A\u00f1o: enero 2023 \u2013 enero 2024<br \/>\nConcurso: CIENCIA P\u00daBLICA CP22-P042<br \/>\nFinanciamiento: Subsecretar\u00eda De Ciencia, Tecnolog\u00eda, Conocimiento E Innovaci\u00f3n<br \/>\nInvestigador Principal: <a href=\"https:\/\/cinv.uv.cl\/members\/kwhitlock\/\">Kathleen Whitlock<\/a><br \/>\nOtros Investigadores: <a href=\"https:\/\/cinv.uv.cl\/members\/jewer\/\">John Ewer\u00a0<\/a><br \/>\nOtras Universidades o Instituciones:[\/vc_column_text][\/vc_tta_section][\/vc_tta_tabs][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row css=&#8221;.vc_custom_1517921908437{padding-right: 70px !important;padding-left: 70px !important;background-color: #ffffff !important;}&#8221;][vc_column 0=&#8221;&#8221;][vc_single_image image=&#8221;22464&#8243; img_size=&#8221;1240&#215;300&#8243; alignment=&#8221;center&#8221;][stm_title title_tag=&#8221;h4&#8243; title=&#8221;Line 3: Genetics and development of the Nervous System.&#8221;][\/stm_title][stm_btn_simple btn_style=&#8221;custom&#8221; btn_color=&#8221;blue&#8221; btn_alignment=&#8221;right&#8221; btn_link=&#8221;url:https%3A%2F%2Fcinv.uv.cl%2Fen%2Fresearchlines%2F|||&#8221; btn_link_text=&#8221;Back to Research Lines&#8221;][vc_column_text] [\/vc_column_text][vc_tta_tabs style=&#8221;flat&#8221; shape=&#8221;square&#8221; color=&#8221;blue&#8221; spacing=&#8221;&#8221; alignment=&#8221;center&#8221; active_section=&#8221;1&#8243; no_fill_content_area=&#8221;true&#8221;][vc_tta_section title=&#8221;DESCRIPTION&#8221; tab_id=&#8221;description&#8221;][vc_row_inner 0=&#8221;&#8221;][vc_column_inner css=&#8221;.vc_custom_1472449168986{margin-bottom: 20px !important;}&#8221;][vc_column_text] Researchers in this line study the development and function of the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/pages\/23243"}],"collection":[{"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/comments?post=23243"}],"version-history":[{"count":17,"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/pages\/23243\/revisions"}],"predecessor-version":[{"id":46506,"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/pages\/23243\/revisions\/46506"}],"wp:attachment":[{"href":"https:\/\/cinv.uv.cl\/en\/wp-json\/wp\/v2\/media?parent=23243"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}