Tomas Perez-Acle

Molecular Simulation and Computational Biology

Professor
Centro Interdisciplinario de Neurociencia de Valparaíso

Associated Researcher
Computational Biology Lab (DLab)
Center for Mathematical Modeling (CMM)

Associated Researcher
Fundación Ciencia para la Vida
Currículum Vitae  

Contact information:

E-mail: tomas at dlab dot cl
Phone:    (56) 2- 23672000
Address: Gran Bretaña 1111, Playa Ancha. Valparaíso. Chile.

Research overview:

The main objective of DLab is to produce multiscale computational models to explain complex biological phenomena. To do so, we use tools coming from mathematical modeling and high performance computing (HPC). At the microscale (atomic), we use molecular modeling and molecular simulations to understand the fundamental properties that govern biological processes such as intercellular communication, membrane transport and molecular recognition. At the meso and macroscale, we use rule-based modeling and network topology to produce  and characterize stochastic simulations of cell signaling, gene regulation and infectious diseases.

 Selected Publications:

  • González A, Perez-Acle T, Pardo L, Deupi X. (2011) Molecular basis of ligand dissociation in B-adrenergic receptors. PLoS One. 6(9):e23815. Epub 2011 Sep 7. PMID: 21915263
  • González-Nilo F, Pérez-Acle T, Guínez-Molinos S, Geraldo DA, Sandoval C, Yévenes A, Santos LS, Laurie VF, Mendoza H, Cachau RE. (2011) Nanoinformatics: an emerging area of information technology at the intersection of bioinformatics, computational chemistry and nanobiotechnology. Biol Res. X;44(1):43-51. doi: 10.4067/S0716-97602011000100006. Epub 2011 May 11.
  • Lizama C, Lagos CF, Lagos-Cabré R, Cantuarias L, Rivera F, Huenchuñir P, Pérez-Acle T, Carrión F, Moreno RD. (2009) Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes. J Cell Physiol. 2009 Nov;221(2):296-305.
  • Gonzalez A, Duran LS, Araya-Secchi R, Garate JA, Pessoa-Mahana CD, Lagos CF,Perez-Acle T. Computational modeling study of functional microdomains in cannabinoid receptor type 1. Bioorg Med Chem. 2008 Apr 15;16(8):4378-89. Epub 2008 Feb 26.
  • Hantavirus Gc glycoprotein: evidence for a class II fusion protein.  (2005)  Tischler ND, Gonzalez A, Perez-Acle T, Rosemblatt M, Valenzuela PD. J Gen Virol. 2005 Nov;86(Pt 11):2937-47.
  • Strobel P, Allard C, Perez-Acle T, Calderon R, Aldunate R, Leighton F. Myricetin,  (2005) Quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. Biochem J.  Mar 15;386(Pt 3):471-8.