Germán Miño

Postdoctoral Researcher

“Centro Interdisciplinario de Neurociencia de Valparaíso”.
Research Area: Molecular Biophysics.
Centro de Bioinformática y Biología Integrativa, Professor Fernando Gonzalez, and Electro physiology Laboratory, Professor Carlos Gonzalez

Ph.D. in Molecular Physicochemistry, Universidad Andrés Bello, Chile (Year 2010).
Graduate in Biochemist, Univeridad de Chile, Chile (Year 1998)

Curriculum Vitae

Contact Information:
E-mail: german.mino at cinv.cl
Phone: (56)-(2)- 770 3628 / 02 2770 36 12 (Secretary)
Fax: (56)-( 2)-2770 36 12

Address: Av. Republica 239. Santiago Centro. Santiago

Research Statement:

My research is conducted using molecular simulation methods, namely, quantum chemistry, classical molecular dynamics and ab initio molecular dynamics. With these computational methods I characterize the operation of the proton channel Hv1. In particular, I am studying the pKa modulation of key residues in this channel, which consists of four transmembrane α-helix containing filter selectivity for protons. The study of classical trajectories have shown that slight conformational changes in key residues of the open channel HV1. Molecular dynamics calculations “ab initio” have shown that these minor conformational changes may modulate the acid/base properties of the selectivity filter.
Another relevant area of my research involves the study of thermal properties of proteins as molecular level. In particular TRPV1 is a heat-activated ion channel that sense noxious heat in living beings. The molecular level heat activation pathways implicated in operation of this channel are largely unknown. Recent findings have shown empirical correlations between the heat flow in proteins and the cognate allosteric communication pathways of them. Thus by using computational tools derived from molecular dynamics simulations and statistical thermodynamic of proteins I study the allosteric communication and heat diffusion pathways and the structural underpinnings involved in the operation of this thermal sensor.

Publications:

  1. German A. Miño-Galaz and Gonzalo Gutierrez. Hydrogen bonds and asymmetrical heat diffusion in a-Helices. A Computational Analysis.  Submitted. 
  2. Germán A. Miño-Galaz (2015) Allosteric Communication Pathways and Thermal Rectification in PDZ-2 Protein: A Computational Study. J. Phys. Chem. B, Accepted
  3. Miño G, Barriga R and Gutierrez G (2014) Hydrogen bonds and heat diffusion in α-helices: a computational study. J Phys Chem B. 118(34):10025-34
  4. German Miño, Mauricio Baez and Gonzalo Gutierrez (2013) Effect of mutation at the interface of Trp-repressor dimeric protein: a steered molecular dynamics simulation. European Biophysics. 42(9):683-90
  5. Vicente D. Samith*, German Miño, Esteban Ramos-Moore and Nicolás Arencibia-Miranda (2013) Effects of pluronic F68 micellization on the viability of neuronal cells in culture . Journal of Applied Polymer Science. 130 (3): 2159–2164
  6. Germán Miño and Renato Contreras. (2010) Non electrostatic components of short and strong hydrogen bonds induced by compression inside fullerenes. Chemical Physics Letters 486: 119–122.
  7. Germán Miño and Renato Contreras. (2009) On the role of short and strong hydrogen bonds on the mechanism of action of a model Chymotrypsine active site, Journal of Physical Chemistry A 113:5769-5772
  8. Weiss-Lopez B, Mino G, Araya-Maturana R and Tracey A. (2000) Average orientation and location of benzyl alcohol-d(5) and alkyl benzyl-d(5) ethers in anionic nematic lyotropic liquid crystals. Langmuir (2000) 16: 4040-4044

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