Expositor: Nathan D. Lawson, Ph.D. Professor Department of Molecular, Cell, and Cancer Biology. University of Massachusetts Medical School
Fecha: viernes 24 de marzo 2017, 12:00 – 13:00 hrs. , Café y galletas 11:45 hrs
Lugar: Auditorio de la Facultad de Ciencias. Av. Gran Bretaña 1111, Playa Ancha, Valparaíso
How to make a blood vessel sprout.
The formation of new blood vessels from pre-existing ones, a process known as angiogenesis, is essential for embryonic growth and is associated with a number of pathological settings. Given the major benefits of the zebrafish – namely, rapidly developing transparent embryos and genetic amenability – this model system has enabled detailed analysis and genetic dissection of morphogenetic processes, including blood vessel development. This seminar will highlight our work over the past several years using the zebrafish to discover new molecular and cellular mechanisms required for developmental angiogenesis. In particular, I will highlight our application of both forward and reverse genetic approaches to dissect the signaling pathways important for angiogenesis. This will include an overview of our efforts to develop and apply programmable nucleases for genome modification and targeted gene knockout in zebrafish.