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MINI CURSO: “INMUNOENSAYOS TIPO ELISA PARA INMUNODIAGNOSTICO Y DETECCION DE ANALITOS CON ANTICUERPOS POLI Y MONOCLONALES

INSCRIPCIONES AQUÍ!!

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CINV-Max Planck Tandem Group Competition

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What do we know about the senses?

CINV Tertulias Porteñas
What do we know about the senses?

“What do we know about the senses?”, is the question on the table Monday, the 16th at 19:00 o’clock in the Aula Magna of Facultad de Derecho of the Universidad de Valparaíso.

Want to know more about CINV´s Tertulias porteñas? Click here

On this occasion the guests will be:

 Pascual Ibáñez: Spanish wine expert, founder of Escuela de los Sentidos

More info about him here


 

 

 

 

 

 

 

 José Pérez de Arce, Musician and visual artist, who studies pre Columbian music and seeks to understand the senses from the anthropologic perspective 

More info about him here

 

 

 

 

 

 

  

 Kathleen Whitlock,  CINV Scientists, who studies the fishes’ sense of smell. 

More info here

 

 

 

 

 

 

 

 

Like always, Cristian Warknen will moderate the panel.

You can learn more about his work here. 

 

 

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Meeting CINV – Max Planck 2014

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CINV Postdoctoral Fellowship Program 2014

       

The Centro Interdisciplinario de Neurociencia de Valparaíso (CINV, http://cinv.uv.cl/en/), at the Universidad de Valparaiso, Valparaiso, Chile, invites young postdoctoral researchers to apply for a Postdoctoral Fellowship at the CINV. The purpose of this program is to support highly motivated and outstanding PhD graduates students from any country who wish to initiate or continue a scientific project in one of CINV’s labs, which are: 

Structure and Function of Molecular Sensors:   http://cinv.uv.cl/en/structure-and-function-of-molecular-sensors/

Cellular Signaling:   http://cinv.uv.cl/en/cellular-signaling/

Genetics and Development of the Nervous System:   http://cinv.uv.cl/en/genetic-and-developmental-neuroscience/

Systems and Circuits Neuroscience:   http://cinv.uv.cl/en/sensory-system/

Molecular Simulation and Computational Biology:   http://cinv.uv.cl/en/molecular-simulation-and-computational-biology/

For more details please visit our webpage   http://cinv.uv.cl/en/   and contact CINV scientist researchers in your area of interest:   http://cinv.uv.cl/en/researchers/

The successful candidate will receive a one-year fellowship, and a second year funding will be subject to a competitive renewal. CINV fellows are expected to apply during their first year for external funding [e.g. FONDECYT http://www.conicyt.cl/fondecyt] to support their following years at CINV.

The monthly salary will be commensurable with FONDECYT postdoctoral salary fellowships. A formal agreement, between CINV and the awarded candidate, will establish the legal conditions of this scholarship.

Requirements:

       I. PhD or Doctor’s degree, obtained within five years prior to March 1st, 2014.
       II. The following documents to be included in the application:

1. Research statement
2. CV, including principal publications and activities (Max. 3 pages)
3. Research proposal (Max. 3 pages), including:

               a) Summary (1 page)
               b) Methods and Analysis
               c) Gantt chart, indicating specific objectives to be fulfilled
               d) Expected results and projections

4. Two confidential letters of recommendation, including one from the PhD tutor.
5. Support letter from a CINV researcher (http://cinv.uv.cl/en/researchers/)

Antecedents, letters of recommendation and support should be electronically sent to contacto@cinv.cl  before December 28th, 2013.

A Review Panel, including CINV researchers will communicate results by January 14th, 2014. The panel reserves the right to declare the competition void if none of the applicants are deemed suitable.

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Organism`s Protein Causes Genetics Deafness

Research from the Centro Interdisciplinario de Neurociencia, of Universidad de Valparaíso:

Organism`s Protein Causes Genetics Deafness

Dr. Agustín Martinez, of the CINV, participated last Sunday in “Hacia la mañana”, the scientific segment of the Puerto de Ideas Festival.

One out of every 1500 people born has hearing problems

Dr. Agustín Martínez seeks to understand the origin of genetic deafness and to search strategies for future therapies. Dr. Martínez, a biologist, is working on the mutations of an organism’s protein which is responsible for 50% of the congenital disorders.

 In his exhibition “De la comunicación intercelular a la sordera genética, un futuro desafiante” (“From intercellular communication to the genetic deafness, a challenging future”) displayed last Sunday, November 10th, in the Parque Cultural de Valparaiso, at the Puerto Ideas Festival, the biologist presented his discovery, which in the words of Dr. Martínez “is a public health problem”.

 Furthermore, Juan Carlos García, CINV Manager, remarked that Dr. Martínez’s work shows – “the role that young researchers play in, addressing different health problems and disease that affect Chile, connecting science and the society, and recognizing the contribution for the human development”

 Hearing problems

According to Dr. Martinez, an estimated one of 1.500 newborns has hearting problems”.  Half of patients with genetic deafness have mutations in a protein called “conexin 26”. The severity of this condition varies. The challenge is to develop future therapies in order to modulate the protein and improve the conditions of patients.

 Two types of deafness

According to Dr. Martínez the problem with this protein is that it can manifest in two types of deafness. One of them is the non-syndromic, which affects about 98% of the cases where the damage is only related to the auditory system. However, the other 2% of people shows a syndromic condition associated with serious skin problem that could cause death.

Our skin has various layers and is a very important organ because it prevents dehydration and protects us from the environment and its pathogens. People with this type of syndromic deafness loose skin layers. When this loss is serious people have to live under insolated conditions, and risk a disease related death. 

To understand the origin of thise typologies, one must recognize the pathological mechanisms of the different mutations of the conexine 26, whose normal function is in some structures called “gap junctions” which allow communication between cells. Dr. Martinez explains that although this mutation has been studied for one decade, we still have much to learn about the pathological mechanism of the mutations.

Nevertheless, in the CINV laboratories, Dr. Martínez together with his Doctoral students have discovered some differences between the mutations of the coexine 26 which causes syndromic deafness and between the one which causes non-syndromic deafness. In the first case, there is a observable loss of the protein function, meanwhile in the second case; there is a “gain” for the function, “which is impulse by the abnormal interaction of the mutant conexine 26 with other protein that is in the skin”.

Medicine creation

With this research, a strategy is being developed to combat deafness using skin alteration, in order to generate a medicine that inhibits the protein function. “This is a midterm challenge, which could prove to be a treatment for patients with this syndromic condition”. Additionally, Dr. Martínez adds they already know some molecules that can “block the protein activity and potentially could be used as therapy for curing the skin illness.

However, to cure the deafness, the situation is more complicated, because elaborate genetics therapies which allow the modulation the mutation directly and/or replace the mutated gene, are necessary. “Our goal is to cure the deafness, but that is a long term plan” admits Dr. Martínez.

Currently, the CINV scientists are working at a basic level with cellular lines and transgenic animals samples. However, various international examples provide hope for this cure, because the studies of others genes related to deafness are being developed.  

But beyond the contribution to future therapies, Dr. Martínez recognizes the importance of understanding this alteration. “An understanding about how illnesses occur and the mechanisms involved in it, create a better understanding of the physiology of those organs. But also, this is a matter of public health we want people understand that scientists must investigate these problems and the state must continue to support financially these initiatives. . 

Scientific Profile

Agustin Martínez received his Doctorate in Biologics Sciences from Universidad Católica de Chile, and his post doctorate at  the Chicago University. Currently he works in Conexine and Intercelullar communication Laboratory of Centro Interdisciplinario de Neurociencia of Valparaíso, where he develops different lines of research, mainly orientated to understand the pathological mechanisms of genetics deafness. Furthermore, he is a professor and Director of the Master in Neuroscience program at the Universidad de Valparaíso. 

 

Source:  El Mercurio de Valparaíso, martes 12 de noviembre

http://www.mercuriovalpo.cl/impresa/2013/11/12/full/7/

 

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CINV Postdoctoral Fellowship Program 2014

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CINV Postdoctoral Fellowship Program 2014

       

The Centro Interdisciplinario de Neurociencia de Valparaíso (CINV, http://cinv.uv.cl/en/), at the Universidad de Valparaiso, Valparaiso, Chile, invites young postdoctoral researchers to apply for a Postdoctoral Fellowship at the CINV. The purpose of this program is to support highly motivated and outstanding PhD graduates students from any country who wish to initiate or continue a scientific project in one of CINV’s labs, which are: 

Structure and Function of Molecular Sensors:   http://cinv.uv.cl/en/structure-and-function-of-molecular-sensors/

Cellular Signaling:   http://cinv.uv.cl/en/cellular-signaling/

Genetics and Development of the Nervous System:   http://cinv.uv.cl/en/genetic-and-developmental-neuroscience/

Systems and Circuits Neuroscience:   http://cinv.uv.cl/en/sensory-system/

Molecular Simulation and Computational Biology:   http://cinv.uv.cl/en/molecular-simulation-and-computational-biology/

For more details please visit our webpage   http://cinv.uv.cl/en/   and contact CINV scientist researchers in your area of interest:   http://cinv.uv.cl/en/researchers/

The successful candidate will receive a one-year fellowship, and a second year funding will be subject to a competitive renewal. CINV fellows are expected to apply during their first year for external funding [e.g. FONDECYT http://www.conicyt.cl/fondecyt] to support their following years at CINV.

The monthly salary will be commensurable with FONDECYT postdoctoral salary fellowships. A formal agreement, between CINV and the awarded candidate, will establish the legal conditions of this scholarship.

Requirements:

       I. PhD or Doctor’s degree, obtained within five years prior to March 1st, 2013.
       II. The following documents to be included in the application:

1. Research statement
2. CV, including principal publications and activities (Max. 3 pages)
3. Research proposal (Max. 3 pages), including:

               a) Summary (1 page)
               b) Methods and Analysis
               c) Gantt chart, indicating specific objectives to be fulfilled
               d) Expected results and projections

4. Two confidential letters of recommendation, including one from the PhD tutor.
5. Support letter from a CINV researcher (http://cinv.uv.cl/en/researchers/)

Antecedents, letters of recommendation and support should be electronically sent to contacto@cinv.cl  before December 28th, 2013.

A Review Panel, including CINV researchers will communicate results by January 14th, 2014. The panel reserves the right to declare the competition void if none of the applicants are deemed suitable.

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III Escuela Latinoamericana de Neurociencia Computacional LACONEU 2014

 The principal aims of LACONEU 2014 Summer School are to disseminate and to develop Computational Neuroscience in Latin America, gathering researchers and students with common insterests in the beautiful city of Valparaiso, in Chile.

 

 

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