Opportunities

Job and academic opportunities.

Oportunidad Trabajo Técnicos CINV-UV

¿Quiere ser parte de un laboratorio interdisciplinario de Neurociencia? Esta es su oportunidad.

Mi laboratorio en el Centro Interdisciplinario de Neurociencia de Valparaíso (cinv.uv.cl), un Instituto de la Iniciativa Milenio, Universidad de Valparaíso, ha abierto un concurso para un cargo de Asistente de Investigación de tiempo completo.

Mi laboratorio esta interesado en el estudio de la estructura y función del sistema nervioso utilizando tanto el cerebro como la retina como modelo experimental. Estamos estudiando los procesos de codificación sensorial a nivel de la retina, una capa fotosensible que tapiza el fondo del ojo, a través del registro fisiológico simultáneo de cientos de neuronas en respuesta a una diversidad de estímulos visuales – tanto artificiales como naturales.

Nuestro principal objetivo es tratar de entender los procesos biológicos subyacentes a la codificación neuronal. Es decir ¿Cual es el alfabeto y posterior lenguaje que utiliza la retina para comunicarse con el cerebro?. El tejido nervioso corresponde a intrincadas y sofisticadas redes de neuronas que en función de las propiedades de sus constituyentes moleculares otorgan capacidad de recibir, codificar y transmitir señales biológicas en forma compacta y de manera eficiente.

Nosotros estamos interesados en el estudio de procesos fisiológicos que acompañan el deterioro sensorial y cognitivo durante el proceso de envejecimiento y/o de neurodegeneración.

Utilizamos en el laboratorio herramientas de fisiología utilizando matrices de 256 multi-electrodos (única en Chile), patch clamp. farmacología, robótica, modelos computacionales.

Mi laboratorio hace parte de una red internacional muy activa de colaboraciones incluyendo investigadores en Francia (INRIA, CNRS, INSERM); Estados Unidos (Johns Hopkins); Chile (UTFSM, UCH). Varios proyectos a presente financian mis investigaciones, Instituto Iniciativa Científica Milenio, ANR-Francia, Office Naval Research General.

Publicaciones Recientes Seleccionadas:

  1. Ardiles AO, Tapia-Rojas CC, Mandal M, Alexandre F, Kirkwood A, Inestrosa NC & Palacios AG. (2012) Post-synaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer’s disease. Proceeding National Academy of Science. 109 (34) 13835-13840.
  2. Ardiles A, Ewer J, Acosta ML, Kirkwood A, Martinez A, Ebensperger LA, Bozinovic  F,  Lee T, Palacios AG. (2013). Octodon degus (Molina 1782): A model in comparative biology and biomedicine. Cold Spring Harbor Protocols. 4: 312-18.
  3. Lowe J, Chang YL, Ardiles AO, Lim JC, Grey AC, Robertson KM, Danesh-Meyer HV, Palacios AG, Acosta ML. (2014). Alzheimer’s disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers. Alzheimer & Dementia. Vol 10(2):251-261
  4. Palacios-Muñoz A, Escobar MJ, Vielma A, Araya J, Astudillo A, Valdivia G, García IE, Hurtado J, Schmachtenberg O, Martínez AD, Palacios AG. (2014). Role of connexin channels in the retinal light response of a diurnal rodent. Frontiers in Cellular Neuroscience 8(249):1-13.
  5. Alex H Vielma; Adolfo Agurto; Joaquín Valdés; Adrián G Palacios; Oliver Schmachtenberg. (2014). Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells. Plos One 9(10):1-16.
  6. Claudio Elgueta, Alex Harry Vielma, Adrian G Palacios and Oliver Schmachtenberg. (2015). Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Frontiers in Cellular Neuroscience 9(6):1-11.
  7. Du LY, Lily Y-L Chang, Alvaro O Ardiles, Cheril Tapia-Rojas, Joaquin Araya, Nibaldo C Inestrosa, Adrian G Palacios and Monica L Acosta. (2015). Alzheimer’s disease-related protein expression in the retina of aged Octodon degus. Plos One;10(8):e0135499. doi: 10.1371/journal.pone.0135499.
  8. Claudia Salazar, Gonzalo Valdivia, Álvaro O Ardiles, John Ewer, Adrián G Palacios. (2016). Genetic variants associated with neurodegenerative Alzheimer disease in natural models. Biol Res (2016) 49:14 DOI 10.1186/s40659-016-0072-9.
  9. Vega-Zuniga T, Medina FS, Karten HJ, Marín G, Letelier JC, Palacios AG, Nemec P, Schleich CE, Mpodozis J. (2017). Selective binocular vision loss in two subterranean caviomorph rodents: Spalacopus cyanus and Ctenomys talarum. Scientific Reports | 7:41704 | DOI: 10.1038/srep41704. 1-12.
  10. Palacios A.G, Escobar M.J., Céspedes E. (2017). Missing colors: an enactivist approach to perception. Constructivist Foundations, Volume 13, Number 1, pp 117-125 (link).
  11. Elgueta C, Leroy F, Schmachtenberg O, Palacios AG. 2017. Electrical coupling between A17 cells enhances reciprocal inhibitory feedback to rod bipolar cells”. Under revisión. Scientific Reports.
  12. Herzog R, Marıa-Jose Escobar, Adrian G. Palacios, Bruno Cessac. 2017. Dimensionality Reduction on Maximum Entropy Models on Spiking Networks. Plos Computational Biology. To be Submitted

Postulación abierta a partir del 10 de enero 2018 y hasta llenar el cargo. Inicio del trabajo a partir del 1 de marzo 2018. Duración mínima 12 meses. El cargo inicialmente será a honorarios, el cual incluirá las cargas laborales obligatoria. Luego de un periodo de prueba se podrá generar un contrato de tipo contrata.

Antecedentes deseables

  • Formación Bioquímico/a o equivalente.
  • Dominio del Ingles (medio, avanzado).
  • Experiencia laboral en áreas de la Bioquímica, Fisiología o equivalente.

Para postular enviar (PDF)

  • CV completo, incluyendo experiencia profesional y publicaciones si las hay.
  • Nombre de dos Profesionales que puedan recomendarlo.
  • Carta de Postulación y Motivación.
  • Aspiraciones Salariales.

Mayores informaciones y postulación:

 

Adrián Palacios

Email: adrian.palacios@uv.cl

WEB: http://cinv.uv.cl/apalacios

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Two Postdoctoral Positions on Ion Channels Studies

Two Postdoctoral Positions on Ion Channels Studies

 

Funded by CONICYT Grant ACT-1104: Voltage Sensor of ion channels: from structure to function. Applications are invited for two Postdoctoral Positions to study ion channels at Universidad de Valparaiso and Universidad del Desarrollo, Chile.

Required experience and Skills:

The aim of this project is to understand the molecular mechanisms underlying the way that connexin and pannexin voltage-dependent channels are operate. The project is focusing in the voltage sensor domain of hemichannels, using molecular biology, classic electrophysiology (patch clamp) and voltage clamp fluorometry (VCF) techniques. The candidate`s work should involve with the Connexin and Pannexin, and BK, Hv and Ca Channels Anillo-Grant studies under Drs. Carlos González, Alan Neely, Agustín Martínez, Mauricio Retamal and Wendy González. Supervision will be at the Universidad de Valparaíso or/and Universidad del Desarrollo or / and Universidad de Talca, in Valparaíso, Santiago and Talca.

To apply

Candidates must have a PhD degree in Biochemistry, Biology or a closely related field, three or more peer-reviewed publications in a relevant research area.

Applicants must submit background, including an up to date resume, certificates of degree, one letter indicating motivation and two references letters of academics supporting your application.

Primary localization: Santiago de Chile

Job time: Full time

Screening of applications is ongoing and will continue until this position is filled.

Please send the information to Prof. Carlos González, e-mail :carlos.gonzalezl@uv.cl

Subject: CINV-Anillo 2012

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CINV Postdoctoral Fellowship Program 2015

 

The Centro Interdisciplinario de Neurociencia de Valparaíso (CINV, http://cinv.uv.cl), at the Universidad de Valparaiso in Valparaiso, Chile, invites young postdoctoral researchers to apply for a Postdoctoral Fellowship at the CINV. The purpose of this program is to support outstanding and highly motivated PhD graduates from any country who wish to initiate or continue a scientific project in one of CINV’s labs, which are:

  1. Structure and Function of Molecular Sensors: http://cinv.uv.cl/en/structure-and-function-of-molecular-sensors/
  2. Cellular Signaling: http://cinv.uv.cl/en/cellular-signaling/
  3. Genetics and Development of the Nervous System: http://cinv.uv.cl/en/genetic-and-developmental-neuroscience/
  4. Systems and Circuit Neuroscience: http://cinv.uv.cl/en/sensory-system/
  5. Molecular Simulation and Computational Biology: http://cinv.uv.cl/en/molecular-simulation-and-computational-biology/

For more details, please visit our webpage http://cinv.uv.cl/en/ and contact CINV scientists in your area of interest: http://cinv.uv.cl/en/researchers/
The successful candidate will receive a one-year fellowship. A second year of funding will be subject to competitive renewal. Granted CINV fellows are expected to apply in May 2015 for external funding [e.g. FONDECYT http://www.conicyt.cl/fondecyt] to support their following years at CINV.
The monthly salary will be 1.5 million Chilean pesos, equivalent to ~2600 USD at present (August 6, 2014). A formal agreement between CINV and the awardee will establish the legal conditions of this scholarship.

Requirements:
I.       PhD or equivalent obtained within five years prior to March 1st, 2015.
II.     The following documents to be included in the application:
           1. Research statement
           2. CV, including principal publications and activities (Max. 3 pages)
           3. Research proposal (Max. 3 pages), including:
                      a) Summary (1 page)
                      b) Methods and Analysis
                      c) Gantt chart, indicating specific objectives to be fulfilled
                      d) Expected results and projections
           4. Two letters of recommendation, including one from the PhD tutor.
           5. A letter of commitment from the CINV researcher at whose laboratory the project will be carried out (http://cinv.uv.cl/en/researchers/).

Antecedents, letters of recommendation and commitment should be electronically sent to postdoc@cinv.cl before the 1st of December, 2014. Incomplete applications will not be considered. No documents will be received after this deadline.

A review panel of CINV researchers will communicate the results of this competition by December 15, 2014. The panel reserves the right to declare the competition void if none of the applicants are deemed suitable.

 

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Multiple Positions Available

Our lab is currently recruiting pre- and postdoctoral candidates with different backgrounds, skills and qualifications. We are using a combination of electrophysiology, optogenetics, and cellular biology approaches to understand mechanisms of neuronal communication and its regulation by different neuromodulators. We are interested in researchers with backgrounds in all biological disciplines, including electrophysiology, cellular/molecular biology, neuroscience, imaging, genetics, biochemistry, and biophysics.

Postdocs: Applicants should email a letter of intent, CV and names/contact information for 3 references that can provide a detailed account of your accomplishments and abilities to andres.chavez@einstein.yu.edu. 
Some experience with neuronal recording using patch clamp electrophysiology is highly preferred.

Graduate Students: Our lab can accept students from our PhD and Master programs at the Universidad de Valparaiso as well as from any graduate program in Chile. Students interested in a lab rotation should email a cover letter and CV to andres.chavez@einstein.yu.edu.

Undergraduates: Students at different undergraduate institutions are welcome to apply to our lab to gain research experience and to perform their undergraduate thesis work. Interested students should email andres.chavez@einstein.yu.edu.

 

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