Angelica Escobar

Postdoctoral  Felow

Psychiatric Genetics Lab.

Research Area: Dopamine system, compulsive behavior, anxiety disorders, glutamate transporter 3.
PhD. In Cellular and Molecular Biology, Pontificia Universidad Católica de Chile (2016)
Pharmacist, Pontificia Universidad Católica de Chile (2010)

Curriculum Vitae

Contact information:

Email: angeescobar.m@gmail.com
Phone number: (56) 32 250 80 39
Address: Laboratorio Dr. Pablo Moya, Facultad de Ciencias, Universidad de Valparaiso, Av. Gran Bretaña 1111, Playa Ancha. Valparaiso.

Research Statement:

Obsessive compulsive disorder (OCD) is a psychiatric disease. Genetic studies have positively correlated gene variants of SLC1A1 with OCD. SLC1A1 codifies for the neuronal glutamate transporter excitatory amino acid carrier 1 (EAAT3). Our laboratory developed a new mouse model of OCD based in the overexpression of EAAT3 on neurons that receive glutamate inputs (CamKII-EAAT3 OE). As in the disease, CamKII- EAAT3 OE mice display anxiety behaviors and repetitive behaviors. On the other hand, modifications on dopamine neurotransmission underlay the development of OCD.  The objective of my research is to study the impact of EAAT3 overexpression in dopamine neurotransmission and how those modifications can lead to the development of compulsive behavior.

Publications.

Peer-reviewed Journal articles.

Escobar AP, González MP, Meza RC, Noches V, Henny P, Gysling K, España RA, Fuentealba JA, Andrés ME. Mechanisms of kappa opioid receptor potentiation of dopamine D2 receptor function in quinpirole-induced locomotor sensitization in rats. Int J Neuropsychopharmacol. 2017 May 22. [Epub ahead of print]

Escobar AP, Cornejo FA, Olivares-Costa M, González M, Fuentealba JA, Gysling K, España RA, Andrés ME. Reduced dopamine and glutamate neurotransmission in the nucleus accumbens of quinpirole-sensitized rats hints at inhibitory D2 autoreceptor function. J Neurochem. 2015 Sep; 134(6):1081-90.

Escobar Adel P, Cornejo FA, Andrés ME, Fuentealba JA. Repeated treatment with the kappa opioid receptor agonist U69593 reverses enhanced K+ induced dopamine release in the nucleus accumbens, but not the expression of locomotor sensitization in amphetamine-sensitized rats. Neurochem Int. 2012. Mar; 60(4):344-9.