Adrian G. Palacios

Circuits and Systems Neuroscience

Universidad de Valparaiso, Professor

Principal Investigator, CINV-UV

Ph.D. in Neuroscience (1991) Université de Pierre et Marie Paris VI, France

2008-2010 Professor Visiting Researcher CORTEX INRIA-UHP et Nancy 2 and CREA Ecole Polytechnique, France.

Associate Investigator, Instituto de Sistemas Complejos de Valparaiso, Valparaiso.

Contact Information:
E-mail: adrian.palacios at
Phone: (56)-(32)-2508048

Pasaje Harrington 287, Playa Ancha
Valparaíso, 2360102, Chile


 Curriculum Vitae Resume  Palacios_CV_2016


Research Statement

1) Sensory Biology – Visual System: Retinal Physiology using multi-electrodes / Patch Clamp

2) Neurodegeneratives process in Alzheimer rodent models: Behavior / Synaptic Plasticity 

3) Computational Neuroscience and Neural Coding in retina. 

Sensory systems must ultimately be understood at all the biological levels of analysis, from molecular events in cells to the behavioral repertoires of animals seen in the ecological conditions in which their kind evolved. Our currents lab project are focus in sensory ecology, especially in the visual system, from single photoreceptor recording, electroretinogram (ERG), retina slices, multi electrodes array (254 X) patch-clamp and measure of the reflectance spectra, from animals and their microhabitat, that are likely to be used as signals in sexual selection, recognition of conspecifics, camouflage.

Furthermore, at the retinal level an intricate bioelectrical neural network respond on the behavioral relevance  of the task and mathematical tools helps to understand such behavior. In the field of Neurobiology of Learning and Memory, we are using behavior, biochemistry and synaptic plasticity (LTP, LTD) approaches in the aged rodent Octodon degus that develop brain the hallmarks  of Alzheimer diseases.




Special issue Journal of Physiology Paris. ed by MJ Escobar & AG Palacios : Neural Coding and Natural Image Statistics

KEOPS IN THE NEWS ANR-CONICYT Building strong scientific collaborations for the long term

POLICY AND COMPLEX SYSTEMS Volume 1, Issue 1, Spring 2014 (PDF)
LAS RUTAS DE LA COMPLEJIDAD, 2014, eds. E. Bustos, P. Marquet, A. Palacios



 Selected Publications (2010-):

  • Martinez J, Palacios AG, Marquez IN, Arroyo MTK, Mpdozis J (2010). Can red floweers be conspicuous to bees? Bombus dahbomii and South American temperate forests flowers as a case in point.  J Exp Biol 213: 564-571. PDF
  • Palacios AG, Bozinovic F, Vielma A, Arrese CA, David M. Hunt DM, Peichl L (2010) Retinal Photoreceptor Arrangement, SWS and LWS Opsin Sequence, and Electroretinography in the South American Marsupial elegans (Waterhouse, 1839). Journal Comparative Neurology. 518(9):1589-602. PDF
  • Schleich C, Vielma A, Glosmann M, Palacios AG, Peichl L (2010) The retinal photoreceptors of two subterranean Tuco-tuco species (Rodentia, Ctenomys): Morphology, topography and spectral sensitivity. Journal Comparative Neurology. 518(9):4001-4015.
  • Munoz P, Aspe M, Contreras LS, Palacios AG. (2010) Role od DNA methylation during recogition memory in hippocampus and perirhinal cortex in ratas. Biological Research 43(2):251-258.
  • Vielma A, Delgado LM, Elgueta C, Palacios AG, Schmachtenberg. (2010). Nitric Oxide amplifies the rod response of rat retina, measured by electroretinography. Experimental Eye Research 91(5):700-709.
  • Braidy N, Munoz P, Palacios AG, Castellano-Gonzalez G, Inestrosa NC, Chung RS, Sachdev P, Guillemin GJ. (2011). Recent animal models for Alzheimer’s diseases: Clinical implications and basic research. Journal Neural Transmission. 119(2):173-195.
  • Vasquez JC, Palacios AG, Marre O, Berry II MJ, Cessac B. (2012). Gibbs distribution analysis of temporal correlation structure on multicell spike trains from retina ganglion cells. Journal of Physiology Paris. 106(3-4):120-7.
  • Huang S, Treviño M, He K, Ardiles A, Di Pasquale R, Guo Y, Palacios AG, Huganir R and Kirkwood A. (2012) Pull-Push neuromodulation of LTP and LTD enables bidirectional experience-induced synaptic scaling in visual cortex. Neuron. 73(3):497-510.
  • Ardiles AO, Tapia-Rojas CC, Mandal M, Alexandre F, Kirkwood A, Inestrosa NC , Palacios AG. (2012) Post-synaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer’s disease. Proceeding National Academy of Science. 109 (34) 13835-13840. Featured in: Pour la ScienceAlzheimer Research Forum, Science Biologiques; New See Citation Metrics
  • Ardiles A, Ewer J, Acosta ML, Kirkwood A, Martinez A, Ebensperger  LA, Bozinovic  F,  Lee TM, Palacios AG. (2013). Octodon degus (Molina 1782): A model in comparative biology and biomedicine. Cold Spring Harbor Protocols. 4: 312-318. 
  • Palacios AG, Lee TM. (2013). Husbandry and Breeding in the Octodon degus (Molina 1782). Cold Spring Harbor Protocols. 4: 350-353.
  • Ocampo-GarcésA, Hernandez  F, Palacios AG. (2013). REM sleep phase preference in the crepuscular Octodon degus assessed by selective REM sleep deprivationSleep. 36(8):1247-1256.
  • Vega-Zuniga T, Medina FS, Fredes F, Zuniga C, Severín D, Palacios AG, Karten HJ, Mpodozis J. (2013). Does nocturnality drive binocular vision? Octodontine rodents as a case study.  PLoS ONE 8(12): e84199. doi:10.1371/journal.pone.0084199. New See Citation Metrics
  • Escobar M.J., Palacios A.G. (2013). Beyond the retina neural coding: On Models and Neural Rehabilitation. J Physiol Paris. 107(5):335-7.
  • Lowe J, Chang YL, Ardiles AO, Lim JC, Grey AC, Robertson KM, Danesh-Meyer HV,  Palacios AG, Acosta ML. (2014).  Alzheimer’s disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers. Alzheimer & Dementia. 10(2):251–261.
  • Alvaro O Ardiles, Carolina Flores-Muñoz, Gabriela Toro-Ayala, Ana María Cárdenas, Adrian G Palacios, Pablo Muñoz, Marco Fuenzalida, Juan C Saez, Agustin D Martinez. (2014). Pannexin 1 Regulates Bidirectional Hippocampal Synaptic Plasticity in Adult Mice. Front. Cell. Neurosci. | doi: 10.3389/fncel.2014.00171
  • Palacios-Munoz A, Escobar MJ, Vielma A, Araya J, Astudillo A, Garcia I, Valdivia G, Hurtado J, Schmachtenberg OMartinez ADPalacios AG (2014) Role of Connexin Channels in the Retinal Light Response of a Diurnal Rodent. Front Cell Neurosci. 2014; 8: 249.
  • Inestrosa, N. C., Ríos, J. A., Cisternas, P., Tapia-Rojas, C., Rivera, D.S., Braidy, N., Zolezzi, J. M., Godoy, J. A., Carvajal, F. J., Ardiles, A. O., Bozinovic, F., Palacios, A. G. and Sachdev, P. S. (2015), Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer’s Disease. Brain Pathology. doi:10.1111/bpa.12226
  • Alex H Vielma; Adolfo Agurto; Joaquín Valdés; Adrián G Palacios; Oliver Schmachtenberg. (2014). Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells. PLoS One, 9(12):e114330
  • Claudio Elgueta, Alex Harry Vielma, Adrian G Palacios and Oliver Schmachtenberg. (2015). Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Frontiers in Cellular Neuroscience 9(6):1-11.
  • Lucia Y Du, Lily Y-L Chang, Alvaro O Ardiles, Cheril Tapia-Rojas, Joaquin Araya, Nibaldo C Inestrosa, Adrian G Palacios* and Monica L Acosta*. (2015). Alzheimer’s disease-related protein expression in the retina of aged Octodon degus. Plos One. DOI: 10.1371/journal.pone.0135499. *equal contribution.
  • Hui Wang, Alvaro Ardiles, Sunggu Yang, Gonzalo Valdivia, Min Baek, Trinh Tran, Rafael Posada-Duque, Yang-An Chuang, Adrian G. Palacios, Michela Gallagher, Paul Worley, Alfredo Kirkwood. (2016). Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the hippocampus. The Journal of Neuroscience, 3 February 2016, 36(5):1723-1729; doi:10.1523/JNEUROSCI.0878-15.2016.
  • Claudia Salazar, Gonzalo Valdivia, Álvaro O Ardiles, John Ewer, Adrián G Palacios. (2016). Genetic variants associated with neurodegenerative Alzheimer disease in natural models. Biol Res (2016) 49:14 DOI 10.1186/s40659-016-0072-9.
  • Martínez G, Vidal RL, Mardones P, Serrano FG, Ardiles AO, Wirth C, Valdés P, Thielen P, Schneider BK, Kerr B, Valdés JL, Palacios AG, Inestrosa NC, Glimcher LH, Hetz C. (2016).  Regulation of memory formation by the transcription factor XBP1. Cell Reports: 14(6):1382 – 1394
  • Vega-Zuniga T, Medina FS, Karten HJ, Marín G, Letelier JC, Palacios AG, Nemec P, Schleich CE, Mpodozis J. (2016). Selective binocular vision loss in two subterranean caviomorph rodents: Spalacopus cyanus and Ctenomys talarum. Scientific Reports | 7:41704 | DOI: 10.1038/srep41704. 1-12.
  • Claudia Duran-Aniotz, Victor Hugo Cornejo, Sandra Espinoza, Álvaro O. Ardiles, Danilo B. Medina, Claudia Salazar, Andrew Foley, Ivana Gajardo, Peter Thielen, Takao Iwawaki, Wiep Scheper, Claudio Soto, Adrian G. Palacios, Jeroen J. M. Hoozemans, Claudio Hetz. (2017) IRE1 signaling exacerbates Alzheimer’s disease pathogenesis. “IRE1 signaling exacerbates Alzheimer’s disease pathogenesis”. Acta Neuropathol doi:10.1007/s00401-017-1694-x
  • Missing colors: an enactivist approach to perception. Adrian G. Palacios, Maria Jose Escobar, Esteban Céspedes. (2017) Special issue on Francisco Varela, “Missing the Woods for the Trees: Neglected Aspects of Francisco Varela’s Work”. Under revisión. Journal Constructivist Foundations.
  • Claudio Elgueta, Felix Leroy, Oliver Schmachtenberg, Adrian G. Palacios, 2017. Electrical coupling between A17 cells enhances reciprocal inhibitory feedback to rod bipolar cells”. Under revisión. Scientific Reports.
  • Ruben Herzog, Marıa-Jose Escobar, Adrian G. Palacios, Bruno Cessac. 2017. Dimensionality Reduction on Maximum Entropy Models on Spiking Networks. Plos Computational Biology. Submitted

Book Chapters

  • Palacios AG, Cosmelli D, Cohen-Varela A. (2011). Un recorrido junto a Francisco Varela. Pag. 11-22. Edit. Adrian Palacios y Amy Cohen-Varela. La ciencia del ser: Las rutas de Francisco Varela. Editorial Universidad de Valparaiso. 320 p.
  • Cessac B,  Palacios A. Spike train statistics from empirical facts to theory: the case of the retina, in “Modeling in Computational Biology and Biomedicine: A Multidisciplinary Endeavor”, F. CAZALS, P. KORNPROBST (editors), Lectures Notes in Mathematical and Computational Biology (LNMCB), Springer-Verlag, 2013.
  • Juan Pablo Cárdenas, Gastón Olivares, Fabiola Cabrera, Rodrigo Alfaro, Daniel Goya, Horacio Samaniego, Jorge Gibert, Adrián G. Palacios. (2014). Redes complejas: un caso de estudio sobre la colaboración científica. En Las Rutas de la Complejidad. Eds. Bustos, Marquez y Palacios. Pag. 177-210.
  • Las Rutas de la Complejidad. (2014). Editores: Edmundo Bustos Azócar, Pablo Marquet Iturriaga y Adrián Palacios Vargas. Ediciones Instituto de Sistemas Complejos de Valparaiso. ISBN 978-956-9478-00-0. 236 paginas

Outgoing Grants

Outgoing Collaborations

Computational Neuroscience: INRIA (F. AlexandreT. VievilleB. Cessac), Maria Jose Escobar , UTFSM, Chile. JM Hurtado, UV.

Alzheimer Disease (A. Kirkwood , Hopkins U, USA; N. Inestrosa PUC, Chile, M. Acosta, U Auckland)



El aporte del Romanticismo al conocimiento de la Neurociencia. Academia de Ciencia. 2012.

Adrián Palacios: La importancia de los modelos. 2012

Que sabemos de memoria y vision?. 2012.

Roedor chileno se convierte en modelo para estudiar el alzheimer y otras enfermedades. El Mercurio. 2012.


Postdoctoral & Research Fellows (2011-)

  1. 2012-2013. Jose Hurtado, Retinal Coding and Multi-electrodes recording. 
  2. 2011-2012. Alvaro Ardiles, CINV-UV

Graduate Students (2011-)

  1. 2014-2016 Ruben Herzog, Master of Science, Universidad de Chile. Tutor
  2. 2014-2016  Camilo Miguel, Master in Science mention Neuroscience UV
  3. 2013-2016  Claudia Salazar, Master in Science mention Neuroscience UV
  4. 2013- Cesar Ravello, PhD in Science mention Neuroscience. UV. Tutor
  5. 2011- 2014 Joaquin Araya, Master in Science mention Neuroscience UV. Co-Tutor
  6. 2011-2012. Aland Astudillo Master Ing Biomedica, UV. Tutor
  7. 2007-2013. Tatiana Cevo PhD in Science mention Neuroscience. UV. Tutor

Research Assistant/Undergraduated / Internships (2013-)

  1. 2016- Cristobal Ibaceta, Biochemistry
  2. 2016- David Neira, Biochemistry
  3. 2015- Felipe Olivares, Biochemistry
  4. 2015 Arnaud Ruggeri-Begeault,  France, Lyon INSA
  5. 2014-2015 Ivana Gajardo, Biochemistry
  6. 2013-2015 Gonzalo Valdivia, Biochemistry
  7. 2013- 2015 Michael Pizarro, Biology